Medical treatment of acquired nystagmus

Expert Review of Ophthalmology

Volumn 6, Issue 3, 2011, Pages 307-314

  Thurtell, Matthew J ^a,b   Rucker, Janet C ^c   Tomsak, Robert L ^d   Leigh, R John ^e  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c MOUNT SINAI MEDICAL CENTER   (United States)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

acetazolamide; aminopyridines; baclofen; gabapentin; memantine; multiple sclerosis; nystagmus; oculopalatal tremor; oscillopsia

Indexed keywords

3,4 DIAMINOPYRIDINE; 4 AMINOPYRIDINE; ACETAZOLAMIDE; BACLOFEN; CLONAZEPAM; GABAPENTIN; MEMANTINE; SCOPOLAMINE; TRIHEXYPHENIDYL;

ACQUIRED PENDULAR NYSTAGMUS; ARTICLE; BLURRED VISION; COORDINATION DISORDER; DIZZINESS; DROWSINESS; DRUG MECHANISM; DRUG RESPONSE; EPILEPSY; EYE MOVEMENT DISORDER; HEADACHE; HEART ARRHYTHMIA; HEREDITARY ATAXIA; HUMAN; LETHARGY; NYSTAGMUS; PARESTHESIA; PERIODIC ALTERNATING NYSTAGMUS; SEASAW NYSTAGMUS; TASTE DISORDER; TORSIONAL NYSTAGMUS; TREATMENT OUTCOME; VESTIBULAR NYSTAGMUS; XEROSTOMIA;

EID: 79959804783     PISSN: 17469899     EISSN: 17469902     Source Type: Journal    
DOI: 10.1586/eop.11.22     Document Type: Article

References (58)

