Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice

Neurochemical Research

Volumn 36, Issue 7, 2011, Pages 1293-1303

  He, Xiaojuan ^a   Takahashi, Satoru ^b   Suzuki, Hiromi ^c   Hashikawa, Tsutomu ^c   Kulkarni, Ashok B ^d   Mikoshiba, Katsuhiko ^c   Ohshima, Toshio ^a  

^a WASEDA UNIVERSITY   (Japan)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

^c RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^d NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Conditional knockout mice; Cyclin dependent kinase 5; Hypomyelination; Oligodendrocyte differentiation

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CRE RECOMBINASE; CYCLIN DEPENDENT KINASE 5; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; TRANSCRIPTION FACTOR EMX1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; CYCLIN DEPENDENT KINASE 5 GENE; DOWN REGULATION; EMBRYO; GENE; GENE FREQUENCY; IN SITU HYBRIDIZATION; IN VIVO STUDY; KNOCKOUT MOUSE; MOUSE; MYELIN SHEATH; MYELINATION; NERVE CELL DIFFERENTIATION; NONHUMAN; OLIGODENDROGLIA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

2',3'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CEREBRAL CORTEX; CYCLIN-DEPENDENT KINASE 5; HOMEODOMAIN PROTEINS; MICE; MICE, KNOCKOUT; MYELIN SHEATH; NERVE TISSUE PROTEINS; NEURONS; OLIGODENDROGLIA; PHENOTYPE; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; TRANSCRIPTION FACTORS;

MUS;

EID: 79959908129     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-010-0391-0     Document Type: Article

References (41)

