Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3)

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 14, 2011, Pages 4255-4258

  Kuduk, Scott D ^a   Chang, Ronald K ^a   Di Marco, Christina N ^a   Dipardo, Robert M ^a   Cook, Sean P ^a   Cato, Matthew J ^a   Jovanovska, Aneta ^a   Urban, Mark O ^a   Leitl, Michael ^a   Spencer, Robert H ^a   Kane, Stefanie A ^a   Hartman, George D ^a   Bilodeau, Mark T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

ASIC3; Blood to plasma; Non amidine; Pain

Indexed keywords

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 3; ACID SENSING ION CHANNEL 3 INHIBITOR; ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR; AMIDINE; AMINE; ANALGESIC AGENT; BENZOTHIOPHENE METHYL AMINE DERIVATIVE; DOPAMINE RECEPTOR; ION TRANSPORT AFFECTING AGENT; MUSCARINIC RECEPTOR; NAPROXEN; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; DEPROTECTION REACTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MALE; NONHUMAN; PAIN; RAT; SONOGASHIRA REACTION; STRUCTURE ACTIVITY RELATION;

AMIDINES; AMILORIDE; ANIMALS; NERVE TISSUE PROTEINS; RATS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79959861355     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.064     Document Type: Article

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