Safety of recombinant human bone morphogenetic protein-2 after spinal laminectomy in the dog

Spine

Volumn 24, Issue 8, 1999, Pages 747-754

  Meyer Jr , Ralph A ^a   Gruber, Helen E ^a   Howard, Brian A ^a   Tabor Jr , Owen B ^a   Murakami, Takanori ^a   Kwiatkowski, Timothy C ^a   Wozney, John M ^b   Hanley Jr , Edward N ^a  

^a CAROLINAS MEDICAL CENTER   (United States)

^b PFIZER INC   (United States)

Author keywords

Bone morphogenetic protein; Dogs; Dura; Laminectomy; Spinal cord; Vertebrae

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BONE GRAFT; BONE TRANSPLANTATION; DOG; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; LAMINECTOMY; LUMBAR PUNCTURE; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; REGENERATION;

ADMINISTRATION, TOPICAL; ANIMALS; BONE MORPHOGENETIC PROTEINS; CALCIFICATION, PHYSIOLOGIC; DISEASE MODELS, ANIMAL; DOGS; DURA MATER; FOLLOW-UP STUDIES; LAMINECTOMY; LUMBAR VERTEBRAE; RANDOM ALLOCATION; RECOMBINANT PROTEINS; SAFETY; TOMOGRAPHY, X-RAY COMPUTED; TRANSFORMING GROWTH FACTOR BETA;

EID: 0345004160     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-199904150-00004     Document Type: Article

References (12)

1. Cotler JM, Star AM. Complications of spinal fusions. In: Cotler JM, Cotler HB, eds. Spinal Fusion: Science and Technique. New York: Springer-Verlag, 1990:361-87.
2. David SM, Gruber HE, Meyer RA Jr, et al. Lumbar spinal fusion using recombinant human bone morphogenetic protein (rhBMP-2): A randomized, blinded and controlled study. Spine 1999, in press.
3. Ebendal T, Bengtsson H, Soderstrom S. Bone morphogenetic proteins and their receptors: Potential functions in the brain. J Neurosci Res 1998;51:139-46.
4. Gruber HE, Stasky AA. Large specimen bone embedment and cement line staining. Biotech Histochem 1997;72:198-201.
5. Johnson EE, Urist MR, Finerman GA. Resistant nonunions and partial or complete segmental defects of long bones. Treatment with implants of a composite of human bone morphogenetic protein (BMP) and autolyzed, antigen-extracted, allogeneic (AAA) bone. Clin Orthop 1992;277:229-37.
6. Kanatani M, Sugimoto T, Kaji H et al. Stimulatory effect of bone morphogenetic protein-2 on osteoclast-like cell formation and bone-resorbing activity. J Bone Miner Res 1995;10:1681-90.
7. LaRocca H, MacNab I. The laminectomy membrane: Studies in its evolution, characteristics, effects and prophylaxis in dogs. J Bone Joint Surg [Br] 1974;56B: 545-50.
8. Lovell TP, Dawson EG, Nilsson OS, Urist MR. Augmentation of spinal fusion with bone morphogenetic protein in dogs. Clin Orthop 1989;243:266-74.
9. Muschler GF, Hyodo A, Manning T, Kambic H, Easley K. Evaluation of human bone morphogenetic protein 2 in a canine spinal fusion model. Clin Orthop 1994;308:229-40.
10. Sandhu HS, Kanim LEA, Kabo JM, et al. Evaluation of rhBMP-2 with an OPLA carrier in a canine posterolateral (transverse process) spinal fusion model. Spine 1995;20:2669-82.
11. Schimandle JH, Boden SD, Hurton WC. Experimental spinal fusion with recombinant human bone morphogenetic protein-2. Spine 1995;20: 1326-37.
12. Yasko AW, Lane JM, Fellinger EJ, Rosen V, Wozney JM, Wang EA: The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). J Bone Joint Surg [Am] 1992;74A:659-70.