Is oral methadone better than placebo or other oral/transdermal opioids in the management of pain?

Palliative Medicine

Volumn 25, Issue 5, 2011, Pages 488-493

  Cherny, Nathan ^a  

^a SHAARE ZEDEK MEDICAL CENTER   (Israel)

Author keywords

methadone; Neoplasm; opioids; pain

Indexed keywords

FENTANYL; METHADONE; MORPHINE; OPIATE; PLACEBO;

ANALGESIC ACTIVITY; CANCER PAIN; CANCER PATIENT; COGNITION; CONFERENCE PAPER; DISEASE SEVERITY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG COST; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG WITHDRAWAL; HUMAN; LOW DRUG DOSE; NAUSEA; NEUROPATHIC PAIN; PAIN ASSESSMENT; PROGNOSIS; QUALITY OF LIFE; SEDATION; SIDE EFFECT; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT; XEROSTOMIA;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; ANALGESICS, OPIOID; HUMANS; METHADONE; NEOPLASMS; PAIN; PAIN MEASUREMENT; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 79959905882     PISSN: 02692163     EISSN: 1477030X     Source Type: Journal    
DOI: 10.1177/0269216310397687     Document Type: Conference Paper

References (52)

1. Cubero DI and Del Giglio A. Early switching from morphine to methadone is not improved by acetaminophen in the analgesia of oncologic patients: a prospective, randomized, double-blind, placebo-controlled study. Support Care Cancer 2010; 18: 235-42.
2. Compton PA, Ling W, Torrington MA. Lack of effect of chronic dextromethorphan on experimental pain tolerance in methadone-maintained patients. Addict Biol. 2008 ; 13: 393-402
3. Nicholson AB. Methadone for cancer pain. Cochrane Database Syst Rev 2007; CD003971.
4. Liu P, Foster G, Labadie R, Somoza E, Sharma A. Pharmacokinetic interaction between voriconazole and methadone at steady state in patients on methadone therapy. Antimicrob Agents Chemother. 2007 ; 51: 110-118 (Pubitemid 46047695)
5. Sandoval JA, Furlan AD, Mailis-Gagnon A. Oral methadone for chronic noncancer pain: a systematic literature review of reasons for administration, prescription patterns, effectiveness, and side effects. Clin J Pain. 2005 ; 21: 503-512 (Pubitemid 41527740)
6. Altier N, Dion D, Boulanger A, Choiniere M. Management of chronic neuropathic pain with methadone: a review of 13 cases. Clin J Pain. 2005 ; 21: 364-369 (Pubitemid 40881149)
7. Simoni RF, Cangiani LM, Pereira AM, Abreu MP, Cangiani LH, Zemi G. [Efficacy of intraoperative methadone and clonidine in pain control in the immediate postoperative period after the use of remifentanil]. Rev Bras Anestesiol. 2009 ; 59: 421-430
8. Janiri L, Martinotti G, Tonioni F, Ghelardini C, Nicolai R, Galeotti N, Mosconi L, Calvani M, Bartolini A, Iannoni E. Acetyl-L-carnitine in the management of pain during methadone withdrawal syndrome. Clin Neuropharmacol. 2009 ; 32: 35-40
9. Yuan CS, Foss JF, O'Connor M, Osinski J, Karrison T, Moss J, Roizen MF. Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial. JAMA. 2000 ; 283: 367-372 (Pubitemid 30051755)
10. Morley JS, Bridson J, Nash TP, Miles JB, White S, Makin MK. Low-dose methadone has an analgesic effect in neuropathic pain: a double-blind randomized controlled crossover trial. Palliat Med. 2003 ; 17: 576-587 (Pubitemid 37279338)
11. Rohrer Bley C, Neiger-Aeschbacher G, Busato A, Schatzmann U. Comparison of perioperative racemic methadone, levo-methadone and dextromoramide in cats using indicators of post-operative pain. Vet Anaesth Analg. 2004 ; 31: 175-182 (Pubitemid 40208642)
12. Yuan CS, Foss JF, O'Connor M, Osinski J, Karrison T, Moss J, Roizen MF. Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial. JAMA. 2000 ; 283: 367-372 (Pubitemid 30051755)
