Structure and mechanism of human UDP-glucose 6-dehydrogenase

Journal of Biological Chemistry

Volumn 286, Issue 27, 2011, Pages 23877-23887

  Egger, Sigrid ^a   Chaikuad, Apirat ^b   Kavanagh, Kathryn L ^b   Oppermann, Udo ^b   Nidetzky, Bernd ^a  

^a GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BINDING DOMAIN; CANCER THERAPY; CATALYTIC NUCLEOPHILES; COENZYME BINDING; DOMAIN MOTIONS; GLYCOSAMINOGLYCANS; HOMODIMERS; HYALURONAN; IN-CONTROL; INTER-DOMAIN; LIGAND BINDING; MATRIX; N-TERMINALS; PHYSIOLOGICAL REACTIONS; QUATERNARY STRUCTURE; REACTION COORDINATES; RIGID BODY; SIDE-CHAINS; STEADY STATE; STOPPED-FLOW KINETICS; STRUCTURAL CHARACTERIZATION; TERNARY COMPLEX; THIOESTERS; THIOLATES; TUMOR PROGRESSIONS; UDP-GLUCOSE; UDP-GLUCURONIC ACID;

ALDEHYDES; GLUCOSE; HYDROGELS; OLIGOMERS; ORGANIC COMPOUNDS; OXIDATION; SYNTHESIS (CHEMICAL);

REACTION INTERMEDIATES;

ASPARAGINE; CYSTEINE; GLUTAMINE; LEUCINE; SERINE; TYROSINE; URIDINE DIPHOSPHATE GLUCOSE DEHYDROGENASE;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME RELEASE; HUMAN; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; PROTON TRANSPORT; STEADY STATE;

CATALYSIS; COENZYMES; HUMANS; NAD; OXIDATION-REDUCTION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; URIDINE DIPHOSPHATE GLUCOSE DEHYDROGENASE;

EID: 79959899426     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.234682     Document Type: Article

References (49)

