Anti-saccade performance predicts executive function and brain structure in normal elders

Cognitive and Behavioral Neurology

Volumn 24, Issue 2, 2011, Pages 50-58

  Mirsky, Jacob B ^a   Heuer, Hilary W ^a   Jafari, Aria ^a   Kramer, Joel H ^a   Schenk, Ana K ^a   Viskontas, Indre V ^a   Miller, Bruce L ^a   Boxer, Adam L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

anti saccade; cognitive reserve; executive function; frontal lobe; normal aging

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN; BRAIN SIZE; CLINICAL ARTICLE; COGNITIVE DEFECT; EXECUTIVE FUNCTION; FEMALE; FRONTAL LOBE; GRAY MATTER; HUMAN; LINEAR REGRESSION ANALYSIS; MALE; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; STROOP TEST; TASK PERFORMANCE; VOXEL BASED MORPHOMETRY;

AGED; AGING; ATTENTION; COGNITION; EXECUTIVE FUNCTION; FEMALE; FRONTAL LOBE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; ORGAN SIZE; REACTION TIME; SACCADES;

EID: 79959952087     PISSN: 15433633     EISSN: 15370887     Source Type: Journal    
DOI: 10.1097/WNN.0b013e318223f6c6     Document Type: Article

References (59)

1. Kramer JH, Mungas D, Reed BR, et al. Longitudinal MRI and cognitive change in healthy elderly. Neuropsychology. 2007;21: 412-418. (Pubitemid 47445212)
2. Mungas D, Harvey D, Reed BR, et al. Longitudinal volumetric MRI change and rate of cognitive decline. Neurology. 2005;65:565-571. (Pubitemid 41170716)
3. Blacker D, Lee H, Muzikansky A, et al. Neuropsychological measures in normal individuals that predict subsequent cognitive decline. Arch Neurol. 2007;64:862-871. (Pubitemid 46919842)
4. Fine EM, Delis DC, Wetter SR, et al. Cognitive discrepancies versus APOE genotype as predictors of cognitive decline in normalfunctioning elderly individuals: a longitudinal study. Am J Geriatr Psychiatry. 2008;16:366-374.
5. Carlson MC, Xue QL, Zhou J, et al. Executive decline and dysfunction precedes declines in memory: the women's health and aging study II. J Gerontol A Biol Sci Med Sci. 2009;64:110-117.
6. Stern Y. Cognitive reserve. Neuropsychologia. 2009;47:2015-2028.
7. Brickman AM, Siedlecki KL, Muraskin J, et al. White matter hyperintensities and cognition: testing the reserve hypothesis. Neurobiol Aging. [Epub November 17 2009].
8. Caselli RJ, Dueck AC, Osborne D, et al. Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect. N Engl J Med. 2009;361:255-263.
9. Hallet PE. Primary and secondary saccades to goals defined by instructions. Vision Res. 1978;18:1279-1296.
10. Radant AD, Claypoole K, Wingerson DK, et al. Relationships between neuropsychological and oculomotor measures in schizophrenia patients and normal controls. Biol Psychiatry. 1997; 42:797-805. (Pubitemid 27468207)
11. Everling S, Fischer B. The antisaccade: a review of basic research and clinical studies. Neuropsychologia. 1998;36:885-899. (Pubitemid 28404316)
12. Munoz DP, Everling S. Look away: the anti-saccade task and the voluntary control of eye movement. Nat Rev Neurosci. 2004;5:218-228. (Pubitemid 38252478)
13. Boxer AL, Garbutt S, Rankin KP, et al. Medial versus lateral frontal lobe contributions to voluntary saccade control as revealed by the study of patients with frontal lobe degeneration. J Neurosci. 2006;26:6354-6363.
14. Garbutt S, Matlin A, Hellmuth J, et al. Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer's disease. Brain. 2008;131:1268-1281.
15. Rosse RB, Schwartz BL, Kim SY, et al. Correlation between antisaccade and Wisconsin card sorting test performance in schizophrenia. Am J Psychiatry. 1993;150:333-335. (Pubitemid 23046527)