13. Martin CS, McGrady EM, Colquhoun A, Thorburn J. Extradural methadone and bupivacaine in labour. Br J Anaesth. 1990 ; 65: 330-332 (Pubitemid 20275616)
14. Moulin DE, Palma D, Watling C, Schulz V. Methadone in the management of intractable neuropathic noncancer pain. Can J Neurol Sci. 2005 ; 32: 340-343 (Pubitemid 41232808)
15. Bryson J, Tamber A, Seccareccia D, Zimmermann C. Methadone for treatment of cancer pain. Curr Oncol Rep. 2006 ; 8: 282-288 (Pubitemid 43970979)
16. Mercadante S, Porzio G, Ferrera P, Fulfaro F, Aielli F, Verna L, Villari P, Ficorella C, Gebbia V, Riina S, Casuccio A, Mangione S. Sustained-release oral morphine versus transdermal fentanyl and oral methadone in cancer pain management. Eur J Pain. 2008 ; 12: 1040-1046
17. Bruera E, Palmer JL, Bosnjak S, Rico MA, Moyano J, Sweeney C, Strasse F, Willey J, Bertolino M, Mathias C, Spruyt O, Fisch MJ. Methadone versus morphine as a first-line strong opioid for cancer pain: a randomized, double-blind study. J Clin Oncol. 2004 ; 22: 185-192 (Pubitemid 41095131)
18. Ventafridda V, Ripamonti C, Bianchi M, Sbanotto A, De Conno F. A randomized study on oral administration of morphine and methadone in the treatment of cancer pain. J Pain Symptom Manage. 1986 ; 1: 203-207 (Pubitemid 17215919)
19. Fisher K, Stiles C, Hagen NA. Characterization of the early pharmacodynamic profile of oral methadone for cancer-related breakthrough pain: a pilot study. J Pain Symptom Manage. 2004 ; 28: 619-625 (Pubitemid 39626108)
20. Dale O, Sheffels P, Kharasch ED. Bioavailabilities of rectal and oral methadone in healthy subjects. Br J Clin Pharmacol. 2004 ; 58: 156-162 (Pubitemid 39043995)
21. Nicholson AB. Methadone for cancer pain. Cochrane Database Systematic Rev 2004; CD003971.
22. Bianchi M, Clavenna A, Groff L, Zecca E, Ripamonti C. Diclofenac does not modify methadone bioavailability in cancer patients. J Pain Symptom Manage. 1999 ; 17: 227-229
23. Mercadante S, Casuccio A, Agnello A, Serretta R, Calderone L, Barresi L. Morphine versus methadone in the pain treatment of advanced-cancer patients followed up at home. J Clin Oncol. 1998 ; 16: 3656-3661 (Pubitemid 28506781)
24. Grochow L, Sheidler V, Grossman S, Green L, Enterline J. Does intravenous methadone provide longer lasting analgesia than intravenous morphine? A randomized, double-blind study. Pain. 1989 ; 38: 151-157 (Pubitemid 19212935)
25. Ferrer-Brechner T, Ganz P. Combination therapy with ibuprofen and methadone for chronic cancer pain. Am J Med. 1984 ; 77: 78-83 (Pubitemid 14050202)
26. Gourlay GK, Cherry DA, Cousins MJ. A comparative study of the efficacy and pharmacokinetics of oral methadone and morphine in the treatment of severe pain in patients with cancer. Pain. 1986 ; 25: 297-312 (Pubitemid 16085474)
27. Bruera E, Pereira J, Watanabe S, Belzile M, Kuehn N, Hanson J. Opioid rotation in patients with cancer pain. A retrospective comparison of dose ratios between methadone, hydromorphone, and morphine. Cancer. 1996 ; 78: 852-857 (Pubitemid 26268617)
28. Fainsinger R, Schoeller T, Bruera E. Methadone in the management of cancer pain: a review. Pain. 1993 ; 52: 137-147 (Pubitemid 23068182)
29. Watanabe S, Belzile M, Kuehn N, Hanson J, Bruera E. Capsules and suppositories of methadone for patients on high-dose opioids for cancer pain: clinical and economic considerations. Cancer Treat Rev. 1996 ; 22(Suppl. A): 131-136
30. Ripamonti C, De Conno F, Groff L, Belzile M, Pereira J, Hanson J, Bruera E. Equianalgesic dose/ratio between methadone and other opioid agonists in cancer pain: comparison of two clinical experiences. Ann Oncol. 1998 ; 9: 79-83 (Pubitemid 28125768)
