Ultraviolet phototoxicity to the retina

Eye and Contact Lens

Volumn 37, Issue 4, 2011, Pages 196-205

  Glickman, Randolph D ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

Light damage; Phototoxicity; Retina; Ultraviolet light

Indexed keywords

3 HYDROXYKYNURENINE; 4 HYDROXYNONENAL; ABC TRANSPORTER; ALPHA TOCOPHEROL; AMIODARONE; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; CHLOROQUINE; COPPER; DOXYCYCLINE; FLAVOPROTEIN; FREE RADICAL; GLUCOCORTICOID; HEMOPROTEIN; HYDROCHLOROTHIAZIDE; HYPERICIN; KETOPROFEN; LIPOFUSCIN; LOMEFLOXACIN; MALONALDEHYDE; MELANIN; MELANOPSIN; METHOXSALEN; PHENOTHIAZINE; PHOSPHATIDYLETHANOLAMINE; PIROXICAM; XANTHOPHYLL; ZEAXANTHIN; ZINC;

ABSORPTION; ANISOTROPY; AQUEOUS HUMOR; BLUE LIGHT; CENTRAL NERVOUS SYSTEM; CHOROID; CHROMATOPHORE; CORNEA; DENSITY; DIETARY INTAKE; DISEASE COURSE; DNA MODIFICATION; DRUG PENETRATION; DRUG UPTAKE; ELECTROMAGNETIC FIELD; ELECTROMAGNETIC RADIATION; ELECTRORETINOGRAPHY; EYE; EYE DISEASE; GENE EXPRESSION; GROUPS BY AGE; HAZARD; HISTOLOGY; HUMAN; IRRADIATION; LASER; LENS; LIGHT; LIGHT DAMAGE; LIGHT EXPOSURE; LIGHT INTENSITY; LIGHT SCATTERING; LIPID PEROXIDATION; LONG TERM EXPOSURE; METABOLIC STRESS; MITOCHONDRION; NONHUMAN; OPHTHALMOSCOPY; OXIDATIVE STRESS; PHOTODYNAMIC THERAPY; PHOTON; PHOTOOXIDATION; PHOTORECEPTOR; PHOTOTOXICITY; PIGMENT EPITHELIUM; PRIMATE; PRIORITY JOURNAL; RETINA; RETINA GANGLION CELL; RETINA INJURY; RETINA MACULA AGE RELATED DEGENERATION; RETINOPATHY; REVIEW; RODENT; SAFETY; SKIN DEFECT; THERMAL INJURY; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; ULTRAVIOLET C RADIATION; ULTRAVIOLET RADIATION; VITAMIN SUPPLEMENTATION; VITREOUS BODY; WHITE LIGHT;

ANIMALS; EYE BURNS; HUMANS; RETINA; ULTRAVIOLET RAYS;

EID: 79959931383     PISSN: 15422321     EISSN: 1542233X     Source Type: Journal    
DOI: 10.1097/ICL.0b013e31821e45a9     Document Type: Review

References (105)

