Hypophagic and hypolocomotive effects of metachloro phenyl piperazine in rats treated with theophylline and caffeine

Pakistan Journal of Pharmaceutical Sciences

Volumn 24, Issue 3, 2011, Pages 251-254

  Alam, Nausheen ^a   Haleem, Darakshan Jabeen ^a   Najam, Rahila ^a   Haider, Syeda ^a   Ahmed, Shahida Perveen ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

Anorexia; Anxiety; Caffeine; m CPP; Theophylline

Indexed keywords

CAFFEINE; METACHLORO PHENYL PIPERAZINE; PIPERAZINE DERIVATIVE; SEROTONIN; SEROTONIN 2C RECEPTOR; THEOPHYLLINE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ANXIETY DISORDER; ARTICLE; COFFEE; CONTROLLED STUDY; HYPOPHAGIA; NONHUMAN; RAT; TEA;

ANIMALS; CAFFEINE; DRUG INTERACTIONS; EATING; MOTOR ACTIVITY; PIPERAZINES; RATS; RATS, WISTAR; SEROTONIN RECEPTOR AGONISTS; THEOPHYLLINE;

EID: 79959953568     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Barr LC, Goodman WK, Price LH, McDougle CJ and Charney DS (1992). The serotonin hypothesis of obsessive compulsive disorder: Implications of pharmacologic challenge studies. J. Clin. Psychiatry 53(suppl), 17-28.
2. Baxter GS, Kennett GA, Blaney F and Black Burn DP (1995). 5-HT-2 receptor subtyps: A family reunited? Trends Pharmacol. Science, 16: 105-110.
3. Fone KCF, Shalders K, Foxs ZD, Arthur R and Marsden CA (1996). Increase 5-H-2C receptor responsiveness occur on raring rates in social isolation. Psychoparmacology, 123: 346-352.
4. Curzon G (1990). Serotonin and appetite. Annals of the New York Academy of Sciences, 600: 521-530.
5. Fone KCF, Ausen RA, Topham IA, Kennett GA and Punhani T (1998). Effect of chronic and CPP on locomotion, hypophagia, plasma corticosterone and 5-HT-2C receptor levels in the rat. Br. J. Pharmacol., 123: 1707-1715. (Pubitemid 28182055)
6. Freo U, Holloway HW, Greig NH and Soncrant T (1992). Chronic treatment with m-CPP alters behavirol and cerebral metabolic responses to Serotonin agonists m-CPP and Quipazine but not 8-OH-2 di tetraline. Psychopharmacology, 107: 30-38.
7. Gibson EL, Dranfield AM and Curzon G (1992). Dissociation of effects of chronic diazepam treatment and withdrawal on hippocampal dialysate 5-HT and m-CPP induced anxiety in rats. Behave. Pharmacol., 7: 185-193.
8. Gleason SD and Shannon SE (1998). m-CPP endused changes in locomotor activity all mediated by 5 HT 1A as well as 5-HT-2C receptors in rats. Eur. J. Pharamacol., 341: 135-138.
9. Gasior M, Jaszyna M, Munzar P, Witkin JM, Goldberg SR (2002). Caffeine potentiates the discriminative-stimulus effects of nicotine in rats. Psychopharmacology (Berl). 162(4):385-95. (Pubitemid 35001901)
10. Hikiji K, Inoue K, Lwasaki S and Ichihara K (2004). Local perfusion of m-CPP into ventromedical hypothalamic nucleus but into lateral hypothelimic arear and frontal cortex, inhabits food intake in rats. Psychopharmacology, 174: 190-196. (Pubitemid 38916291)
11. Haleem DJ (2009). Exaggerated feedback control decreases brain serotonin concentration and elicits hyperactivity in a rat model of diet-restriction- induced anorexia nervosa. J. appet., 52: 44-50.
12. Haleem DJ and Haider S (1996). Food restriction decreases serotonin and its synthesis rate in the hypothalmus. NeuroReport, 7: 1153-1156. (Pubitemid 26227029)
13. Haleem DJ (1996). Serontonin appetite and anorexia nervosa. JCPSP, 3: 167-172.
