Application of hydrotropy to transdermal formulations: Hydrotropic solubilization of polyol fatty acid monoesters in water and enhancement effect on skin permeation of 5-FU

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 8, 2011, Pages 1008-1014

  Takahashi, Koichi ^a   Komai, Megumi ^a   Kinoshita, Natsumi ^a   Nakamura, Emi ^a   Hou, Xiao Long ^a   Takatani Nakase, Tomoka ^a   Kawase, Masaya ^b  

^a MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^b NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

5 fluorouracil; Hydrotropy; Penetration enhancer; Percutaneous absorption; Sodium salicylate

Indexed keywords

ALCOHOL; BENZOIC ACID; FLUOROURACIL; HYDROTROPE; PENETRATION ENHANCING AGENT; POLYOL FATTY ACID ESTER; PROPYLENE GLYCOL; SALICYLATE SODIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG PENETRATION; DRUG SOLUBILITY; MALE; MICELLE; NEAR INFRARED SPECTROSCOPY; NONHUMAN; PARTICLE SIZE; PHOTOMETRY; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SKIN PERMEABILITY; SOLUBILIZATION; SURFACE TENSION;

ADMINISTRATION, CUTANEOUS; ANIMALS; CAPRYLATES; ESTERS; FLUOROURACIL; MALE; PARTICLE SIZE; POLYMERS; PROPYLENE GLYCOL; RATS; RATS, HAIRLESS; SKIN; SKIN ABSORPTION; SODIUM BENZOATE; SODIUM SALICYLATE; SOLUBILITY; SURFACE TENSION; WETTABILITY;

EID: 79959872393     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01308.x     Document Type: Article

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