1. Plato. Phaedo. In: Jowett B, translator. The Dialogues of Plato. New York,NY, Charles Scribner & Sons, 1911.
2. Mooney J. Myths of the Cherokee. 19th Annual Report of the Bureau of American Ethnology for the Year 1897-1898, Part I. Mineola, NY: Dover Publications, 1996, pp 295-300.
3. Newton I. The Correspondence of Isaac Newton, Vol III, 1961 ed. Cambridge, United Kingdom, For the Royal Society by the Cambridge University Press, 1688, pp 153-154.
4. Boettner EA, Wolter JR. Transmission of the ocular media. Invest Ophthalmol [now Invest Ophthalmol Vis Sci] 1962;1:776-783.
5. Dillon J, Zheng L, Merriam JC, et al. Transmission spectra of light to the mammalian retina. Photochem Photobiol 2000;71:225-229.
6. Gaillard ER, Zheng L, Merriam JC, et al. Age-related changes in the absorption characteristics of the primate lens. Invest Ophthalmol Vis Sci 2000;41:1454-1459. (Pubitemid 30261869)
7. White TJ, Mainster MA, Wilson PW, et al. Chorioretinal temperature increases from solar observation. Bull Math Biophys 1971;33:1-17.
8. Barth J, Cadet J, Césarini JP, et al.134/1 TC 6-26 Report: Standardization of the terms UV-A1, UV-A2, and UV-B. In: CIE 134-1999 Collection in Photobiology and Photochemistry. Vienna, Austria, Commission Internationale de l'Eclairage, 1999.
9. Sliney DH, Trokel SL. Medical Lasers and Their Safe Use. New York, NY, Springer-Verlag, 1992, pp 39.
10. Brainard GC, Beacham S, Sanford BE, et al. Near ultraviolet radiation elicits visual evoked potentials in children. Clin Neurophysiol 1999;110: 379-383. (Pubitemid 29207485)
11. Sliney DH. How light reaches the eye and its components. Int J Toxicol 2002;21:501-509. (Pubitemid 36090839)
12. Mainster MA, Turner PL. Ultraviolet-B phototoxicity and hypothetical photomelanomagenesis: Intraocular and crystalline lens photoprotection. Am J Ophthalmol 2010;149:543-549.
13. Hillenkamp F. Laser radiation tissue interaction. Health Phys 1989;56:613-616.
14. Jacques SL. Laser-tissue interactions. In: Hardy K, Meltz M, Glickman R, eds. Non-Ionizing Radiation: An Overview of the Physics and Biology. Madison, WI, Medical Physics Publishing, 1997, pp 81-98.
15. Jacques SL. Laser-tissue interactions. Photochemical, photothermal, and photomechanical. Surg Clin North Am 1992;72:531-558.
16. Glickman RD. Phototoxicity to the retina: Mechanisms of damage. Int J Toxicol 2002;21:473-490. (Pubitemid 36090837)
17. Hecht E. Optics, 4th ed. Reading, MA, Addison Wesley, 2002, pp 86-95.
18. Istock TH. Solar retinopathy: A review of the literature and case report. J Am Optom Assoc 1985;56:374-382.
19. Ham WT Jr, Mueller HA, Ruffolo JJ Jr, et al. Sensitivity of the retina to radiation damage as a function of wavelength. Photochem Photobiol 1979; 29:735-743.
20. Ham WT Jr, Mueller HA, Ruffolo JJ Jr, et al. Action spectrum for retinal injury from near-ultraviolet radiation in the aphakic monkey. Am J Ophthalmol 1982;93:299-306. (Pubitemid 12192849)
21. Ham WT Jr, Ruffolo JJ Jr, Mueller HA, et al. Histologic analysis of photochemical lesions produced in rhesus retina by short-wavelength light. Invest Ophthalmol Vis Sci 1978;17:1029-1035. (Pubitemid 8397576)
22. HamWT Jr, Mueller HA, Ruffolo JJ Jr, et al. Solar retinopathy as a function of wavelength: Its significance for protective eyewear. In: Williams TP, ed. The Effects of Constant Light on Visual Processes. New York, NY, Plenum Press, 1980, pp 319-346.
