New muramyl dipeptide (MDP) mimics without the carbohydrate moiety as potential adjuvant candidates for a therapeutic hepatitis B vaccine (HBV)

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 14, 2011, Pages 4292-4295

  Zhao, Nan ^a   Ma, Yao ^a   Zhang, Shengmei ^a   Fang, Xin ^b   Liang, Zhenglun ^b   Liu, Gang ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b NATIONAL INSTITUTE FOR THE CONTROL OF PHARMACEUTICAL AND BIOLOGICAL PRODUCTS   (China)

Author keywords

Adjuvanticity; HBV; MDP mimics; Solid phase synthesis

Indexed keywords

CARBOHYDRATE; EPITOPE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; ISOLEUCYLPROLYLGLUTAMINYLSERYLLEUCYLASPARTYLSERYLTRYPTOPHANYLTRYPTOPHANYLTHREONYLSERYL LEUCINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MURAMYL DIPEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGENICITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENTIATION; DRUG SCREENING; EX VIVO STUDY; IMMUNOREACTIVITY; MOUSE; NONHUMAN; SOLID PHASE SYNTHESIS;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ADJUVANTS, IMMUNOLOGIC; AMINO ACID SEQUENCE; ANIMALS; CARBOHYDRATES; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VACCINES; MICE; MICE, INBRED BALB C; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

HEPATITIS B VIRUS; MUS;

EID: 79959862307     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.056     Document Type: Article

References (20)

1. D. Bhattacharya, and C.L. Thio Clin. Infect. Dis. 51 2010 1201
2. M. Marie-Louise, D. Qiang, and M.B. Maryline J. Hepatol. 54 2011 1286
3. M. Singh, and D. O' Hagan Nat. Biotechnol. 17 1999 1075
4. C.K. Hui, and G.K.K. Lau Int. J. Med. Sci. 2 2005 24
5. F. Ellouz, A. Adam, R. Ciorbaru, and E. Lederer Biochem. Biophys. Res. Commun. 59 1974 1317
6. S. Kotani, Y. Watanabe, F. Kinoshita, T. Shimono, I. Morisaki, T. Shiba, S. Kusumoto, Y. Tarumi, and K. Ikenaka Biken J. 18 1975 105
7. C. Carelli, F. Audibert, and L. Chedid Infect. Immun. 33 1981 312
8. G. Riveau, K. Masek, M. Parant, and L. Chedid J. Exp. Med. 152 1980 869
9. M. Ghada, W.C. Anthony, D. Jean-Philippe, and M.B. Gillian J. Med. Chem. 39 1996 4483
10. M. Parant, F. Parant, L. Chedid, A. Yapo, J.F. Petit, and E. Lederer Int. J. Immunopharmacol. 1 1979 35
11. Y. Hong-Zhen, X. Song, L. Xue-Yan, Z. Suo-De, L. Zheng-Lun, L. Bai-He, B. Jin-Ye, J. Chao, D. Jian, C. Gui-Fang, and L. Gang J. Med. Chem. 48 2005 5112
12. Y.Z. Chen, G. Liu, S. Senju, Q. Wang, A. Irie, M. Haruta, M. Matsui, F. Yasui, M. Kohara, and Y. Nishimura Int. J. Immunopathol. Pharmacol. 23 2010 165
13. A. Adam, and E. Lederer Med. Res. Rev. 4 1984 111
14. P. Pristovsek, J. Kidric, and D. Hadzi J. Chem. Inf. Comput. Sci. 37 1997 971
15. P. Pristovsek, J. Kidric, and D. Hadzi J. Chem. Inf. Comput. Sci. 35 1995 633
16. N. Inohara, Y. Ogura, A. Fontalba, O. Gutierrez, F. Pons, J. Crespo, K. Fukase, S. Inamura, S. Kusumoto, M. Hashimoto, S.J. Foster, A.P. Moran, J.L. Fernandez-Luna, and G. Nunez J. Biol. Chem. 278 2003 5509
17. S.E. Girardin, I.G. Boneca, J. Viala, M. Chamaillard, A. Labigne, G. Thomas, D.J. Philpott, and P.J. Sansonetti J. Biol. Chem. 278 2003 8869
18. N. Inohara, and G. Nunez Nat. Rev. Immunol. 3 2003 371
19. K.S. Kobayashi, M. Chamaillard, Y. Ogura, O. Henegariu, N. Inohara, G. Nunez, and R.A. Flavell Science 307 2005 731
20. J. Uehori, K. Fukase, T. Akazawa, S. Uematsu, S. Akira, K. Funami, M. Shingai, M. Matsumoto, I. Azuma, K. Toyoshima, S. Kusumoto, and T. Seya J. Immunol. 174 2005 7096