1. Dhavan R, Tsai LH (2001) A decade of Cdk5. Nat Rev Mol Cell Biol 2:749-759 (Pubitemid 33679837)
2. Smith D (2003) Cdk5 in neuroskeletal dynamics. Neurosignals 12:239-251
3. Tanaka T, Veeranna, Ohshima T et al (2001) Neuronal cyclin-dependent kinase 5 activity is critical for survival. Neuroscience 21:550-558 (Pubitemid 32107444)
4. Grant P, Sharma P, Pant HC et al (2001) Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism. Eur J Nerurosci 268:1534-1546 (Pubitemid 32862685)
5. Wu DC, Yu YP, Lee NTK et al (2000) The expression of Cdk5, p35, p39, and Cdk5 kinase activity in developing, adult, and aged rat brains. Neurochem Res 25:923-930
6. Ohshima T, Ward JM, Huh CG et al (1996) Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc Natl Acad Sci USA 93:11173-11178 (Pubitemid 26333137)
7. Ko J, Humbert S, Brorson T et al (2001) p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci 21:6758-6771 (Pubitemid 32781119)
8. Gilmore E, Ohshima T, Goffinet A et al (1998) Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex. J Neurosci 18:6370-6377 (Pubitemid 28373242)
9. Paglini G, Caceres A (2001) The role of the Cdk5-p35 kinase in neuronal development. Eur J Biochem 268:1528-1533 (Pubitemid 32862684)
10. Delalle I, Bhide PG, Caviness VS et al (1997) Temporal and spatial patterns of expression of p35, a regulatory subunit of cyclin-dependent kinase 5, in the nervous system of the mouse. J Neurocytol 26:283-296 (Pubitemid 27261221)
11. Lee JC, Mayer-Proschel M, Rao MS et al (2000) Gliogenesis in the central nervous system. Glia 30:105-121 (Pubitemid 30199425)
12. Baumann N, Pham-Dinh D (2001) Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiol Rev 81:871-928
13. Dana M, McTigue DM, Richa B et al (2008) The life, death, and replacement of oligodendrocytes in the adult CNS. J Neurochem 107:1-19
14. de Castro F, Bribián A (2005) The molecular orchestra of the migration of oligodendrocyte precursors during development. Brain Res Rev 49:227-241
15. Bradl M, Lassmann H (2010) Oligodendrocytes: biology and pathology. Acta Neuropathol 119:37-53
16. Richardson WD, Kessaris N, Pringle N (2006) Oligodendrocyte wars. Nat Rev Neurosci 7:11-18 (Pubitemid 41828927)
17. Tang XM, Strocchi P, Cambi F (1998) Changes in the activity of cdk2 and cdk5 accompany differentiation of rat primary oligodendrocytes. J Cell Biochem 68:128-137 (Pubitemid 27520117)
18. Miyamoto Y, Yamauchi J, Chan JR et al (2007) Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin. J Cell Sci 120:4355-4366
19. Takahashi S, Ohshima T, Hirasawa M et al (2010) Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration. Am J Pathol 176:320-329
20. Gorski JA, Talley T, Qiu M (2002) Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emxlexpressing lineage. J Neurosci 22(15):6309-6314 (Pubitemid 35386383)
21. Hirasawa M, Ohshima T, Takahashi S et al (2004) Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects. Proc Natl Acad Sci USA 101:6249-6254 (Pubitemid 38520560)
22. Iwasato T, Datwani A, Wolf AM et al (2000) Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex. Nature 406:726-731
23. Ohshima T, Hirasawa M, Tabata H et al (2007) Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. Development 134:2273-2282 (Pubitemid 47010016)
24. Araya R, Kudo M, Kawano M et al (2008) BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier. Mol Cell Neurosci 38:417-430
25. Billon N, Jolicoeur C, Tokumoto Y et al (2002) Normal timing of oligodendrocyte development depends on thyroid hormone receptor alpha 1 (TR#1). EMBO J 21:6452-6460 (Pubitemid 35448423)
26. Nancy EJ, Berman J, Johnson K et al (1997) Early generation of glia in the intermediate zone of the developing cerebral cortex. Dev Brain Res 101:149-164
27. Miller RH (2002) Regulation of oligodendrocyte development in the vertebrate CNS. Prog Neurobiol 67:451-467
28. Ventura RE, Goldman JE (2006) Telencephalic oligodendrocytes battle it out. Nat Neursci 9:153-154 (Pubitemid 43164530)
29. Rosales JL, Lee KY (2006) Extraneuronal roles of cyclindependent kinase 5. Bioessays 28:1023-1034
30. Rowitch DH (2004) Glial specification in the vertebrate neural tube. Nat Rev Neurosci 5:409-419
31. Johansson JU, Lilja L, Chen XL et al (2005) Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses. Mol Brain Res 138:215-227 (Pubitemid 41138041)
32. Dhariwala FA, Rajadhyaksha MS (2008) An unusual member of the Cdk family: Cdk5. Cell Mol Neurobiol 28:351-369
33. Gao C, Negash S, Wang HS (2001) Cdk5 mediates changes in morphology and promotes apoptosis of astrocytoma cells in response to heat shock. J Cell Sci 114:1145-1154
34. Mikoshiba K, Takamatsu K, Tsukada Y (1985) Altered myelinated fiber trajectory at various postnatal days in the cerebral cortex of reeler mice by immunohistochemical stain with MBP antiserum. Dev Neurosci 4:199-205 (Pubitemid 16164211)
35. Aikawa H, Nonaka I, Woo M et al (1988) Shaking rat Kawasaki (SRK): a new neurological mutant rat in the Wistar strain. Acta Neuropathol 76(4):366-372
36. Kikkawa S, Yamamoto T, Misaki K et al (2003) Missplicing resulting from a short deletion in the reelin gene causes reeler-like neuronal disorders in the mutant shaking rat Kawasaki. J Comp Neurol 463(3):303-315 (Pubitemid 36842398)
37. Turner CE (2000) Paxillin interactions. J Cell Sci 113:4139-4140
38. Wegner M (2008) A matter of identity: transcriptional control in oligodendrocytes. J Mol Neurosci 35:3-12
39. Nicolay DJ, Doucette JR, Nazarali AJ (2007) Transcriptional control of oligodendrogenesis. Glia 55:1287-1299 (Pubitemid 47328933)
40. Zhao XH, He XL, Han XL et al (2010) MicroRNA-mediated control of oligodendrocytes differentiation. Neuron 65:612-626
41. Dugas JC, Cuellar TL, Scholze A et al (2010) Dicer1 and miR- 219 are required for normal oligodendrocyte differentiation and myelination. Neuron 65:597-611