23. Noell WK, Walker VS, Kang BS, et al. Retinal damage by light in rats. Invest Ophthalmol Vis Sci 1966;5:450-473.
24. Rapp LM, Williams TP. A parametric study of retinal light damage in albino and pigmented rats. In: Williams TP, ed. The Effects of Constant Light on Visual Processes. New York, NY, Plenum Press, 1980, pp 135-159.
25. Ginsberg HM, LaVail MM. Light-induced retinal degeneration in the mouse: Analysis of pigmentation mutants. In: LaVail MM, ed. Retinal Degeneration: Experimental and Clinical Studies. New York, NY, Alan R. Liss, 1985, pp 449-469.
26. van Norren D. Photochemical damage to the eye. News Physiol Sci 1991;6: 232-234.
27. Rapp LM, Smith SC. Evidence against melanin as the mediator of retinal phototoxicity by short-wavelength light. Exp Eye Res 1992;54:55-62.
28. Magnavita N. Photoretinitis: An underestimated occupational injury? Occup Med (Oxf) 2002;52:223-225.
29. Solley WA, Sternberg P Jr. Retinal phototoxicity. Int Ophthalmol Clin 1999;39:1-12. (Pubitemid 29222653)
30. Verma L, Venkatesh P, Tewari HK. Phototoxic retinopathy. Ophthalmol Clin North Am 2001;14:601-609. (Pubitemid 34037676)
31. Williams TP, Howell WL. Action spectrum of retinal light-damage in albino rats. Invest Ophthalmol Vis Sci 1983;24:285-287. (Pubitemid 13108835)
32. Ham WT Jr, Mueller HA, Sliney DH. Retinal sensitivity to damage from short wavelength light. Nature 1976;260:153-155.
33. Moon ME, Clarke AM, Ruffolo JJ Jr, et al. Visual performance in the rhesus monkey after exposure to blue light. Vision Res 1978;18:1573-1577. (Pubitemid 9025507)
34. Mainster MA. Violet and blue light blocking intraocular lenses: Photoprotection versus photoreception. Br J Ophthalmol 2006;90:784-792. (Pubitemid 43835502)
35. Kremers JJM, van Norren D. Two classes of photochemical damage to the retina. Lasers Light Ophthalmol 1988;2:41-52. (Pubitemid 19036529)
36. Eldred GE, Lasky MR. Retinal age pigments generated by self-assembling lysosomotropic detergents. Nature 1993;361:724-726. (Pubitemid 23070479)
37. Harper WS, Gaillard ER. Studies of all-trans-retinal as a photooxidizing agent. Photochem Photobiol 2001;73:71-76.
38. Molday RS, Beharry S, Ahn J, et al. Binding of N-retinylidene-PE to ABCA4 and a model for its transport across membranes. Adv Exp Med Biol 2006;572:465-470. (Pubitemid 44249806)
39. Sun H, Nathans J. ABCR, the ATP-binding cassette transporter responsible for Stargardt macular dystrophy, is an efficient target of all-trans- retinalmediated photooxidative damage in vitro. Implications for retinal disease. J Biol Chem 2001;276:11766-11774.
40. Rozanowska M, Sarna T. Light-induced damage to the retina: Role of rhodopsin chromophore revisited. Photochem Photobiol 2005;81:1305-1330. (Pubitemid 43035839)
41. Boulton M, McKechnie NM, Breda J, et al. The formation of autofluorescent granules in cultured human RPE. InvestOphthalmol Visual Sci 1989;30:82-89. (Pubitemid 19039883)
42. Feeney L. Lipofuscin and melanin of human retinal pigment epithelium. Fluorescence, enzyme, cytochemical, and ultrastructural studies. Invest Ophthalmol Vis Sci 1978;17:583-600. (Pubitemid 8364254)
43. Feeney-Burns L, Eldred GE. The fate of the phagosome: Conversion to-age pigment- and impact in human retinal pigment epithelium. Trans Ophthalmol Soc UK 1983;103:416-421. (Pubitemid 14099759)
44. Marshall J. The aging retina: Physiology or pathology. Eye 1987;1:282-295.
