Application of LC-MS technique in metabolite and metabonomic research of naditional Chinese medicine

Academic Journal of Second Military Medical University

Volumn 32, Issue 6, 2011, Pages 658-662

  Zhang, Bin ^a   Lou, Zi Yang ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Chinese herbal drugs; Liquidchromatography mass spectrometry; Metabcdites; Metabonomics

Indexed keywords

CHINESE DRUG; DRUG METABOLITE;

CHINESE MEDICINE; COMPARATIVE EFFECTIVENESS; DRUG METABOLISM; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEDLINE; REVIEW; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 79959821659     PISSN: 0258879X     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1008.2011.00658     Document Type: Review

References (45)

1. Nicholson JK, Connelly J, Lindon JC, Holmes E. Metabonomics a platform for studying drug toxicity and gene of function [J]. Nat Rev Drug Discov, 2002, 1:153-161.
2. Annu W. Metabolomics in systems biology[J]. Rev Plant Biol, 2003, 54:669-689.
3. Alvarez-Sanchez B, Priego-Capote F, Luque de Castro M. Metabolomics analysis I.Selection of biological samples and practical aspects preceding sample preparation[J]. Trends Anal Chem, 2010, 29:111-119.
4. Chinese source 2008, 6: 81.
5. Chinese source, 2009, 25:424-428.
6. Lindon J, Nicholson J, Holmes E. Metabonomics metabolic processes studied by NMR spectroscopy of biofluids[J]. Concept Magnetic Res, 2000, 12: 289-320.
7. Chinese source, 2007, 27: 807-809.
8. Londry F, Wells G, March R. Enhanced mass resolution in a quadrupole ion trap[J]. Rapid Commun Mass Spectrom, 1993, 7:43-45.
9. Plumb R, Stumpf C, Granger J. Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids[J]. Rapid Commun Mass Spectrom, 2003, 17: 2632-2638.
10. W B, Elli D. Metabolomics: current analytical patforms and methodol[J]. Trends Anal Chem, 2005, 24:285-294.
11. Chinese source, 2009, 31:106-112.
12. Jin H, Kumar A, Paik D, Ha K, Yoo Y, Lee Y. Trace analysis of tetracycline antibiotics in human urine using UPLC-QToF mass spectrometry[J]. Microchem J, 2010, 94:139-147.
13. Nordstrolm A, Maille G, Qin C. Nonlinear data alignment for UPLC-MS and HPLC-MS based metabolomics: quantitative analysis of endogenous and exogenous metabolites in human serum[J]. Anal Chem, 2006, 78:3289-3295.
14. Chinese source, 2009, 7:394-399.
15. Tyler A, Clayton E, Green B. Exact mass measurement of polar organic molecules at low resolution using electrosp ray ionization and a quadrupole mass spectrometer[J]. Anal Chem, 1996, 68:3561-3569.
16. Bobeldijk I, Viessers JP, Kearney G. Screening and identification of unknown contaminants in water with liquid chromatography and quadrupole-orthogonal acceleration-time of-flight tandem massspectrometry[J]. J Chromatogr A, 2001, 929:63-74.
17. Thurman E, Ferrer I, Zweigenbaum J. Discovering metabolites of post harvest funguicides in citrus with liquid chromatography/time-of-flight mass spectrometry and ion trap mass spectrometry[J]. J Chromatogr A, 2005, 1082:71-80.
18. Ferrer I, Thurman E. Multi-residue method for the analysis of 101 pesticides and their degradates in food and water samples by liquid chromatography/time-of-flight[J]. Mass Spectrom, 2007, 1175:24-37.
19. Lacorte S, Fernandez-Alba A. Time of flight mass spectrometry applied to the liquid chromatographic analysis of pesticides in water and food[J]. Mass Spec Rev, 2006, 25:866-880.
20. Ari T, Miia T, Olavi P. Liquid chromatography mass spectrometry in in vitro drug metabolite screening[J]. Drug Discovery Today, 2009, 14:120-133.
21. Li Q, Su S. Application of systems biology in traditional Chinese medicine research[J]. Mode Tradit Chin Med Mater Med, 2008, 10:1-6.
22. Chen H, Chen Y, Wang H, Du P, Han F, Zhang H. Analysis of scopolamine and its eighteen metabolites in rat urine by liquid chromatography-tandem mass spectrometry[J]. Talanta, 2005, 67:984-991.
23. Zhang W, Saif M, Dutschman G, Li X, Lam W, Bussom S, et al. Identification of chemicals and their metabolites from PHY906, a Chinese medicine formulation, in the plasma of a patient treated with irinotecan and PHY906 using liquid chromatography/tandem mass spectrometry(LC/MS/MS)[J]. J Chromatogr A, 2010, 1217:5785-5793.
24. Ma C, Bi K, Zhang M, Su D, Fan X, Ji W, et al. Toxicology effects of morning glory seed in rat: a metabonomic method for profiling of urine metabolic changes[J]. J Ethnophamacol, 2010, 130: 134-142.