1. Bharadwaj, A. G., Rector, K., and Simpson, M. A. (2007) J. Biol. Chem. 282, 20561-20572
2. Lin, S. L., Chang, D., and Ying, S. Y. (2007) Carcinogenesis 28, 310-320
3. Slomiany, M. G., and Toole, B. P. (2009) in Hyaluronan in Cancer Biology (Stern, R., ed) pp. 19-35, Academic Press, San Diego
4. Tammi, R. H., Kultti, A., Kosma, V. M., Pirinen, R., Auvinen, P., and Tammi, M. I. (2008) Semin. Cancer Biol. 18, 288-295
5. Toole, B. P., and Slomiany, M. G. (2008) Semin. Cancer Biol. 18, 244-250
6. Varki, A., Cummings, R. D., Esko, J. D., Freeze, H. H., Stanley, P., Bertozzi, C. R., Hart, G. W., and Etzler, M. E. (2009) Essentials of Glycobiology, 2nd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
7. Feingold, D. S., and Franzen, J. S. (1981) Trends Biochem. Sci. 6, 103-105
8. Ge, X., Campbell, R. E., van de Rijn, I., and Tanner, M. E. (1998) J. Am. Chem. Soc. 120, 6613-6614
9. Sommer, B. J., Barycki, J. J., and Simpson, M. A. (2004) J. Biol. Chem. 279, 23590-23596
10. Auvinen, P., Tammi, R., Parkkinen, J., Tammi, M., Agren, U., Johansson, R., Hirvikoski, P., Eskelinen, M., and Kosma, V. M. (2000) Am. J. Pathol. 156, 529-536
11. Huh, J. W., Choi, M. M., Yang, S. J., Yoon, S. Y., Choi, S. Y., and Cho, S. W. (2005) Biotechnol. Lett. 27, 1229-1232
12. Simpson, M. A., Wilson, C. M., and McCarthy, J. B. (2002) Am. J. Pathol. 161, 849-857
13. Wang, T. P., Pan, Y. R., Fu, C. Y., and Chang, H. Y. (2010) Exp. Cell Res. 316, 2893-2902
14. Wei, Q., Galbenus, R., Raza, A., Cerny, R. L., and Simpson, M. A. (2009) Cancer Res. 69, 2332-2339
15. Huang, D., Casale, G. P., Tian, J., Lele, S. M., Pisarev, V. M., Simpson, M. A., and Hemstreet, G. P., 3rd (2010) Int. J. Cancer 126, 315-327
16. Egger, S., Chaikuad, A., Kavanagh, K. L., Oppermann, U., and Nidetzky, B. (2010) Biochem. Soc. Trans. 38, 1378-1385
17. Campbell, R. E., Mosimann, S. C., van De Rijn, I., Tanner, M. E., and Strynadka, N. C. (2000) Biochemistry 39, 7012-7023
18. Campbell, R. E., Sala, R. F., van de Rijn, I., and Tanner, M. E. (1997) J. Biol. Chem. 272, 3416-3422
19. Campbell, R. E., and Tanner, M. E. (1997) Angew. Chem. Int. Ed. Engl. 36, 3
20. Campbell, R. E., and Tanner, M. E. (1999) J. Org. Chem. 64, 9487-9492
21. Ge, X., Penney, L. C., van de Rijn, I., and Tanner, M. E. (2004) Eur. J. Biochem. 271, 14-22
22. Ordman, A. B., and Kirkwood, S. (1977) Biochim. Biophys. Acta 481, 25-32
23. Schiller, J. G., Bowser, A. M., and Feingold, D. S. (1972) Carbohydr. Res. 21, 249-253
24. Strominger, J. L., Kalckar, H. M., Axelrod, J., and Maxwell, E. S. (1954) J. Am. Chem. Soc. 76, 6411-6412
25. Collaborative Computational Project No. 4 (1994) Acta Crystallogr. D Biol. Crystallogr. 50, 760-763
26. Leslie, A. G. (1999) Acta Crystallogr. D Biol. Crystallogr. 55, 1696-1702
27. McCoy, A. J. (2007) Acta Crystallogr. D Biol. Crystallogr. 63, 32-41
28. Emsley, P., and Cowtan, K. (2004) Acta Crystallogr. D Biol. Crystallogr. 60, 2126-2132
29. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. D Biol. Crystallogr. 53, 240-255
30. Klimacek, M., and Nidetzky, B. (2010) Biochem. J. 425, 455-463
31. Pival, S. L., Klimacek, M., and Nidetzky, B. (2009) Biochem. J. 421, 43-49
32. Niesen, F. H., Berglund, H., and Vedadi, M. (2007) Nat. Protoc. 2, 2212-2221
33. Huh, J. W., Yang, S. J., Hwang, E. Y., Choi, M. M., Lee, H. J., Kim, E. A., Choi, S. Y., Choi, J., Hong, H. N., and Cho, S. W. (2007) J. Biochem. Mol. Biol. 40, 690-696
34. Lee, H. S., Son, Y. J., Chong, S. H., Bae, J. Y., Leem, C. H., Jang, Y. J., and Choe, H. (2009) Arch. Biochem. Biophys. 486, 35-43
35. Hayward, S., Kitao, A., and Berendsen, H. J. (1997) Proteins 27, 425-437
36. Traut, T. W. (1994) Mol. Cell. Biochem. 140, 1-22
37. Yamada, K., Hara, N., Shibata, T., Osago, H., and Tsuchiya, M. (2006) Anal. Biochem. 352, 282-285
38. Yang, H., Yang, T., Baur, J. A., Perez, E., Matsui, T., Carmona, J. J., Lamming, D. W., Souza-Pinto, N. C., Bohr, V. A., Rosenzweig, A., de Cabo, R., Sauve, A. A., and Sinclair, D. A. (2007) Cell 130, 1095-1107
39. Ordman, A. B., and Kirkwood, S. (1977) J. Biol. Chem. 252, 1320-1326
40. Adams, M. J., Ellis, G. H., Gover, S., Naylor, C. E., and Phillips, C. (1994) Structure 2, 651-668
41. Zhang, L., Chooback, L., and Cook, P. F. (1999) Biochemistry 38, 11231-11238
42. Easley, K. E., Sommer, B. J., Boanca, G., Barycki, J. J., and Simpson, M. A. (2007) Biochemistry 46, 369-378
43. Steinmetz, C. G., Xie, P., Weiner, H., and Hurley, T. D. (1997) Structure 5, 701-711
44. Graham, C. E., Brocklehurst, K., Pickersgill, R. W., and Warren, M. J. (2006) Biochem. J. 394, 67-75
45. Marchal, S., Rahuel-Clermont, S., and Branlant, G. (2000) Biochemistry 39, 3327-3335
46. Day, J. M., Tutill, H. J., Purohit, A., and Reed, M. J. (2008) Endocr. Relat. Cancer 15, 665-692
47. Ge, X., Wakim, B., and Sem, D. S. (2008) J. Med. Chem. 51, 4571-4580
48. Singh, R., and Mozzarelli, A. (2009) Methods Mol. Biol. 575, 93-122
49. Vander Jagt, D. L., Deck, L. M., and Royer, R. E. (2000) Curr. Med. Chem. 7, 479-498