Complications with recombinant human bone morphogenetic protein-2 in posterolateral spine fusion associated with a dural tear

Spine Journal

Volumn 11, Issue 6, 2011, Pages 522-526

  Glassman, Steven D ^a,b   Gum, Jeffrey L ^b   Crawford III, Charles H ^a,b   Shields, Christopher B ^c   Carreon, Leah Y ^a  

^a NORTON LEATHERMAN SPINE CENTER   (United States)

^b University of Louisville School of Medicine   (United States)

^c Norton Neuroscience Institute   (United States)

Author keywords

Bone morphogenetic protein; Clinical outcomes; Complications; Dural tear

Indexed keywords

COLLAGEN SPONGE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ADULT; ARTICLE; BACKACHE; BRAIN FUNCTION; CASE CONTROL STUDY; COHORT ANALYSIS; CONVALESCENCE; DECOMPRESSION SURGERY; DURA MATER TEAR; FEMALE; HUMAN; LEG PAIN; MAJOR CLINICAL STUDY; MALE; MENTAL COMPOSITE SUMMARY SCORE; NEUROLOGICAL COMPLICATION; OSWESTRY DISABILITY INDEX; PEROPERATIVE COMPLICATION; PHYSICAL COMPOSITE SUMMARY SCORE; POSTEROLATERAL LUMBAR SPINE FUSION; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROPENSITY SCORE; QUALITY OF LIFE; RADICULOPATHY; SCORING SYSTEM; SHORT FORM 36; SMOKING; SPINAL CORD INJURY; SPINE FUSION; TREATMENT OUTCOME;

BONE MORPHOGENETIC PROTEIN 2; CASE-CONTROL STUDIES; DURA MATER; FEMALE; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; RECOMBINANT PROTEINS; RECOVERY OF FUNCTION; RETROSPECTIVE STUDIES; SPINAL FUSION; TRANSFORMING GROWTH FACTOR BETA;

EID: 79959925752     PISSN: 15299430     EISSN: 18781632     Source Type: Journal    
DOI: 10.1016/j.spinee.2010.05.016     Document Type: Article

References (24)

1. R.W. Haid Jr., C.L. Branch Jr., J.T. Alexander, and J.K. Burkus Posterior lumbar interbody fusion using recombinant human bone morphogenetic protein type 2 with cylindrical interbody cages Spine J 4 2004 527 538 (Pubitemid 40029169)
2. V. Joseph, and Y.R. Rampersaud Heterotopic bone formation with the use of rhBMP-2 in posterior minimal access interbody fusion Spine 32 2007 2885 2890 (Pubitemid 351339361)
3. A.T. Villavicencio, S. Burneikiene, and E.L. Nelson Safety of transforaminal lumbar interbody fusion and intervertebral recombinant human bone morphogenetic protein-2 J Neurosurg Spine 3 2005 436 443
4. D.A. Wong, A. Kumar, and S. Jatana Neurologic impairment from ectopic bone in the lumbar canal: a potential complication of off-label PLIF/TLIF use of bone morphogenetic protein-2 (BMP-2) Spine J 8 2008 1011 1018
5. K.U. Lewandrowski, C. Nanson, and R. Calderon Vertebral osteolysis after posterior interbody lumbar fusion with recombinant human bone morphogenetic protein 2: a report of five cases Spine J 7 2007 609 614 (Pubitemid 47471438)
6. J.W. McClellan, D.S. Mulconrey, R.J. Forbes, and N. Fullmer Vertebral bone resorption after transforaminal lumbar interbody fusion with bone morphogenetic protein (rhBMP-2) J Spinal Disord Tech 19 2006 483 486 (Pubitemid 44526745)
7. L.B. Shields, G.H. Raque, and S.D. Glassman Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion Spine 31 2006 542 547
8. J.D. Smucker, J.M. Rhee, and K. Singh Increased swelling complications associated with off-label usage of rhBMP-2 in the anterior cervical spine Spine 31 2006 2813 2819 (Pubitemid 44772783)
9. R.A. Meyer Jr., H.E. Gruber, and B.A. Howard Safety of recombinant human bone morphogenetic protein-2 after spinal laminectomy in the dog Spine 24 1999 747 754 (Pubitemid 29181526)
10. M. Kawakami, H. Hashizume, and T. Matsumoto Safety of epidural administration of Osteogenic Protein-1 (OP-1/BMP-7): behavioral and macroscopic observation Spine 32 2007 1388 1393 (Pubitemid 46869904)
11. C.G. Paramore, C. Lauryssen, and M.J. Rauzzino The safety of OP-1 for lumbar fusion with decompression - a canine study Neurosurgery 44 1999 1151 1155
12. A.R. Poynton, and J.M. Lane Safety profile for the clinical use of bone morphogenetic proteins in the spine Spine 27 16 Suppl 1 2002 S40 S48
13. A.E. Dmitriev, S. Farhang, and R.A. Lehman Jr. Bone morphogenetic protein-2 used in spinal fusion with spinal cord injury penetrates intrathecally and elicits a functional signaling cascade Spine J 10 2010 16 25
14. S.D. Glassman, L. Carreon, and J.R. Dimar Outcome of lumbar arthrodesis in patients sixty-five years of age or older. Surgical technique J Bone Joint Surg Am 92 Suppl 1 Pt 1 2010 77 84
15. S.D. Glassman, L.Y. Carreon, and M. Djurasovic Posterolateral lumbar spine fusion with infuse bone graft Spine J 7 2007 44 49 (Pubitemid 46002546)
16. E. Dawson, H.W. Bae, and J.K. Burkus Recombinant human bone morphogenetic protein-2 on an absorbable collagen sponge with an osteoconductive bulking agent in posterolateral arthrodesis with instrumentation. A prospective randomized trial J Bone Joint Surg Am 91 2009 1604 1613
17. J. Fairbank Revised Oswestry Disability questionnaire Spine 25 2000 2552
18. J.E. Ware, M. Kosinski, and S.K. Keller SF-36 physical and mental health summaries scales: a user's manual 1994 The Health Institute Boston, MA
19. M.P. Jensen, J.A. Turner, and J.M. Romano Correlates of improvement in multidisciplinary treatment of chronic pain J Consult Clin Psychol 62 1994 172 179 (Pubitemid 24058710)
20. R.B. D'Agostino Jr. Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group Stat Med 17 1998 2265 2281 (Pubitemid 28466823)
21. J.R. Dimar 2nd, S.D. Glassman, and J.K. Burkus Clinical and radiographic analysis of an optimized rhBMP-2 formulation as an autograft replacement in posterolateral lumbar spine arthrodesis J Bone Joint Surg Am 91 2009 1377 1386
22. Glassman SD, Howard JM, Dimar JR, et al. Complications with rhBMP. Spine, In press.
23. V.V. Patel, L. Zhao, and P. Wong An in vitro and in vivo analysis of fibrin glue use to control bone morphogenetic protein diffusion and bone morphogenetic protein-stimulated bone growth Spine J 6 2006 397 403 (Pubitemid 43964531)
24. J.A. Rihn, C. Gates, and S.D. Glassman The use of bone morphogenetic protein in lumbar spine surgery Instr Course Lect 58 2009 677 688