1. Leigh RJ, Zee DS. The Neurology of Eye Movements (4th EditionOxford University Press, NY, USA (2006
2. Thurtell MJ, Leigh RJ. Therapy for nystagmus. J. Neuroophthalmol. 30(4), 361-371 (2010
3. Sarvananthan N, Surendran M, Roberts EO et al. The prevalence of nystagmus: the Leicestershire nystagmus survey. Invest. Ophthalmol. Vis. Sci. 50(11), 5201-5206 (2009
4. Thurtell MJ, Leigh RJ. Nystagmus and saccadic intrusions. In: Handbook of Clinical Neurology: Neuro-Ophthalmology. Leigh RJ, Kennard C (EdsElsevier, Amsterdam, The Netherlands, 331-376 (2011
5. Zee DS. Suppression of vestibular nystagmus. Ann. Neurol. 1(2), 207 (1977
6. Huppert D, Strupp M, Mückter H, Brandt T. Which medication do I need to manage dizzy patients? Acta Otolaryngol. 131(3), 228-241 (2010
7. Halmagyi GM, Thurtell MJ, Curthoys IS. Vertigo - clinical syndromes. In: Scott-Brown's Otorhinolaryngology, Head and Neck Surgery (7th EditionGleeson MJ (Ed.Hodder-Arnold, London, UK, 3748-3790 (2008
8. Wagner JN, Glaser M, Brandt T, Strupp M. Downbeat nystagmus: aetiology and comorbidity in 117 patients. J. Neurol. Neurosurg. Psychiatry 79(6), 672-677 (2008 (Pubitemid 351829440)
9. Currie JN, Matsuo V. The use of clonazepam in the treatment of nystagmus-induced oscillopsia. Ophthalmology 93(7), 924-932 (1986 (Pubitemid 16046102)
10. Young YH, Huang TW. Role of clonazepam in the treatment of idiopathic downbeat nystagmus. Laryngoscope 111(8), 1490-1493 (2001
11. Dieterich M, Straube A, Brandt T, Paulus W, Büttner U. The effects of baclofen and cholinergic drugs on upbeat and downbeat nystagmus. J. Neurol. Neurosurg. Psychiatry 54(7), 627-632 (1991
12. Kastrup O, Maschke M, Keidel M, Diener HC. Presumed pharmacologically induced change from upbeat- to downbeat nystagmus in a patient with Wernicke's encephalopathy. Clin. Neurol. Neurosurg. 107(1), 70-72 (2004 (Pubitemid 39556682)
13. Averbuch-Heller L, Tusa RJ, Fuhry L et al. A double-blind controlled study of gabapentin and baclofen as treatment for acquired nystagmus. Ann. Neurol. 41(6), 818-825 (1997 (Pubitemid 27249189)
14. Bauer CS, Nieto-Rostro M, Rahman W et al. The increased trafficking of the calcium channel subunit a2d-1 to presynaptic terminals in neuropathic pain is inhibited by the a2d ligand pregabalin. J. Neurosci. 29(13), 4076-4088 (2009
15. Barton JJ, Huaman AG, Sharpe JA. Muscarinic antagonists in the treatment of acquired pendular and downbeat nystagmus: a double-blind, randomized trial of three intravenous drugs. Ann. Neurol. 35(3), 319-325 (1994 (Pubitemid 24089655)
16. Leigh RJ, Burnstine TH, Ruff RL, Kasmer RJ. The effect of anticholinergic agents upon acquired nystagmus: a double-blind study of trihexyphenidyl and tridihexethyl chloride. Neurology 41(11), 1737-1741 (1991
17. Strupp M, Schuler O, Krafczyk S et al. Treatment of downbeat nystagmus with 3,4-diaminopyridine: a placebo-controlled study. Neurology 61(2), 165-170 (2003 (Pubitemid 36875295)
18. Kalla R, Glasauer S, Schautzer F et al. 4-aminopyridine improves downbeat nystagmus, smooth pursuit, and VOR gain. Neurology 62(7), 1228-1229 (2004 (Pubitemid 38456530)
19. Glasauer S, Rossert C. Modelling drug modulation of nystagmus. Prog. Brain Res. 171, 527-534 (2008
20. Helmchen C, Sprenger A, Rambold H, Sander T, Kompf D, Straumann D. Effect of 3,4-diaminopyridine on the gravity dependence of ocular drift in downbeat nystagmus. Neurology 63(4), 752-753 (2004 (Pubitemid 39100846)
21. Thurtell MJ, Tomsak RL, Leigh RJ. Upbeat-torsional nystagmus and contralateral fourth nerve palsy due to unilateral dorsal ponto-mesencephalic lesion. Ann. NY Acad. Sci. 1164, 476-478 (2009
22. Thurtell MJ, Joshi AC, Leone AC et al. Crossover trial of gabapentin and memantine as treatment for acquired nystagmus. Ann. Neurol. 67(5), 676-680 (2010
23. Glasauer S, Kalla R, Buttner U, Strupp M, Brandt T. 4-aminopyridine restores visual ocular motor function in upbeat nystagmus. J. Neurol. Neurosurg. Psychiatry 76(3), 451-453 (2005 (Pubitemid 40299147)
24. Halmagyi GM, Rudge P, Gresty MA, Leigh RJ, Zee DS. Treatment of periodic alternating nystagmus. Ann. Neurol. 8(6), 609-611 (1980 (Pubitemid 11213506)
25. Furman JM, Wall C III, Pang D. Vestibular function in periodic alternating nystagmus. Brain 113(5), 1425-1439 (1990 (Pubitemid 20385922)
26. Garbutt S, Thakore N, Rucker JC, Han Y, Kumar AN, Leigh RJ. Effects of visual fixation and convergence in periodic alternating nystagmus due to MS. Neuroophthalmology 28, 221-229 (2004 (Pubitemid 40110534)
27. Cohen B, Dai M, Yakushin SB, Raphan T. Baclofen, motion sickness susceptibility and the neural basis for velocity storage. Prog. Brain Res. 171, 543-553 (2008
28. Kumar A, Thomas S, McLean R et al. Treatment of acquired periodic alternating nystagmus with memantine: a case report. Clin. Neuropharmacol. 32(2), 109-110 (2009
29. Barton JJ, Cox TA. Acquired pendular nystagmus in multiple sclerosis: clinical observations and the role of optic neuropathy. J. Neurol. Neurosurg. Psychiatry 56(3), 262-267 (1993 (Pubitemid 23101206)
30. Averbuch-Heller L, Zivotofsky AZ, Das VE, DiScenna AO, Leigh RJ. Investigations of the pathogenesis of acquired pendular nystagmus. Brain 118(2), 369-378 (1995
