Treatment of downbeat nystagmus with 3,4-diaminopyridine: A placebo-controlled study

Neurology

Volumn 61, Issue 2, 2003, Pages 165-170

  Strupp, M ^a   Schuler O ^b   Krafczyk, S ^b   Jahn, K ^b   Schautzer, F ^b   Buttner U ^b   Brandt, T ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIAMINOPYRIDINE;

ADULT; AGED; ARNOLD CHIARI MALFORMATION; ARTICLE; BRAIN INFARCTION; CEREBELLUM ATROPHY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EPILEPSY; FEMALE; HUMAN; MALE; NAUSEA; NYSTAGMUS; OSCILLOPSIA; PARESTHESIA; PRIORITY JOURNAL; PURKINJE CELL; RANDOMIZED CONTROLLED TRIAL; SEIZURE; SIDE EFFECT; STANDING; TREATMENT OUTCOME; WALKING;

EID: 0038119445     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000078893.41040.56     Document Type: Article

References (20)

1. Dieterich M, Straube A, Brandt T, Paulus W, Büttner U. The effects of baclofen and cholinergic drugs on upbeat and downbeat nystagmus. J Neurol Neurosurg Psychiatry 1991;54:627-632.
2. Averbuch-Heller L, Tusa RJ, Fuhry L, et al. A double-blind controlled study of gabapentin and baclofen as treatment for acquired nystagmus. Ann Neurol 1997;41:818-825.
3. Chambers BR, Ell JJ, Gresty MA. Case of downbeat nystagmus influenced by otolith stimulation. Ann Neurol 1983;13:204-207.
4. Currie JN, Matsuo V. The use of clonazepam in the treatment of nystagmus-induced oscillopsia. Ophthalmology 1986;93:924-932.
5. Barton JJ, Huaman AG, Sharpe JA. Muscarinic antagonists in the treatment of acquired pendular and downbeat nystagmus: a double-blind, randomized trial of three intravenous drugs. Ann Neurol 1994;35:319-325.
6. Leigh RJ, Burnstine TH, Ruff RL, Kasmer RJ. Effect of anticholinergic agents upon acquired nystagmus: a double blind-study of trihexyphenidyl and tridehexethyl chloride, Neurology 1991;41:1737-1741.
7. Büttner U, Fuhry L. Drug therapy of nystagmus and saccadic intrusions, In: Büttner U, ed. Vestibular dysfunction and its therapy. Basel: Karger, 1999:195-227.
8. Leigh RJ, Zee DS. The neurology of eye movements. 3rd ed. Philadelphia: Davis, 1999.
9. Hille B. Ionic channels of excitable membranes. 3rd ed. Sunderland, MA: Sinauer Associates, 1999.
10. Bever C-TJ, Anderson PA, Leslie J, et al. Treatment with oral 3,4-diaminopyridine improves leg strength in multiple sclerosis patients: results of a randomized, double-blind, placebo-controlled, crossover trial. Neurology 1996;47:1457-1462.
11. Sanders DB, Massey JM, Sanders LL, Edwards LJ. A randomized trial of 3,4-diaminopyridine in Lambert-Eaton myasthenic syndrome. Neurology 2000;54:603-607.
12. Etzion Y, Grossman Y. Highly 4-aminopyridine sensitive delayed rectifier current modulates the excitability of guinea pig cerebellar Purkinje cells. Exp Brain Res 2001;139:419-425.
13. Pereira CB, Strupp M, Eggert T, Straube A, Brandt T. Nicotine-induced nystagmus: three-dimensional analysis and dependence on head position. Neurology 2000;55:1563-1566.
14. Baloh RW, Spooner JW. Downbeat nystagmus: a type of central vestibular nystagmus. Neurology 1981;31:304-310.
15. Böhmer A, Straumann D. Pathomechanism of mammalian downbeat nystagmus due to cerebellar lesion: a simple hypothesis. Neurosci Lett 1998;250:127-130.
16. Ito M, Nisimaru N, Yamamoto M. Specific patterns of neuronal connections involved in the control of the rabbit's vestibulo-ocular reflexes by the cerebellar flocculus. J Physiol (Lond) 1977;265:833-854.
17. Zee DS, Yamazaki N, Butler PHZ, Bücer F. Effects of ablation of flocculus and paraflocculus on eye movements in primate. J Neurophysiol 1981;46:878-899.
18. Marti S, Palla A, Straumann D. Gravity dependence of ocular drift in patients with cerebellar downbeat nystagmus. Ann Neurol 2002;52:712-721.
19. Glasauer S, Hoshi M, Kempermann U, Eggert T, Büttner U. Three-dimensional eye position and slow phase velocity in humans with downbeat nystagmus. J Neurophysiol 2003;89:338-354.
20. Martindale. Martindale - the extra pharmacopoeia. 30th ed. London: Pharmaceutical Press, 2000.