25. Zhao X, Zhang Y, Meng X, Yin P, Deng C, Chen J, et al. Effect of a traditional Chinese medicine preparation Xindi soft capsule on rat model of a cute blood stasis: a urinary metabonomics study based on liquid chromatography mass spectrometry[J]. J Chromatogr B, 2008, 873:151-158.
26. Wang P, Sun H, Lv H, Sun W, Yuan Y, Han Y, et al. Thyroxine and reserpine-induced changes in metabolic profiles of rat urine and the therapeutic effect of Liu Wei Di Huang Wan detected by UPLC-HDMS[J]. J Pharm Biomed Anal, 2010, 53:631-645.
27. Sun J, Yang M, Wang X, Xu M, Liu A, Guo D. Identification of tanshinones and their metabolites in rat bile after oral adminis-tration of TTE-50, a standardized extract of Salvia miltiorrhiza by HPLC-ESI-DAD-MSn[J]. J Pharm Biomed Anal, 2007, 44: 564-574.
28. Su S, Guo J, Duan J, Wang T, Qian D, Shang E, et al. Ultra-performance liquid chromatography tandem mass spectrometry analysis of the bioactive components and their metabolites of Shaofu Zhuyu decoction active extract in rat plasma[J]. J Chromatogr B, 2010, 878:355-362.
29. Ni S, Qian D, Duan J, Guo J, Shang E, Shu Y, et al. UPLC-QT-OF/MS-based screening and identification of the constituents and their metabolites in rat plasma and urine after oral administration of Glechoma longituba extract[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2010, 878:2741-2750.
30. Li S, Lai S, Song J, Qiao C, Liu X, Zhou Y, et al. Decocting-in-duced chemical transformations and global quality of Du Shen Tang, the decoction of ginseng evaluated by UPLCQ-TOF-MS/MS based chemical profiling approach[J]. J Pharma Biomed Anal, 2010, 53:946-957.
31. Dai H, Wang M, Li X, Wang L, Li Y, Xue M. Structural elucidation of in vitro and invivo metabolites of cryptotanshinone by HPLC-DAD-ESI-MSn[J]. J Pharma Biomed Anal, 2008, 48: 885-896.
32. Prasain J, Peng N, Moore R, Arabshahi A, Barnes S, Wyss J. Tissue distribution of puerarin and its conjugated metabolites in rats assessed by liquid chromatography tandem mass spectrometry[J]. Phytomedicine, 2009, 16:65-71.
33. Xu M, Guo H, Han J, Sun S, Liu A, Wang B, et al. Structural characterization of metabolites of salvianolic acid B from Salvia miltiorrhiza in normal and antibiotic-treated rats by liquid chromatography mass spectrometry[J]. Chromatogr B, 2007, 858:184-198.
34. Zhang Z, Xu M, Sun S, Qiao X, Wang B, Han J, et al. Metabolic analysis of four phenolic acids in rat by liquid chromatography tandem mass spectrometry[J]. J Chromatogr B, 2008, 871:7-14.
35. Chinese source, 2005, 40:740-745.
36. Chinese source, 2005, 40:838-841.
37. Chen Y, Song W, Peng ZH, GeB Y, Han FM. Identification of metabolites of tectoridin in-vivo and in-vitro by liquid chroma-tography-tandem mass spectrometry[J]. J Pharm Pharmacol, 2008, 60:709-716.
38. Ding W, Deng Y, Feng H, Liu W, Hu R, Li X, et al. Biotransformation of aesculin by human gut bacteria and identification of its metabolites in rat urine[J]. World J Gastroenterol, 2009, 15: 1518-1523.
39. Feng NP, Di B, Liu WY. Comparison of the metabolism of baicalin in rats orally administered with Radix scutellari[J]. Chem Pharm Bull(Tokyo), 2005, 53:978-983.
40. Sekiya K, Tezuka Y, Tanaka K, Prasain JK, Namba T, Katayama K, et al. Distribution, metabolism and excretion of butylidenephthalide of Ligustici chuanxiong rhizoma in hairless mouse after dermal application[J]. J Ethnopharmacol, 2000, 71:401-409.
41. Tianniam S, Bamba T, Fukusaki E. Non-targeted metabolite fingerprintg of oriental folk medicine Angelicaacutiloba roots by ultra performance liquid chromatography time-of-flight mass spectrometry[J]. J Sep Sci, 2009, 32:2233-2244.
42. Yan S, Wu B, Lin Z, Jin H, Huang J, Yang Y, et al. Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium[J]. Mol Biosyst, 2009, 5: 1204-1213.
43. Zhu M, Han F, Chen H, Peng Z, Chen Y. Identification of palmatine and its metabolites in rat urine by liquid chromatography/tandem mass spectrometry[J]. Rapid Commun Mass Spectrom, 2007, 21:2019-2022.
44. Zhou T, Liu H, Wen J, Fan G, Chai Y, Wu Y. Fragmentation study of iridoid glycosides including epimers by liquid chromatography-diode array detection/electrospray ionization mass spectrometry and its application in metabolic fingerprint analysis of Gardenia jasminoides Ellis[J]. Rapid Commun Mass Spectrom, 2010, 24:2520-2528.
45. William J, Therese K, Wang Y, Matthias K, David P. Targeted metabolomics for biomarker discovery[J]. Angew Chem Int Ed, 2010, 49: 5426-5445.