Safety of epidural administration of osteogenic protein-1 (OP-1/BMP-7): Behavioral and macroscopic observation

Spine

Volumn 32, Issue 13, 2007, Pages 1388-1393

  Kawakami, Mamoru ^a   Hashizume, Hiroshi ^a   Matsumoto, Takuji ^a   Enyo, Yoshio ^a   Okada, Motohiro ^a   Yoshida, Munehito ^a   Chubinskaya, Susan ^b  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bone morphogenetic protein 7; Epidural administration; Hyperalgesia; Nucleus pulposus; Osteogenic protein 1

Indexed keywords

GELATIN; LACTOSE; OSTEOGENIC PROTEIN 1;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG SAFETY; HYPERALGESIA; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISK HERNIA; MALE; MECHANICAL STIMULATION; MOTOR PERFORMANCE; NERVE ROOT; NOCICEPTIVE STIMULATION; NONHUMAN; NUCLEUS PULPOSUS; OSSIFICATION; PARESIS; PRIORITY JOURNAL; RAT; RAT STRAIN; SPRAGUE DAWLEY RAT;

ANIMALS; BONE MORPHOGENETIC PROTEINS; DISEASE MODELS, ANIMAL; HYPERALGESIA; INJECTIONS, EPIDURAL; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DISPLACEMENT; LUMBAR VERTEBRAE; MALE; MOTOR ACTIVITY; OSSIFICATION, HETEROTOPIC; PAIN THRESHOLD; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; SPINAL NERVE ROOTS; TAIL; TRANSFORMING GROWTH FACTOR BETA;

EID: 34249893926     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e318060a6b0     Document Type: Article

References (39)