45. Kennedy CJ, Rakoczy PE, Constable IJ. Lipofuscin of the retinal pigment epithelium: A review. Eye 1995;9:763-771. (Pubitemid 26018204)
46. Sparrow JR, Nakanishi K, Parish CA. The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci 2000;41:1981-1989. (Pubitemid 30354376)
47. Cubeddu R, Taroni P, Hu DN, et al. Photophysical studies of A2-E, putative precursor of lipofuscin, in human retinal pigment epithelial cells. Photochem Photobiol 1999;70:172-175. (Pubitemid 129549206)
48. Davies S, Elliott MH, Floor E, et al. Photocytotoxicity of lipofuscin in human retinal pigment epithelial cells. Free Radic Biol Med 2001;31:256-265. (Pubitemid 32607593)
49. Pawlak A, Wrona M, Rozanowska M, et al. Comparison of the aerobic photoreactivity of A2E with its precursor retinal. Photochem Photobiol 2003;77:253-258.
50. Roberts JE, Kukielczak BM, Hu DN, et al. The role of A2E in prevention or enhancement of light damage in human retinal pigment epithelial cells. Photochem Photobiol 2002;75:184-190.
51. Gaillard ER, Atherton SJ, Eldred G, et al. Photophysical studies on human retinal lipofuscin. Photochem Photobiol 1995;61:448-453.
52. Boulton M, Dontsov A, Jarvis-Evans J, et al. Lipofuscin is a photoinducible free radical generator. J Photochem Photobiol B Biol 1993;19:201-204. (Pubitemid 23274997)
53. Wihlmark U, Wrigstad A, Roberg K, et al. Lipofuscin accumulation in cultured retinal pigment epithelial cells causes enhanced sensitivity to blue light irradiation. Free Radic Biol Med 1997;22:1229-1234. (Pubitemid 27171965)
54. De Laey JJ, Verougstraete C. Hyperlipofuscinosis and subretinal fibrosis in Stargardt's disease. Retina 1995;15:399-406.
55. Delori FC, Staurenghi G, Arend O, et al. In vivo measurement of lipofuscin in Stargardt's disease-Fundus flavimaculatus. Invest Ophthalmol Vis Sci 1995;36:2327-2331.
56. Hayasaka S. Aging changes in lipofuscin, lysosomes and melanin in the macular area of human retina and choroid. Jpn J Ophthalmol 1989;33:36-42. (Pubitemid 19110761)
57. Solbach U, Keilhauer C, Knabben H, et al. Imaging of retinal autofluorescence in patients with age-related macular degeneration. Retina 1997;17:385-389. (Pubitemid 28076367)
58. Dontsov AE, Glickman RD, Ostrovsky MA. Retinal pigment epithelium pigment granules stimulate the photo-oxidation of unsaturated fatty acids. Free Radic Biol Med 1999;26:1436-1446. (Pubitemid 29302275)
59. Glickman RD. The origin of photo-oxidative stress in the aging eye. Prog Brain Res 2001;131:699-712.
60. Hanna N, Peri KG, Abran D, et al. Light induces peroxidation in retina by activating prostaglandin G/H synthase. Free Radic Biol Med 1997;23: 885-897. (Pubitemid 27402614)
61. Kayatz P, Heimann K, Schraermeyer U. Ultrastructural localization of lightinduced lipid peroxides in the rat retina. Invest Ophthalmol Vis Sci 1999;40: 2314-2321. (Pubitemid 29418387)
62. Naash MI, Al-Ubaidi MR, Anderson RE. Light exposure induces ubiquitin conjugation and degradation activities in the rat retina. Invest Ophthalmol Vis Sci 1997;38:2344-2354. (Pubitemid 27446952)
63. Schwartz LH, Ferrand R, Boelle PY, et al. Lack of correlation between the location of choroidal melanoma and ultraviolet-radiation dose distribution. Radiat Res 1997;147:451-456. (Pubitemid 27150376)
64. Sacca SC, Bolognesi C, Battistella A, et al. Gene-environment interactions in ocular diseases. Mutat Res 2009;667:98-117.
