Synthesis, structure-activity relationship, and pharmacological profile of analogs of the ASIC-3 inhibitor A-317567

ACS Chemical Neuroscience

Volumn 1, Issue 1, 2010, Pages 19-24

  Kuduk, Scott D ^a   Di Marco, Christina N ^a   Bodmer Narkevitch, Vera ^a   Cook, Sean P ^a   Cato, Matthew J ^a   Jovanovska, Aneta ^a   Urban, Mark O ^a   Leitl, Michael ^a   Sain, Nova ^a   Liang, Annie ^a   Spence, Robert H ^a   Kane, Stefanie A ^a   Hartman, George D ^a   Bilodeau, Mark T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Acid sensing; ASIC 3; Degenerin; Ion channel; Pain

Indexed keywords

A 317567; ACID SENSING ION CHANNEL 3 INHIBITOR; ANALGESIC AGENT; IODOACETIC ACID; ION TRANSPORT AFFECTING AGENT; NAPROXEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG BRAIN LEVEL; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OSTEOARTHRITIS; RAT; SEDATION; STRUCTURE ACTIVITY RELATION;

ACID-SENSING; ASIC-3; DEGENERIN; ION CHANNEL; PAIN;

ACID SENSING ION CHANNEL BLOCKERS; ACID SENSING ION CHANNELS; ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; ELECTROPHYSIOLOGICAL PHENOMENA; FREUND'S ADJUVANT; IODOACETATES; ISOQUINOLINES; MALE; MICE; NAPHTHALENES; NEURONS; OSTEOARTHRITIS; PAIN; PAIN MEASUREMENT; PHYSICAL STIMULATION; POSTURAL BALANCE; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS; RATTUS;

EID: 77952228354     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn9000186     Document Type: Article

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