16. Levy DL, Mendell NR, Holzman PS. The antisaccade task and neuropsychological tests of prefrontal cortical integrity in schizophrenia: empirical findings and interpretative considerations. World Psychiatry. 2004;3:32-40.
17. Hutton SB, Huddy V, Barnes TR, et al. The relationship between antisaccades, smooth pursuit, and executive dysfunction in firstepisode schizophrenia. Biol Psychiatry. 2004;56:553-559. (Pubitemid 39336402)
18. Zanelli J, MacCabe J, Toulopoulou T, et al. Neuropsychological correlates of eye movement abnormalities in schizophrenic patients and their unaffected relatives. Psychiatry Res. 2009;168: 193-197.
19. Gooding DC, Basso MA. The tell-tale tasks: a review of saccadic research in psychiatric patient populations. Brain Cogn. 2008;68: 371-390.
20. O'Driscoll GA, Alpert NM, Matthysse SW, et al. Functional neuroanatomy of antisaccade eye movements investigated with positron emission tomography. Proc Natl Acad Sci U S A. 1995;92: 925-929.
21. Connolly JD, Goodale MA, Menon RS, et al. Human fMRI evidence for the neural correlates of preparatory set. Nat Neurosci. 2002;5:1345-1352. (Pubitemid 35417771)
22. Curtis CE, D'Esposito M. Success and failure suppressing reflexive behavior. J Cogn Neurosci. 2003;15:409-418. (Pubitemid 36438950)
23. Pierrot-Deseilligny C, Muri RM, Ploner CJ, et al. Decisional role of the dorsolateral prefrontal cortex in ocular motor behaviour. Brain. 2003;126:1460-1473. (Pubitemid 36644389)
24. Pierrot-Deseilligny C, Muri RM, Nyffeler T, et al. The role of the human dorsolateral prefrontal cortex in ocular motor behavior. Ann N Y Acad Sci. 2005;1039:239-251. (Pubitemid 40979883)
25. Ettinger U, Ffytche DH, Kumari V, et al. Decomposing the neural correlates of antisaccade eye movements using event-related FMRI. Cereb Cortex. 2008;18:1148-1159.
26. Pierrot-Deseilligny C, Milea D, Muri RM. Eye movement control by the cerebral cortex. Curr Opin Neurol. 2004;17:17-25. (Pubitemid 38316775)
27. Leigh RJ, Zee DS. The Neurology of Eye Movements. New York: Oxford University Press; 1999.
28. Derrfuss J, Brass M, Neumann J, et al. Involvement of the inferior frontal junction in cognitive control: meta-analyses of switching and Stroop studies. Hum Brain Mapp. 2005;25:22-34. (Pubitemid 40656190)
29. Curtis CE, Calkins ME, Iacono WG. Saccadic disinhibition in schizophrenia patients and their first-degree biological relatives. A parametric study of the effects of increasing inhibitory load. Exp Brain Res. 2001;137:228-236. (Pubitemid 32250035)
30. Blekher T, Johnson SA, Marshall J, et al. Saccades in presymptomatic and early stages of Huntington disease. Neurology. 2006;67: 394-399. (Pubitemid 44214959)
31. Olincy A, Ross RG, Youngd DA, et al. Age diminishes performance on an antisaccade eye movement task. Neurobiol Aging. 1997;18: 483-489. (Pubitemid 27497144)
32. Klein C, Fischer B, Hartnegg K, et al. Optomotor and neuropsychological performance in old age. Exp Brain Res. 2000;135:141-154.
33. Peltsch A, Hemraj A, Garcia A, et al. Age-related trends in saccade characteristics among the elderly. Neurobiol Aging. Epub May 2 2009.
34. Sweeney JA, Rosano C, Berman RA, et al. Inhibitory control of attention declines more than working memory during normal aging. Neurobiol Aging. 2001;22:39-47. (Pubitemid 32332997)
35. Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43:2412-2414. (Pubitemid 23346995)
36. Agosta F, Vossel KA, Miller BL, et al. Apolipoprotein E epsilon4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia. Proc Natl Acad Sci U S A. 2009;106:2018-2022.
37. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-198.