31. Das VE, Oruganti P, Kramer PD, Leigh RJ. Experimental tests of a neural-network model for ocular oscillations caused by disease of central myelin. Exp. Brain Res. 133(2), 189-197 (2000 (Pubitemid 30449904)
32. Arnold DB, Robinson DA, Leigh RJ. Nystagmus induced by pharmacological inactivation of the brainstem ocular motor integrator in monkey. Vision Res. 39(25), 4286-4295 (1999 (Pubitemid 29490945)
33. Straube A, Kurzan R, Büttner U. Differential effects of bicuculline and muscimol microinjections into the vestibular nuclei on simian eye movements. Exp. Brain Res. 86(2), 347-358 (1991
34. Lefkowitz D, Harpold G. Treatment of ocular myoclonus with valproic acid. Ann. Neurol. 17(1), 103-104 (1985
35. Traccis S, Rosati G, Monaco MF, Aiello I, Agnetti V. Successful treatment of acquired pendular elliptical nystagmus in multiple sclerosis with isoniazid and base-out prisms. Neurology 40(3), 492-494 (1990 (Pubitemid 20117536)
36. Bandini F, Castello E, Mazzella L, Mancardi GL, Solaro C. Gabapentin but not vigabatrin is effective in the treatment of acquired nystagmus in multiple sclerosis: how valid is the GABAergic hypothesis? J. Neurol. Neurosurg. Psychiatry 71(1), 107-110 (2001
37. Starck M, Albrecht H, Pöllmann W, Dieterich M, Straube A. Acquired pendular nystagmus in multiple sclerosis: an examiner-blind cross-over treatment study of memantine and gabapentin. J. Neurol. 257(3), 322-327 (2010
38. Starck M, Albrecht H, Straube A, Dieterich M. Drug therapy for acquired pendular nystagmus in multiple sclerosis. J. Neurol. 244(1), 9-16 (1997 (Pubitemid 26413892)
39. Shery T, Proudlock FA, Sarvananthan N, McLean RJ, Gottlob I. The effects of gabapentin and memantine in acquired and congenital nystagmus: a retrospective study. Br. J. Ophthalmol. 90(7), 839-843 (2006 (Pubitemid 43973992)
40. Villoslada P, Arrondo G, Sepulcre J, Alegre M, Artieda J. Memantine induces reversible neurologic impairment in patients with MS. Neurology 72(19), 1630-1633 (2009
41. Ruigrok TJ, de Zeeuw CI, Voogd J. Hypertrophy of inferior olivary neurons: a degenerative, regenerative or plasticity phenomenon. Eur. J. Morphol. 28(2-4), 224-239 (1990 (Pubitemid 20333242)
42. Shaikh AG, Hong S, Liao K et al. Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticity. Brain 133(3), 923-940 (2010
43. Kim JS, Moon SY, Choi KD, Kim JH, Sharpe JA. Patterns of ocular oscillation in oculopalatal tremor: imaging correlations. Neurology 68(14), 1128-1135 (2007 (Pubitemid 46559847)
44. Herishanu Y, Louzoun Z. Trihexyphenidyl treatment of vertical pendular nystagmus. Neurology 36(1), 82-84 (1986 (Pubitemid 16186055)
45. Jabbari B, Rosenberg M, Scherokman B, Gunderson CH, McBurney JW, McClintock W. Effectiveness of trihexyphenidyl against pendular nystagmus and palatal myoclonus: evidence of cholinergic dysfunction. Mov. Disord. 2(2), 93-98 (1987
46. Kim JI, Averbuch-Heller L, Leigh RJ. Evaluation of transdermal scopolamine as treatment for acquired nystagmus. J. Neuroophthalmol. 21(3), 188-192 (2001 (Pubitemid 33028980)
47. Griggs RC, Moxley R, Lafrance R, McQuillen J. Hereditary paroxysmal ataxia: response to acetazolamide. Neurology 28(12), 1259-1264 (1978 (Pubitemid 9030411)
48. Marti S, Baloh RW, Jen JC, Straumann D, Jung HH. Progressive cerebellar ataxia with variable episodic symptoms: phenotypic diversity of R1668W CACNA1A mutation. Eur. Neurol. 60(1), 16-20 (2008 (Pubitemid 351799062)
49. Strupp M, Kalla R, Dichgans M, Freilinger T, Glasauer S, Brandt T. Treatment of episodic ataxia Type 2 with the potassium channel blocker 4-aminopyridine. Neurology 62(9), 1623-1625 (2004 (Pubitemid 38608211)
50. Frisén L, Wikkelso C. Posttraumatic seesaw nystagmus abolished by ethanol ingestion. Neurology 36(6), 841-844 (1986 (Pubitemid 16056228)
51. Lepore FE. Ethanol-induced reduction of pathological nystagmus. Neurology 37(5), 887 (1987
52. Cochin JP, Hannequin D, Domarcolino C, Didier T, Augustin P. Intermittent see-saw nystagmus abolished by clonazepam. Rev. Neurol. (Paris) 151(1), 60-62 (1995
53. Halmagyi GM, Aw ST, Dehaene I, Curthoys IS, Todd MJ. Jerk-waveform see-saw nystagmus due to unilateral meso-diencephalic lesion. Brain 117(4), 789-803 (1994 (Pubitemid 24281841)
54. Das VE, Leigh RJ, Swann M, Thurtell MJ. Muscimol inactivation caudal to the interstitial nucleus of Cajal induces hemi-seesaw nystagmus. Exp. Brain Res. 205(3), 405-413 (2010
55. Condorelli DF, Parenti R, Spinella F et al. Cloning of a new gap junction gene (CX36) highly expressed in mammalian brain neurons. Eur. J. Neurosci. 10(3), 1202-1208 (1998 (Pubitemid 28375646)
56. Devor A, Yarom Y. Electrotonic coupling in the inferior olivary nucleus revealed by simultaneous double patch recordings. J. Neurophysiol. 87(6), 3048-3058 (2002 (Pubitemid 34670684)
57. Cruikshank SJ, Hopperstad M, Younger M, Connors BW, Spray DC. Potent block of Cx36 and Cx50 gap junction channels by mefloquine. Proc. Natl Acad. Sci. USA 101(33), 12364-12369 (2004 (Pubitemid 39145449)
58. Wang ZI, Dell'Osso LF, Tomsak RL, Jacobs JB. Combining recessions (nystagmus and strabismus) with tenotomy improved visual function and decreased oscillopsia and diplopia in acquired downbeat nystagmus and in horizontal infantile nystagmus syndrome. J. AAPOS 11(2), 135-141 (2007). (Pubitemid 46528789)