14. Hewitt KN, Lee MD, Dourish CT and Clifton PG (2002). Serotonin 2 C receptors agonist and the behavioral Satiety sequence in mice. Pharmacol. Biochem. Behav, 71: 691-700. (Pubitemid 34219219)
15. Higly JD and Nlinnoila M (1997). Low central nervous system serotonergic activity is trait like and correlate with impulsive behavior: a non human primate model investigating genetic an environmental influences on neurotransmissions. Annals of the New York Academy of Sciences, 836: 39-56.
16. Heatherley SV, Hayward RC, Seers HE and Rogers PJ (2005). Cognitive and psychomotor performance, mood and pressor effects of caffeine after 4, 6 and 8h caffeine abstinence. Psychopharmacology (Berl). 178(4): 461-470. (Pubitemid 40486986)
17. Kennett GA and Curzon G (1998). Evidence that m-CPP may have behavioral effects mediated by central 5-HT IC receptors. Br. J. Pharmacol., 94: 137-147.
18. Kennett GA (1992). 5-HT 1 C receptor Antagonist have anxiolytic- like action in the rat social interaction model. Pscychopharmacology, 107: 379-384.
19. Kennett GA, Wood MD, Fright F, Trail B, Riley G, Holand V and Black Burn TB (1997). SB a selective and brain penetrant 5-HT-2C antagonist. Neuroppharmacology, 6: 609-620.
20. Kitichener SJ and Dourishc T (1994). An examination of the behavioral specificity of hypophagia induced by 5-HT-2 receptor agonist using postparandial satiety sequence in rats. Psychopharmacology, 113: 369-377.
21. Leibowitz SF (1986). Brain monoamines and peptides: role in the control of eating behaviors. Federals Proceeding, 45: 1396-1403.
22. Lucki I (1998). The spectrum of behaviors influenced by serotonin. Biological Psychiatry, 44: 151-162.
23. Lucki I, Ward HR and Frazera (1989). Effect of m-CPP on locomotor activity. J. Pharmacol. Exp. Ther., 249: 155-164.
24. Mann JJ (1999). Role of serotonergic system in the pathogenesis of major depression and suicide behavior. NeuopsychoPhrmacology, 21: 99S-105S.
25. Murphy DL, Lesch KP, Aulakh CS and Pigott TA (1991). Serotonin selective aryalpiperazines with neuroendocrine, behavioral, temperature and cardiovascular effects in human. Pharmacol. Rev., 43: 527-552.
26. Noreen S, Muhammad AH and Darakhshan JH (2008). Behavioral effects of m-CPP in a rat model of tardative dyskinesia. Pak. J. Pharm. Sci., 21: 262-268.
27. Samanin R, Mennini T, Ferraris A, Bendotti C and Garattini S (1979). m-CPP a central serotonin agonist causing powerful anorexia in rats. Nauyan S Chmiedeverg's Arch. Pharmacol., 308: 159-163. (Pubitemid 10172189)
28. Schuhler S, Clark A Joseph W, Patel A, Lehnen K and Ebiling FJ (2005). Involvement of 5-HT receptor in the regulation of food intake in Siberian hamsters. J. Neuroendocrinol., 17: 276-285. (Pubitemid 40711622)
29. Sills MA, Lucki I and Frazer A (1985). Development of selective tolerance to the serotonin behavioral syndrome and suppression of locomotors activity after repeated administration of m-CPP. Life Sci., 36: 2463-2469. (Pubitemid 15072752)
30. Tecott LH (2007). Serotonin and the orchestration of energy balance. Cell Metabolism, 6: 352-361.
31. Uysal UD, Aturki Z, Raggi MA and Fanali S (2009). Separation of catechins and methylxanthines in tea samples by capillary electrochromatography. J. Sep. Sci., 32(7): 1002-1010.
32. White BC, Lincoln CA, Pearce NW, Reeb R and Vaida C (1980). Anxiety and muscle tension as consequences of caffeine withdrawal. Science, 209(4464): 1547-1548. (Pubitemid 11235155)