31. Gagnon B, Bruera E. Differences in the ratios of morphine to methadone in patients with neuropathic pain versus non-neuropathic pain. J Pain Symptom Manage. 1999 ; 18: 120-125 (Pubitemid 29409440)
32. Hagen NA, Wasylenko E. Methadone: outpatient titration and monitoring strategies in cancer patients. J Pain Symptom Manage. 1999 ; 18: 369-375 (Pubitemid 29528473)
33. Gagnon B, Bruera E. Differences in the ratios of morphine to methadone in patients with neuropathic pain versus non-neuropathic pain. J Pain Symptom Manage. 1999 ; 18: 120-125 (Pubitemid 29409440)
34. Davis MP, Walsh D. Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration. Support Care Cancer. 2001 ; 9: 73-83 (Pubitemid 32246453)
35. Bruera E, Sweeney C. Methadone use in cancer patients with pain: a review. J Palliat Med. 2002 ; 5: 127-138 (Pubitemid 34111584)
36. Ripamonti C, Bianchi M. The use of methadone for cancer pain. Hematol Oncol Clin North Am. 2002 ; 16: 543-555 (Pubitemid 34827367)
37. Ripamonti C, Zecca E, Bruera E. An update on the clinical use of methadone for cancer pain. Pain. 1997 ; 70: 109-115 (Pubitemid 27179621)
38. Mancini I, Lossignol DA, Body JJ. Opioid switch to oral methadone in cancer pain. Curr Opin Oncol. 2000 ; 12: 308-313 (Pubitemid 32043967)
39. Nicholson A. Methadone for cancer pain. Cochrane Database Syst Rev. 2004 ; 2: CD003971 - CD003971
40. Toombs JD, Kral LA. Methadone treatment for pain states. Am Fam Physician. 2005 ; 71: 1353-1358 (Pubitemid 40489118)
41. Soares LG. Methadone for cancer pain: what have we learned from clinical studies?. Am J Hosp Palliat Care. 2005 ; 22: 223-227 (Pubitemid 40745021)
42. Blinderman CD, Sekine R, Zhang B, Nillson M, Shaiova L. Methadone as an analgesic for patients with chronic pain in methadone maintenance treatment programs (MMTPs). J Opioid Manag. 2009 ; 5: 107-114
43. Walker PW, Palla S, Pei BL, Kaur G, Zhang K, Hanohano J, Munsell M, Bruera E. Switching from methadone to a different opioid: what is the equianalgesic dose ratio?. J Palliat Med. 2008 ; 11: 1103-1108
44. Terpening CM, Johnson WM. Methadone as an analgesic: a review of the risks and benefits. W V Med J. 2007 ; 103: 14-18
45. Sekine R, Obbens EA, Coyle N and Inturrisi CE. The Successful Use of Parenteral Methadone in a Patient with a Prolonged QTc Interval. J Pain Symptom Manage 2007; 34: 566-569. (Pubitemid 47633894)
46. Ehret GB, Desmeules JA, Broers B. Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology. Expert Opin Drug Saf. 2007 ; 6: 289-303 (Pubitemid 46767636)
47. Mannino R, Coyne P, Swainey C, Hansen LA, Lyckholm L. Methadone for cancer-related neuropathic pain: a review of the literature. J Opioid Manag. 2006 ; 2: 269-276
48. Griffie J, Coyne P, Coyle N. Difficult cases in pain management: use of methadone in a multifactorial approach. Clin J Oncol Nurs. 2006 ; 10: 45-49
49. Moryl N, Kogan M, Comfort C, Obbens E. Methadone in the treatment of pain and terminal delirum in advanced cancer patients. Palliat Support Care. 2005 ; 3: 311-317
50. Weschules DJ, Bain KT. A systematic review of opioid conversion ratios used with methadone for the treatment of pain. Pain Med. 2008 ; 9: 595-612
51. Weschules DJ, Bain KT, Richeimer S. Actual and potential drug interactions associated with methadone. Pain Med. 2008 ; 9: 315-344 (Pubitemid 351467888)
52. Sekine R, Obbens EA, Coyle N, Inturrisi CE. The successful use of parenteral methadone in a patient with a prolonged QTc interval. J Pain Symptom Manage. 2007 ; 34: 566-569 (Pubitemid 47633894)