Contribution of Nitric oxide synthase (NOS) activity in blood- brain barrier disruption and edema after acute ischemia/ reperfusion in aortic coarctation-induced hypertensive rats

Iranian Biomedical Journal

Volumn 15, Issue 1-2, 2011, Pages 22-30

  Mohammadi, Mohammad Taghi ^a   Moosavi, Seyed Mostafa Shid ^a   Dehghani, Gholam Abbas ^a  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acute hypertension; Blood brain barrier (BBB); Ischemia reperfusion injury; L NAME; Nitric oxide synthase (NOX)

Indexed keywords

N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CAROTID ARTERY; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE COURSE; ENZYME INACTIVATION; ENZYME INHIBITION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; INTRACRANIAL HYPERTENSION; LASER DOPPLER FLOWMETRY; MALE; MEMBRANE PERMEABILITY; NONHUMAN; PATHOGENESIS; PRESSURE MEASUREMENT; RAT;

ANIMALS; AORTIC COARCTATION; BLOOD PRESSURE; BLOOD-BRAIN BARRIER; BRAIN EDEMA; CEREBRAL INFARCTION; CEREBROVASCULAR CIRCULATION; HYPERTENSION; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

RATTUS;

EID: 79959860543     PISSN: 1028852X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Chamorro, A., Vila, N., Ascaso, C., Elices, E., Schonewille, W. and Blanc, R. (1998) Blood pressure and functional recovery in acute ischemic stroke. Stroke 29: 1850-1853.
2. Euser, A.G. and Cipolla, M.J. (2007) Cerebral blood flow autoregulation and edema formation during pregnancy in anesthetized rats. Hypertension 49: 334-340.
3. Unterberg, A. W., Stover, J., Kress, B. and Kiening, K. L. (2004) Edema and brain trauma. Neuroscience. 129: 1021-1029.
4. Fagan, S.C., Hess, D.C., Hohnadel, E.J., Pollock, D.M. and Ergul, A. (2004) Targets for vascular protection after acute ischemic stroke. Stroke 35: 2220-2225.
5. Mayhan, W. G. (2001) Regulation of blood-brain barrier permeability. Microcirculation 8: 89-104.
6. Sercombe, R., Issertial, O., Seylaz, J. and Pinard, E. (2001) Effects of chronic L-NAME treatment on rat focal cerebral ischemia and cerebral vasoreactivity. Life Sci. 69: 2203-2216.
7. Parathath, S.R., Parathath, S. and Tsirka, S.E. (2006) Nitric oxide mediates neurodegeneration and breakdown of the blood-brain barrier in tPAdependent excitotoxic injury in mice. J. Cell Sci. 119: 339-349.
8. Han, F., Shirasaki, Y. and Fukunaga, K. (2006) Microsphere embolism-induced endothelial nitric oxide synthase expression mediates disruption of the blood-brain barrier in rat brain. J. Neurochem. 99: 97-106.
9. Ding-Zhou, L., Marchand-Verrecchia, C., Croci, N., Plotkine, M. and Margaill, I. (2002) L-NAME reduces infarction, neurological deficit and bloodbrain barrier disruption following cerebral ischemia in mice. Eur. J. Pharmacol. 457: 137-146.
10. Margaill, I., Allix, M., Boulu, R.G. and Plotkine, M. (1997) Dose-and time-dependence of L-NAME neuroprotection in transient focal cerebral ischaemia in rats. Br. J. Pharmacol. 120: 160-163.
11. Gursoy-Ozdemir, Y., Bolay, H., Saribas, O. and Dalkara, T. (2000) Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia. Stroke 31: 1974-1980.
12. Barton, C.H., Ni, Z. and Vaziri, N.D. (2001) Effect of severe aortic banding above the renal arteries on nitric oxide synthase isotype expression. Kidney Int. 59: 654-661.
13. Lecrux, C., Nicole, O., Chazalviel, L., Catone, C., Chuquet, J., MacKenzie, E.T. and Touzani, O. (2007) Spontaneously hypertensive rats are highly vulnerable to AMPA-induced brain lesions. Stroke 38: 3007-3015.
14. Huang, Z., Huang, P.L., Panahian, N., Dalkara, T., Fishman, M.C. and Moskowitz, M.A. (1994) Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265:1883-1885.
15. Panahpour, H. and Dehghani, G.A. (2010) Inhibition of central angiotensin-converting enzyme with enalapril protects the brain from ischemia/reperfusion injury in normotensive rat. Daru 18: 35-40.
16. Longa, E.Z., Weinstein, P.R., Carlson, S. and Cummins, R. (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20: 84-91.
17. Vakili, A., Nekooeian, A.A. and Dehghani, G.A. (2004) L-NAME and 7-Nitroindazole reduces brain injuries in transient focal cerebral ischemia in the rat. Iran J. Med. Sci. 29: 109-115.
18. Swanson, R.A., Morton, M.T., Tsao-Wu, G., Savalos, R.A., Davidson, C. and Sharp, F.R. (1990) A semiautomated method for measuring brain infarct volume. J. Cereb. Blood Flow Metab. 10: 290-293.
19. Gerriets, T., Stolz, E., Walberer, M., Muller, C., Kluge, A., Bachmann, A., Fisher, M., Kaps, M. and Bachmann, G. (2004) Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging. Stroke. 35: 566-571.
20. Belayev, L., Busto, R., Zhao, W. and Ginsberg, M.D. (1996) Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats. Brain Res. 739: 88-96.
21. Sironi, L., Guerrini, U., Tremoli, E., Miller, I., Gelosa, P., Lascialfari, A., Zucca, I., Eberini, I., Gemeiner, M., Paoletti, R. and Gianazza, E. (2004) Analysis of pathological events at the onset of brain damage in stroke-prone rats: A proteomics and magnetic resonance imaging approach. J. Neurosci. Res. 78: 115-122.
22. Lippoldt, A., Kniesel, U., Liebner, S., Kalbacher, H., Kirsch, T., Wolburg, H. and Haller, H. (2000) Structural alterations of tight junctions are associated with loss of polarity in stroke-prone spontaneously hypertensive rat blood-brain barrier endothelial cells. Brain Res. 885: 251-261.
23. Poulet, R., Gentile, M.T., Vecchione, C., Distaso, M., Aretini, A., Fratta, L., Russo, G., Echart, C., Maffei, A., De Simoni, M.G. and Lembo, G. (2006) Acute hypertension induces oxidative stress in brain tissues. J. Cereb. Blood Flow Metab. 26: 253-262.
24. Qadri, F., Arens, T., Schwarz, E.C., Hauser, W., Dendorfer, A. and Dominiak, P. (2003) Brain nitric oxide synthase activity in spontaneously hypertensive rats during the development of hypertension. J. Hypertens. 21: 1687-1694.
25. Gursoy-Ozdemir, Y., Can, A. and Dalkara, T. (2004) Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia. Stroke 35: 1449-1453.
26. Hawkins, B. and Davis, T.P. (2005) The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 57: 173-185.
27. Xu, M., Su, W. and Xu, Q.P. (2010) Aquaporin-4 and traumatic brain edema. Chin J. Traumatol. 13: 103-110.
28. Deb, P., Sharma, S. and Hassan, K. M. (2010) Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis. Pathophysiology 17: 197-218.
29. Nag, S., Picard, P. and Stewart, D.J. (2000) Increased immunolocalization of nitric oxide synthases during blood-brain barrier breakdown and cerebral edema. Acta Neurochir. Suppl. 76: 65-68.