65. Allen JE. Drug-induced photosensitivity. Clin Pharm 1993;12:580-587. (Pubitemid 23213473)
66. Miranda MA. Assessment of the phototoxicity risk of new drugs. Arch Toxicol Suppl 1997;19:249-258.
67. Lerman S, Van Voorhees A. Cutaneous and ocular ramifications of ultraviolet radiation. In: Grant-Kels JM, ed. Dermatologic Clinics. Philadelphia, PA, W.B. Saunders, 1992, pp 483-504.
68. Roberts JE. Ocular phototoxicity. In: Marzuli FN. Dermatotoxicology. Washington, DC, Taylor and Francis, 1996, pp 307-313.
69. Mantyjarvi M, Tuppurainen K, Ikaheimo K. Ocular side effects of amiodarone. Surv Ophthalmol 1998;42:360-366. (Pubitemid 28092776)
70. GrantWM. Toxicology of the Eye. Springfield, IL, Charles C. Thomas, 1986
71. Costagliola C, Menzione M, Chiosi F, et al. Retinal phototoxicity induced by hydrochlorothiazide after exposure to a UV tanning device. Photochem Photobiol 2008;84:1294-1297.
72. Schey KL, Patat S, Chignell CF, et al. Photooxidation of lens alphacrystallin by hypericin (active ingredient in St. John's wort).Photochem Photobiol 2000;72:200-203.
73. Bagheri H, Lhiaubet V, Montastruc JL, et al. Photosensitivity to ketoprofen: Mechanisms and pharmacoepidemiological data. Drug Saf 2000;22: 339-349. (Pubitemid 30261078)
74. Martinez LJ, Sik RH, Chignell CF. Fluoroquinolone antimicrobials: Singlet oxygen, superoxide and phototoxicity. Photochem Photobiol 1998; 67:399-403. (Pubitemid 128472692)
75. Scheife RT, Cramer WR, Decker EL. Photosensitizing potential of ofloxacin. Int J Dermatol 1993;32:413-416. (Pubitemid 23189886)
76. Bailes HJ, Lucas RJ. Melanopsin and inner retinal photoreception. Cell Mol Life Sci 2010;67:99-111.
77. Patel AS, Dacey DM. Relative effectiveness of a blue light-filtering intraocular lens for photoentrainment of the circadian rhythm. J Cataract Refract Surg 2009;35:529-539.
78. Thapan K, Arendt J, Skene DJ. An action spectrum for melatonin suppression: Evidence for a novel non-rod, non-cone photoreceptor system in humans. J Physiol 2001;535:261-267. (Pubitemid 32782742)
79. Herljevic M, Middleton B, Thapan K, et al. Light-induced melatonin suppression: Age-related reduction in response to short wavelength light. Exp Gerontol 2005;40:237-242. (Pubitemid 40343015)
80. Roberts JE. Light and immunomodulation. Ann N Y Acad Sci 2000;917: 435-445.
81. Li ZY, Tso MOM, Wang HM, et al. Amelioration of photic injury in rat retina by ascorbic acid: A histopathologic study. Invest Ophthalmol Vis Sci 1985;26:1589-1598. (Pubitemid 16248704)
82. Organisciak DT, Jiang YL, Yang HM, et al. The protective effect of ascorbic acid in retinal light damage of rats exposed to intermittent light. Invest Ophthalmol Vis Sci 1990;31:1195-1202. (Pubitemid 20212344)
83. Stoyanovsky DA, Goldman R, Darrow RM, et al. Endogenous ascorbate regenerates vitamin E in the retina directly and in combination with exogenous dihydrolipoic acid. Curr Eye Res 1995;14:181-189.
84. Organisciak DT, Darrow RA, Barsalou L, et al. Light-induced damage in the retina: Differential effects of dimethylthiourea on photoreceptor survival, apoptosis and DNA oxidation. Photochem Photobiol 1999;70: 261-268. (Pubitemid 129549218)
85. Remé CE, Braschler UF, Roberts J, et al. Light damage in the rat retina: Effect of a radioprotective agent (WR-77913) on acute rod outer segment disk disruptions. Photochem Photobiol 1991;54:137-142.