38. Yesavage JA, Brink TL, Rolse TL, et al. Development and validity of a Geriatric depression scale: a preliminary report. J Psychiatric Res. 1983;17:37-49.
39. Kramer JH, Jurik J, Sha SJ, et al. Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and Alzheimer disease. Cogn Behav Neurol. 2003;16:211-218. (Pubitemid 37517826)
40. Delis DC, Kaplan EB, Kramer JH. The Delis-Kaplan Executive Function System. San Antonio, TX: The Psychological Corporation; 2001.
41. Wechsler D. Wechsler Adult Intelligence Scale. 3rd ed. San Antonio, TX: The Psychological Corporation; 1997.
42. Kaplan E, Goodglass H, Wintraub S. The Boston Naming Test. Philadelphia: Lea and Febiger; 1983.
43. Warrington EK, James M. The Visual Object and Space Perception Battery. Bury St Edmunds: Thames Valley Test Company; 1991.
44. Ashburner J, Andersson JL, Friston KJ. Image registration using a symmetric priorFin three dimensions. Human Brain Mapping. 2000;9:212-225. (Pubitemid 30194717)
45. Good CD, Johnsrude IS, Ashburner J, et al. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage. 2001;14:21-36. (Pubitemid 32552740)
46. Manoach DS, Thakkar KN, Cain MS, et al. Neural activity is modulated by trial history: a functional magnetic resonance imaging study of the effects of a previous antisaccade. J Neurosci. 2007;27:1791-1798. (Pubitemid 46280082)
47. Dyckman KA, Camchong J, Clementz BA, et al. An effect of context on saccade-related behavior and brain activity. Neuroimage. 2007;36:774-784. (Pubitemid 46907629)
48. Derrfuss J, Brass M, von Cramon DY, et al. Neural activations at the junction of the inferior frontal sulcus and the inferior precentral sulcus: interindividual variability, reliability, and association with sulcal morphology. Hum Brain Mapp. 2009;30:299-311.
49. Crawford TJ, Higham S, Renvoize T, et al. Inhibitory control of saccadic eye movements and cognitive impairment in Alzheimer's disease. Biol Psychiatry. 2005;57:1052-1060. (Pubitemid 40603088)
50. Benjamini Y, Hochberg Y. Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc Ser B Stat Methodol. 1995;57:289-300.
51. Ettinger U, Antonova E, Crawford TJ, et al. Structural neural correlates of prosaccade and antisaccade eye movements in healthy humans. Neuroimage. 2005;24:487-494. (Pubitemid 41359044)
52. Ettinger U, Kumari V, Chitnis XA, et al. Volumetric neural correlates of antisaccade eye movements in first-episode psychosis. Am J Psychiatry. 2004;161:1918-1921. (Pubitemid 39314691)
53. Bagary MS, Hutton SB, Symms MR, et al. Structural neural networks subserving oculomotor function in first-episode schizophrenia. Biol Psychiatry. 2004;56:620-627. (Pubitemid 39446842)
54. Roe CM, Xiong C, Miller JP, et al. Education and Alzheimer disease without dementia: support for the cognitive reserve hypothesis. Neurology. 2007;68:223-228. (Pubitemid 46105742)
55. Garibotto V, Borroni B, Kalbe E, et al. Education and occupation as proxies for reserve in aMCI converters and AD: FDG-PET evidence. Neurology. 2008;71:1342-1349.
56. Calkins ME, Dobie DJ, Cadenhead KS, et al. The consortium on the genetics of endophenotypes in schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration. Schizophr Bull. 2007;33:33-48. (Pubitemid 46026258)
57. Mintun MA, Larossa GN, Sheline YI, et al. [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology. 2006;67:446-452. (Pubitemid 44214969)
58. Pike KE, Savage G, Villemagne VL, et al. Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease. Brain. 2007;130:2837-2844. (Pubitemid 350033975)
59. Li G, Sokal I, Quinn JF, et al. CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment: a follow-up study. Neurology. 2007;69:631-639. (Pubitemid 47256004)