1. Buckwalter JA, Martin J. Intervertebral disk degeneration and back pain. In: Weinstein JN, Gordon SL, eds. Low Back Pain: A Scientific and Clinical Overview. Rosemont, IL, American Academy of Orthopaedic Surgeons; 1996:607-23.
2. Urban JP, McMullin JF. Swelling pressure of the lumbar intervertebral discs: influence of age, spinal level, composition, and degeneration. Spine 1988;13:179-87.
3. An HS, Thonar EJ, Masuda K. Biological repair of intervertebral disc. Spine 2003;28(suppl 15):86-92.
4. Lotz JC, Kim AJ. Disc regeneration: why, when, and how. Neurosurg Clin North Am 2005;16:657-63.
5. Iatridis JC, Mente PL, Stokes IA, et al. Compression-induced changes in intervertebral disc properties in a rat tail model. Spine 1999;24:996-1002.
6. Mente PL, Stokes IA, Spence H, et al. Progression of vertebral wedging in an asymmetrically loaded rat tail model. Spine 1997;22:1292-6.
7. Kawakami M, Weinstein JN, Spratt KF, et al. Experimental lumbar radiculopathy: immunohistochemical and quantitative demonstrations of pain induced by lumbar nerve root irritation of the rat. Spine 1994;19:1780-94.
8. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988;33:87-107.
9. Kawakami M, Tamaki T, Hayashi N, et al. Possible mechanism of painful radiculopathy in lumbar disc herniation. Clin Orthop 1998;351:241-51.
10. Kawakami M, Matsumoto T, Kuribayashi K, et al. mRNA expression of interleukins, phospholipase A2, and nitric oxide synthase in the nerve root and dorsal root ganglion induced by autologous nucleus pulposus in the rat. J Orthop Res 1999;17:941-6.
11. Kawakami M, Hashizume H, Nishi H, et al. Comparison of neuropathic pain induced by the application of normal and mechanically compressed nucleus pulposus to lumbar nerve roots in the rat. J Orthop Res 2003;21:535-9.
12. Gruber HE, Fisher EC Jr, Desai B, et al. Human intervertebral disc cells from the annulus: three-dimensional culture in agarose or alginate and responsiveness to TGF-beta1. Exp Cell Res 1997;235:13-21.
13. Masuda K, Takegami K, An H, et al. Recombinant osteogenic protein-1 upregulates extracellular matrix metabolism by rabbit annulus fibrosus and nucleus pulposus cells cultured in alginate beads. J Orthop Res 2003;21:922-30.
14. Takegami K, Masuda K, An H, et al. In vivo administration of Osteogenic protein-1 increases proteoglycan content and disc height in rabbit intervertebral disc. Orthop Res Soc Trans 2000;25:338.
15. Takegami K, An HS, Kumano F, et al. Osteogenic potein-1 is most effective in stimulating nucleus pulposus and annulus fibrosus cells to repair their matrix after chondroitinase ABC-induced in vitro chemonucleolysis. Spine J 2005;5:231-8.
16. Kawakami M, Matsumoto T, Hashizume H, et al. Osteogenic protein-1 (OP-1/BMP-7) inhibits degeneration and pain-related behavior induced by chronically compressed nucleus pulposus in the rat. Spine 2005;30:1933-9.
17. Kawakami M, Matsumoto T, Hashizume H, et al. Biological manipulation for degenerative disc disease utilizing intradiscal Osteogenic Protein-1 (OP-1/BMP-7) injection: an animal study. In: Innovations in Spinal Reconstruction: Clinical Examples of Basic Science, Biomechanics, and Engineering. Lewandrowski KU, Yaszemski M. J., Kalfas I. H., Park P., McLain R. F., and Trantolo D. J., eds. Informa Healthcare, NY, pp 179-189, 2007.
18. Masuda K, Imai Y, Okuma M, et al. Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model. Spine 2006;31:742-54.
19. Chatani K, Kawakami M, Weinstein JN, et al. Characterization of thermal hyperalgesia, c-fos expression, and alterations in neuropeptides after mechanical irritation of the dorsal root ganglion. Spine 1995;20:277-90.
20. Franson RC, Saal JS, Saal JF. Human phospholipase A2 is inflammatory. Spine 1992;17(suppl):129-32.
21. Kang JD, Stefanovic-Racic M, McIntyre LA, et al. Toward a biochemical understanding of human intervertebral disc degeneration and herniation: contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases. Spine 1997;22:1065-73.
22. Saal JS, Franson RC, Dobrow R, et al. High levels of inflammatory phospholipase A2 activity in lumbar disc herniations. Spine 1990;15:674-8.
23. Miyamoto H, Saura R, Harada T, et al. The role of cyclooxygenase-2 and inflammatory cytokines in pain induction of herniated lumbar intervertebral disc. Kobe J Med Sci 2000;46:13-28.
24. Takahashi H, Suguro T, Okajima Y, et al. Inflammatory cytokines in the herniated disc of the lumbar spine. Spine 1996;21:218-24.
25. Igarashi T, Kikuchi S, Shubayev V, et al. Exogenous tumor necrosis factoralpha mimics nucleus pulposus-induced neuropathology: molecular, histologic, and behavioral comparisons in rats. Spine 2000;25:2975-80.
26. Olmarker K, Rydevik B. Selective inhibition of tumor necrosis factor-alpha prevents nucleus pulposus-induced thrombus formation, intraneural edema, and reduction of nerve conduction velocity: possible implications for future pharmacologic treatment strategies of sciatica. Spine 2001;26:863-9.
27. Olmarker K, Larsson K. Tumor necrosis factor alpha and nucleus-pulposusinduced nerve root injury. Spine 1998;23:2538-44.
28. Goupille P, Jayson MI, Valat JP, et al. The role of inflammation in disk herniation-associated radiculopathy. Semin Arthritis Rheum 1998;28:60-71.
29. Kawakami M, Tamaki T, Matsumoto T, et al. Role of leukocytes in radicular pain secondary to herniated nucleus pulposus. Clin Orthop 2000;376:268-77.
30. Kawakami M, Tamaki T, Hayashi N, et al. Mechanical compression of the lumbar nerve root alters pain-related behaviors induced by the nucleus pulposus in the rat. J Orthop Res 2000;18:257-64.
31. Hashizume H, Kawakami M, Matsumoto T, et al. A mechanism of the neurogenic pain induced by a degenerative nucleus pulposus associated with a pH change [in Japanese]. J Jpn Orthop Assoc 2003;77(suppl):1070.
32. Maves TJ, Gebhart GF, Meller ST. Continuous infusion of acidified saline around the rat sciatic nerve produces thermal hyperalgesia. Neurosci Lett 1995;194:45-8.
33. Nachemson A. Intradiscal measurements of pH in patients with lumbar rhizopathies. Acta Orthop Scand 1969;40:23-42.
34. Chubinskaya S, Kuettner KE. Regulation of osteogenic proteins by chondrocytes. Int J Biochem Cell Biol 2003;35:1323-40.
35. Takegami K, Thonar EJ, An HS, et al. Osteogenic protein-1 enhances matrix replenishment by intervertebral disc cells previously exposed to interleukin-1. Spine 2002;15:27:1318-25.
36. Zhang Y, An HS, Toofanfard M, et al. Low-dose interleukin-1 partially counteracts osteogenic protein-1-induced proteoglycan synthesis by adult bovine intervertebral disk cells. Am J Phys Med Rehabil 2005;84:322-9.
37. Lidslot L, Olmarker K, Kayama S, et al. Nucleus pulposus inhibits the axonal outgrowth of cultured dorsal root ganglion cells. Eur Spine J 2000;9:8-13.
38. Lein P, Johnson M, Guo X, et al. Osteogenic protein-1 induces dendritic growth in rat sympathetic neurons. Neuron 1995;15:597-605.
39. Le Roux P, Behar S, Higgins D, et al. OP-1 enhances dendritic growth from cerebral cortical neurons in vitro. Exp Neurol 1999;160:151-63.