86. Wenzel A, Grimm C, Seeliger MW, et al. Prevention of photoreceptor apoptosis by activation of the glucocorticoid receptor. Invest Ophthalmol Vis Sci 2001;42:1653-1659. (Pubitemid 32520761)
87. Li J, Edward DP, Lam TT, et al. Amelioration of retinal photic injury by a combination of flunarizine and dimethylthiourea. Exp Eye Res 1993;56: 71-78. (Pubitemid 23042777)
88. Busch EM, Gorgels TG, Roberts JE, et al. The effects of two stereoisomers of N-acetylcysteine on photochemical damage by UVA and blue light in rat retina. Photochem Photobiol 1999;70:353-358. (Pubitemid 129555885)
89. Tokuda K, Zorumski CF, Izumi Y. Effects of ascorbic acid on UV lightmediated photoreceptor damage in isolated rat retina. Exp Eye Res 2007;84: 537-543. (Pubitemid 46204695)
90. Wu J, Chen E, Söderberg PG. Failure of ascorbate to protect against broadband blue light-induced retinal damage in rat. Graefes Arch Clin Exp Ophthalmol 1999;237:855-860. (Pubitemid 29438468)
91. Taylor HR, Munos B, West S, et al. Visible light and risk of age-related macular degeneration. Trans Am Ophthalmol Soc 1990;88:163-178.
92. Tomany SC, Cruickshanks KJ, Klein R, et al. Sunlight and the 10-year incidence of age-related maculopathy: The Beaver Dam eye study. Arch Ophthalmol 2004;122:750-757. (Pubitemid 38596256)
93. Sackett CS, Schenning S. The age-related eye disease study: The results of the clinical trial. Insight 2002;27:5-7.
94. Wrona M, Rozanowska M, Sarna T. Zeaxanthin in combination with ascorbic acid or alpha-tocopherol protects ARPE-19 cells against photosensitized peroxidation of lipids. Free Radic Biol Med 2004;36:1094-1101. (Pubitemid 38479863)
95. Belda JI, Romá J, Vilela C, et al. Serum vitamin E levels negatively correlate with severity of age-related macular degeneration. Mech Ageing Dev 1999;107:159-164. (Pubitemid 29138852)
96. Alves-Rodrigues A, Shao A. The science behind lutein. Toxicol Lett 2004; 150:57-83. (Pubitemid 38447237)
97. Khachik F, Bernstein PS, Garland DL. Identification of lutein and zeaxanthin oxidation products in human and monkey retinas. Invest Ophthalmol Vis Sci 1997;38:1802-1811. (Pubitemid 27382346)
98. Prasain JK, Moore R, Hurst JS, et al. Electrospray tandem mass spectrometric analysis of zeaxanthin and its oxidation products. J Mass Spectrom 2005;40:916-923. (Pubitemid 41098078)
99. Siems WG, Sommerburg O, van Kuijk FJ. Lycopene and beta-carotene decompose more rapidly than lutein and zeaxanthin upon exposure to various pro-oxidants in vitro. Biofactors 1999;10:105-113. (Pubitemid 29533817)
100. Kim WT, Suh ES. Retinal protective effects of resveratrol via modulation of nitric oxide synthase on oxygen-induced retinopathy. Korean J Ophthalmol 2010;24:108-118.
101. King RE, Kent KD, Bomser JA. Resveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibition. Chem Biol Interact 2005;151:143-149. (Pubitemid 40208564)
102. Kubota S, Kurihara T, Mochimaru H, et al. Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-kappaB activation. Invest Ophthalmol Vis Sci 2009;50:3512-3519.
103. Liu Q, Ju WK, Crowston JG, et al. Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage. Invest Ophthalmol Vis Sci 2007;48:4580-4589. (Pubitemid 351260975)
104. Amici A, Levine RL, Tsai L, et al. Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. J Biol Chem 1989;264: 3341-3346. (Pubitemid 19063388)
105. Stadtman ER. Protein oxidation and aging. Free Radic Res 2006;40: 1250-1258. (Pubitemid 44698274)