Ceiling culture-derived proliferative adipocytes retain high adipogenic potential suitable for use as a vehicle for gene transduction therapy

American Journal of Physiology - Cell Physiology

Volumn 301, Issue 1, 2011, Pages

  Asada, Sakiyo ^a,b   Kuroda, Masayuki ^a,b   Aoyagi, Yasuyuki ^a,b   Fukaya, Yoshitaka ^b   Tanaka, Shigeaki ^d   Konno, Shunichi ^d   Tanio, Masami ^d   Aso, Masayuki ^d   Satoh, Kaneshige ^b   Okamoto, Yoshitaka ^a   Nakayama, Toshinori ^c   Saito, Yasushi ^d   Bujo, Hideaki ^b  

^a CHIBA UNIVERSITY HOSPITAL   (Japan)

^b Department of Genome Research and Clinical Application ^*  (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d CHIBA UNIVERSITY   (Japan)

Author keywords

Adipogenesis; Adipose tissue derived stem cells; Gene therapy

Indexed keywords

FAT DROPLET; INDOMETACIN; MEMBRANE ANTIGEN;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE DERIVED STEM CELL; ADIPOSE TISSUE; ARTICLE; AUTOTRANSPLANTATION; CEILING CULTURE DERIVED PROLIFERATIVE ADIPOCYTE; CELL LINEAGE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MARKER GENE; MEDICAL RESEARCH; PRIORITY JOURNAL; REGENERATIVE MEDICINE; STEM CELL GENE THERAPY;

ADIPOCYTES; ADIPOGENESIS; ANTIGENS, SURFACE; CELL PROLIFERATION; CELL TRANSPLANTATION; CELLS, CULTURED; GENE EXPRESSION PROFILING; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; MULTIPOTENT STEM CELLS; STROMAL CELLS;

EID: 79959859241     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00080.2011     Document Type: Article

References (15)

1. Aoyagi Y, Kuroda M, Asada S, Bujo H, Tanaka S, Konno S, Tanio M, Ishii I, Aso M, Saito Y. Fibrin glue increases the cell survival and the transduced gene product secretion of the ceiling culture-derived adipocytes transplanted in mice. Exp Mol Med 43: 161-167, 2011.
2. Casteilla L, Cousin B, Planat-Benard V, Laharrague P, Carmona M, Pénicaud L. Virus-based gene transfer approaches and adipose tissue biology. Curr Gene Ther 8: 79-87, 2008.
3. Fiorenza CG, Chou SH, Mantzoros CS. Lipodystrophy: pathophysiology and advances in treatment. Nat Rev Endocrinol 7: 137-150, 2010.
4. Fraser JK, Wulur I, Alfonso Z, Hedrick MH. Fat tissue: an underappreciated source of stem cells for biotechnology. Trends Biotechnol 24: 150-154, 2006.
5. Gomillion CT, Burg KJ. Stem cells and adipose tissue engineering. Biomaterials 27: 6052-6063, 2006.
6. Ito M, Bujo H, Takahashi K, Arai T, Tanaka I, Saito Y. Implantation of primary cultured adipocytes that secrete insulin modifies blood glucose levels in diabetic mice. Diabetologia 48: 1614-1620, 2005.
7. Kubota Y, Unoki H, Bujo H, Rikihisa N, Udagawa A, Yoshimoto S, Ichinose M, Saito Y. Low-dose GH supplementation reduces the TLR2 and TNF-alpha expressions in visceral fat. Biochem Biophys Res Commun 368: 81-87, 2008.
8. Kuroda M, Aoyagi Y, Asada S, Bujo H, Tanaka S, Konno K, Tanio M, Ishii I, Machida K, Matsumoto F, Satoh K, Aso S, Saito Y. Ceiling culture-derived proliferative adipocytes are a possible delivery vehicle for enzyme replacement therapy in lecithin:cholesterol acyltransferase deficiency. Open Gene Ther J 4: 1-10, 2011.
9. Matsumoto T, Kano K, Kondo D, Fukuda N, Iribe Y, Tanaka N, Matsubara Y, Sakuma T, Satomi A, Otaki M, Ryu J, Mugishima H. Mature adipocyte-derived dedifferentiated fat cells exhibit multilineage potential. J Cell Physiol 215: 210-222, 2008.
10. Miyazaki T, Kitagawa Y, Toriyama K, Kobori M, Torii S. Isolation of two human fibroblastic cell populations with multiple but distinct potential of mesenchymal differentiation by ceiling culture of mature fat cells from subcutaneous adipose tissue. Differentiation 73: 69-78, 2005.
11. Schäffler A, Büchler C. Concise review: adipose tissue-derived stromal cells-basic and clinical implications for novel cell-based therapies. Stem Cells 25: 818-827, 2007.
12. Slawik M, Vidal-Puig AJ. Adipose tissue expandability and the metabolicsyndrome. Genes Nutr 2: 41-45, 2007.
13. Sugihara H, Yonemitsu N, Miyabara S, Yun K. Primary cultures of unilocular fat cells: characteristics of growth in vitro and changes in differentiation properties. Differentiation 31: 42-49, 1986.
14. Tran TT, Kahn CR. Transplantation of adipose tissue and stem cells: role in metabolism and disease. Nat Rev Endocrinol 6: 195-213, 2010.
15. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, Benhaim P, Lorenz HP, Hedrick MH. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7: 211-228, 2001.