Prevention of cataract by pyruvate in experimentally diabetic mice

Molecular and Cellular Biochemistry

Volumn 269, Issue 1, 2005, Pages 115-120

  Hegde, K R ^a   Varma, S D ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Antioxidant; Diabetic cataract; Glycation; Pyruvate

Indexed keywords

ALDEHYDE REDUCTASE; GLUCOSE; GLUTATHIONE; GLYCOSYLATED PROTEIN; PYRUVIC ACID; SORBITOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CARBOHYDRATE SYNTHESIS; CATARACT; CATARACTOGENESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETES MELLITUS; ENZYME ACTIVITY; ENZYME KINETICS; EYE PROTECTION; GLYCATION; LENS; MOUSE; NONHUMAN; OSMOSIS; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN GLYCOSYLATION;

ANIMALS; CATARACT; DIABETES MELLITUS, EXPERIMENTAL; GLYCOSYLATION; LENS, CRYSTALLINE; MICE; MICE, INBRED STRAINS; PROTEINS; PYRUVIC ACID; SORBITOL;

EID: 14244253540     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11010-005-3087-z     Document Type: Article

References (27)

1. Kahn HA, Leibowitz HM, Ganley JP, Kini MM, Colton T, Nickerson RS, Dawber TR: The Framingham eye study I. Outline and major prevalence finding. Am J Epidemiol 106: 17-32, 1977
2. Stark WJ Jr, Maumenee AE, Fagadau W, Datiles M, Baker CC, Worthen D, Klein P, Auer C: Cystoid macular edema in pseudophakia. Surv Ophthalmol 28 suppl: 442-451, 1984 10.1016/0039-6257(84)90226-1
3. Fine BS, Brucker AJ: Macular edema and Cystoid macular edema. Am J Ophthalmol 92: 466-481, 1981
4. Clayman HM, Jaffe NS, Light DS, Jaffe MS, Cassady JC: Intraocular lenses, axial length, and retinal detachment. Am J Ophthalmol 92: 778-780, 1981
5. Smith PW, Stark WJ, Maumenee AE, Enger CL, Michels RG, Glaser BM, Bonham RD: Retinal detachment after cataract extraction with posterior chamber intraocular lens. Ophthalmology 94: 495-504, 1987
6. Kinoshita JH: Mechanisms initiating cataract formation. Invest Ophthalmol Vis Sci 13: 713-724, 1974
7. Varma SD, Mikuni I, Kinoshita JH: Flavonoids as inhibitors of lens aldose reductase. Science 188: 1215-1216, 1975
8. Varma SD, Mizuno A, Kinoshita JH: Diabetic cataracts and flavonoids. Science 195: 205-206, 1977
9. Chylack L, Henriques HF, Cheng HM, Tung WH: Efficacy of alrestatin, an aldose reductase inhibitor, in human diabetic and non-diabetic lenses. Ophthalmology 86: 1579-1585, 1979
10. Kador PF: The role of aldose reductase in the development of diabetic complications. Med Res Rev 8 3: 325-52, 1988
11. Hegde KR, Henein MG, Varma SD: Establishment of the mouse as a model animal for the study of diabetic cataracts. Ophthal Res 35: 12-18, 2003
12. Hegde KR, Henein MG, Varma SD: Establishment of mouse as an animal model for study of diabetic cataracts: Biochemical studies. diabetes, obesity and metabolism. 5: 113-119, 2003
13. Bhuyan KC, Bhuyan DK, Podos SM: Evidence of increased lipid peroxidation in cataracts. I. R. C. S. Med Sci 9: 126-127, 1981
14. Monnier VM, Steven VJ, Cerami A: Non-enzymatic glycosylation, sulphydryl oxidation and high molecular weight aggregates of lens proteins in experimental sugar cataracts. J Exptl Med 50: 1098-1117, 1979
15. Perry RE, Swamy MS, Abraham EC: Progressive changes in lens crystallin glycation and high molecular weight aggregate formation leading to cataract development in Streptozotocin-diabetic rats. Exp Eye Res 52: 205-212, 1987
16. Hegde KR, Varma SD: Cataracts in Experimentally Diabetic Mouse: Morphological and Apoptotic Changes. Diabetes Obesity and Metabolism, in press.
17. Hegde KR, Varma SD: Morphogenetic and apoptotic changes in diabetic cataract. Prevention by pyruvate. Mol Cell Biochem 262: 233-237, 2004
18. Varma SD, Devamanoharan PS, Rutzen AR, Ali AH, Henein M: Attenuation of galactose-induced cataract by pyruvate. Free Rad Res 30: 253-263, 1999
19. Zhao W, Devamanoharan PS, Henein M, Ali AH, Varma SD: Diabetes-induced biochemical changes in rat lens: Attenuation of cataractogenesis by pyruvate. Diabetes Obesity Metab 2: 165-174, 2000
20. Varma SD, Hegde K, Henein M: Oxidative damage to mouse lens in culture. Protective effect of pyruvate. Biochim Biophys Acta 1621: 246-252, 2003
21. Zhao W, Devamanoharan PS, Varma SD: Fructose induced deactivation of Glucose-6-phosphate dehydrogenase activity and its prevention by pyruvate: Implications in cataract prevention. Free Rad Res 29: 315-320, 1998
22. Varma SD, Ramachandran S, Devamanoharan PS, Morris SM, Ali AH: Prevention of oxidative damage to rat lens by pyruvate in vitro: Possible attenuation in vivo. Curr Eye Res 14: 643-649, 1995
23. Varma SD, Chand D, Sharma YR, Kuck JF, Richards RD: Oxidative stress on lens and cataract formation: Role of light and oxygen. Curr Eye Res 3: 35-57, 1984
24. Varma SD, Kumar S, Richards RD: Light-induced damage to ocular lens cation pump. Prevention by vitamin C. Proc Natl Acad Sci U.S.A. 76: 3504-3506, 1979
25. Zigler JS, Goosey JD: Singlet oxygen as a possible factor in human senile nuclear cataract development. Curr Eye Res 3: 59-65, 1984
26. Spector A: The search for a solution to senile cataracts. Proctor lecture. Invest Ophthalmol Vis Sci 25: 130-146, 1984
27. Blakytny R, Harding JJ: Glycation non-enzymatic glycosylation inactivates glutathione reductase. Biochem J 288: 303-307, 1992