Proteomic and functional analyses reveal the potential involvement of endoplasmic reticulum stress and α-CP1 in the anticancer activities of oridonin in HepG2 cells

Integrative Cancer Therapies

Volumn 10, Issue 2, 2011, Pages 160-167

  Wang, Hui ^a   Ye, Yan ^a   Chu, Jian Hong ^a   Zhu, Guo Yuan ^a   Fong, Wang Fun ^a   Yu, Zhi Ling ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

CP1; apoptosis; ER stress; Grp78; oridonin; proteomics

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACTIVATING TRANSCRIPTION FACTOR 1; ACTIVATING TRANSCRIPTION FACTOR 6; ALPHA CP1 PROTEIN; FLUORESCEIN ISOTHIOCYANATE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; ORIDONIN; PERK PROTEIN; PROTEIN; PROTEIN IRE1; RIBONUCLEOPROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL ASSAY; CELL DEATH; CELL GROWTH; CELL NUCLEUS; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; FUNCTIONAL PROTEOMICS; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 6; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CELL SURVIVAL; DITERPENES, KAURANE; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; GENE EXPRESSION; HEAT-SHOCK PROTEINS; HEP G2 CELLS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; LIVER NEOPLASMS; MEMBRANE PROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEOMICS; RNA, SMALL INTERFERING; TRANSCRIPTION FACTOR CHOP;

EID: 79959810572     PISSN: 15347354     EISSN: 1552695X     Source Type: Journal    
DOI: 10.1177/1534735410383171     Document Type: Article

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