Mouse MCP1 C-terminus inhibits human MCP1-induced chemotaxis and BBB compromise

Journal of Neurochemistry

Volumn 118, Issue 2, 2011, Pages 215-223

  Yao, Yao ^a   Tsirka, Stella E ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

blood brain barrier; chemokine; microglia

Indexed keywords

CARBOXY TERMINAL TELOPEPTIDE; CHEMOKINE RECEPTOR CCR2; CHIMERIC PROTEIN; F ACTIN; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN ZO1; RAC1 PROTEIN;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; CHEMOTAXIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; LAMELLIPODIUM; MALE; MICROVASCULAR ENDOTHELIAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

ANIMALS; BLOOD-BRAIN BARRIER; CELL LINE; CELL MIGRATION INHIBITION; CELLS, CULTURED; CHEMOKINE CCL2; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PEPTIDE FRAGMENTS;

RODENTIA;

EID: 79959924522     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07319.x     Document Type: Article

References (26)

1. Bartoli C., Civatte M., Pellissier J. F., and, Figarella-Branger D., (2001) CCR2A and CCR2B, the two isoforms of the monocyte chemoattractant protein-1 receptor are up-regulated and expressed by different cell subsets in idiopathic inflammatory myopathies. Acta Neuropathol. 102, 385-392. (Pubitemid 32894710)
2. Biber K., Zuurman M. W., Homan H., and, Boddeke H. W. G. M., (2003) Expression of L-CCR in HEK 293 cells reveals functional responses to CCL2, CCL5, CCL7, and CCL8. J. Leukocyte Biol. 74, 243-251. (Pubitemid 38040421)
3. Calabria A. R., Weidenfeller C., Jones A. R., de Vries H. E., and, Shusta E. V., (2006) Puromycin-purified rat brain microvascular endothelial cell cultures exhibit improved barrier properties in response to glucocorticoid induction. J. Neurochem. 97, 922-933.
4. Charo I. F., Myers S. J., Herman A., Franci C., Connolly A. J., and, Coughlin S. R., (1994) Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc. Natl Acad. Sci. USA 91, 2752-2756. (Pubitemid 24139426)
5. Chen Z., Gore B. B., Long H., Ma L., and, Tessier-Lavigne M., (2008) Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion. Neuron 58, 325-332. (Pubitemid 351615180)
6. Deli M. A., Abraham C. S., Niwa M., and, Falus A., (2003) N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine increases the permeability of primary mouse cerebral endothelial cell monolayers. Inflamm. Res. 52 (Suppl 1), S39-S40. (Pubitemid 36470050)
7. Dimitrijevic O. B., Stamatovic S. M., Keep R. F., and, Andjelkovic A. V., (2006) Effects of the chemokine CCL2 on blood-brain barrier permeability during ischemia-reperfusion injury. J. Cereb. Blood Flow Metab. 26, 797-810.
8. Ernst C. A., Zhang Y. J., Hancock P. R., Rutledge B. J., Corless C. L., and, Rollins B. J., (1994) Biochemical and biologic characterization of murine monocyte chemoattractant protein-1. Identification of two functional domains. J. Immunol. 152, 3541-3549. (Pubitemid 24098051)
9. Giulian D., and, Baker T. J., (1986) Characterization of ameboid microglia isolated from developing mammalian brain. J. Neurosci. 6, 2163-2178. (Pubitemid 16043659)
10. Haedicke J., Brown C., and, Naghavi M. H., (2009) The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection. Proc. Natl Acad. Sci. USA 106, 14040-14045.
11. Holmberg J., Clarke D. L., and, Frisen J., (2000) Regulation of repulsion versus adhesion by different splice forms of an Eph receptor. Nature 408, 203-206.
12. Hoogewerf A. J., Kuschert G. S., Proudfoot A. E., Borlat F., Clark-Lewis I., Power C. A., and, Wells T. N., (1997) Glycosaminoglycans mediate cell surface oligomerization of chemokines. Biochemistry 36, 13570-13578. (Pubitemid 27481603)
13. Lau E. K., Paavola C. D., Johnson Z., Gaudry J. P., Geretti E., Borlat F., Kungl A. J., Proudfoot A. E., and, Handel T. M., (2004) Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo. J. Biol. Chem. 279, 22294-22305. (Pubitemid 38679426)
14. Maghazachi A. A., (2000) Intracellular signaling events at the leading edge of migrating cells. Int. J. Biochem. Cell Biol. 32, 931-943.
15. Pankov R., Endo Y., Even-Ram S., Araki M., Clark K., Cukierman E., Matsumoto K., and, Yamada K. M., (2005) A Rac switch regulates random versus directionally persistent cell migration. J. Cell Biol. 170, 793-802. (Pubitemid 41242111)
16. Sheehan J. J., Zhou C., Gravanis I., Rogove A. D., Wu Y. P., Bogenhagen D. F., and, Tsirka S. E., (2007) Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice. J. Neurosci. 27, 1738-1745. (Pubitemid 46280067)
17. Stamatovic S. M., Keep R. F., Kunkel S. L., and, Andjelkovic A. V., (2003) Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase. J. Cell Sci. 116, 4615-4628. (Pubitemid 37461616)
18. Stamatovic S. M., Shakui P., Keep R. F., Moore B. B., Kunkel S. L., Van Rooijen N., and, Andjelkovic A. V., (2005) Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability. J. Cereb. Blood Flow Metab. 25, 593-606. (Pubitemid 40562932)
19. Stamatovic S. M., Dimitrijevic O. B., Keep R. F., and, Andjelkovic A. V., (2006) Protein kinase Calpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability. J. Biol. Chem. 281, 8379-8388. (Pubitemid 43847939)
20. Terashima Y., Onai N., Murai M., et al. (2005) Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis. Nat. Immunol. 6, 827-835. (Pubitemid 43090469)
21. Tsukamoto T., and, Nigam S., (1997) Tight junction proteins form large complexes and associate with the cytoskeleton in an ATP depletion model for reversible junction assembly. J. Biol. Chem. 272, 16133-16139. (Pubitemid 27276427)
22. Tsukamoto T., and, Nigam S., (1999) Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins. Am. J. Physiol. 276, F737-F750. (Pubitemid 29249693)
23. Wang L., Fuster M., Sriramarao P., and, Esko J. D., (2005) Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses. Nat. Immunol. 6, 902-910. (Pubitemid 43090445)
24. Yao Y., and, Tsirka S. E., (2010) The C terminus of mouse monocyte chemoattractant protein 1 (MCP1) mediates MCP1 dimerization while blocking its chemotactic potency. J. Biol. Chem. 285, 31509-31516.
25. Yao Y., and, Tsirka S. E., (2011) Truncation of monocyte chemoattractant protein-1 by plasmin promotes blood-brain barrier disruption. J. Cell Sci. 124, 1486-1495.
26. Zhang Y., and, Rollins B. J., (1995) A dominant negative inhibitor indicates that monocyte chemoattractant protein 1 functions as a dimer. Mol. Cell. Biol. 15, 4851-4855.