Nystagmus induced by pharmacological inactivation of the brainstem ocular motor integrator in monkey

Vision Research

Volumn 39, Issue 25, 1999, Pages 4286-4295

  Arnold, Donald B ^a   Robinson, David A ^a   Leigh, R John ^b,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Univ H   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Cerebellum; GABA; Neural integrator; NMDA; Nystagmus

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; 6,7 DINITRO 2,3 QUINOXALINEDIONE; GLUTAMATE RECEPTOR; GLYCINE; KAINIC ACID; KAINIC ACID RECEPTOR; MUSCIMOL; N METHYL DEXTRO ASPARTIC ACID; STRYCHNINE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN STEM; CONTROLLED STUDY; EYE MOVEMENT; GAZE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MONKEY; NEUROTRANSMISSION; NONHUMAN; NYSTAGMUS; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT;

NON-PROGRAMMATIC;

ANIMALS; BRAIN STEM; EYE MOVEMENTS; GABA AGONISTS; GABA ANTAGONISTS; GLYCINE; MACACA MULATTA; NEUROTRANSMITTER AGENTS; NYSTAGMUS, PATHOLOGIC; RECEPTORS, KAINIC ACID; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0032870184     PISSN: 00426989     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0042-6989(99)00142-X     Document Type: Article

References (28)

1. Abel L.A., Dell'Osso L.F., Daroff R.B. Analog model for gaze-evoked nystagmus. IEEE Transactions on Biomedical Engineering. 25:1978;71-75.
2. Arnold D.B., Robinson D.A. The oculomotor integrator: testing of a neural network model. Experimental Brain Research. 113:1997;57-74.
3. Averbuch-Heller L., Tusa R.J., Fuhry L., Rottach K.G., Ganser G.L., Heide W., Büttner U., Leigh R.J. A double-blind controlled study of gabapentin and baclofen as treatment for acquired nystagmus. Annals of Neurology. 41:1997;818-825.
4. Barton J.J.S., Sharpe J.A. Oscillopsia and horizontal nystagmus with accelerating slow phases following lumbar puncture in the Arnold-Chiari malformation. Annals of Neurology. 33:1993;418-421.
5. Büttner-Ennever J.A. Patterns of connectivity in the vestibular nuclei. Annals of the New York Academy of Science. 656:1992;363-378.
6. Carpenter R.H.S. Cerebellectomy and the transfer function of the vestibulo-ocular reflex in the decerebrate cat. Proceeding of the Royal Society (London) Series B. 181:1972;353-374.
7. Carpenter R.H.S. The visual origins of ocular motility. Cronly-Dillon J.R. Vision and visual function. Eye movements. 8:1991;1-10 MacMillan Press, London.
8. Cannon S.C., Robinson D.A. Loss of the neural integrator of the oculomotor system from brain stem lesions in monkey. Journal of Neurophysiology. 57:1987;1383-1409.
9. Cheron G., Godaux E. Disabling of the oculomotor neural integrator by kainic acid injections in the prepositus-vestibular complex of the cat. Journal of Physiology (London). 394:1987;267-290.
10. Fuchs A.F., Scudder C.A., Kaneko C.R.S. Discharge patterns and recruitment order of identified motoneurons and internuclear neurons in the monkey abducens nucleus. Journal of Neurophysiology. 60:1988;1874-1895.
11. Helmchen C., Rambold H., Fuhry L., Büttner U. Deficits in vertical and torsional eye movements after uni- and bilateral muscimol inactivation of the interstitial nucleus of Cajal of the alert monkey. Experimental Brain Research. 119:1998;436-452.
12. Kamath B.Y., Keller E.L. A neurological integrator for the oculomotor control system. Mathematical Biosciences. 30:1976;341-352.
13. Leigh R.J., Zee D.S. The neurology of eye movements. 3rd ed. 1999;Oxford University Press, New York.
14. McFarland J.L., Fuchs A.F. Discharge patterns in nucleus prepositus hypoglossi and adjacent medial vestibular nucleus during horizontal eye movement in behaving macaques. Journal of Neurophysiology. 68:1992;319-332.
15. Miles F.A., Fuller J. Visual tracking and the primate flocculus. Science. 189:1975;1000-1002.
16. Mettens P., Godaux E., Cheron G., Galiana H.L. Effect of muscimol microinjections into the prepositus hypoglossi and the medial vestibular nuclei on cat eye movements. Journal of Neurophysiology. 72:1994;785-802.
17. Mettens P., Cheron G., Godaux E. NMDA receptors are involved in temporal integration in the oculomotor system of the cat. Neuroreport. 5:1994;1333-1336.
18. Mugnaini, E., & Oertel, W. H. (1985). An atlas of the distribution of GABA-ergic neurons and terminals in the rat CNS as revealed by GAD-immunohistochemistry. In: A. Björklund, & T. Hökfelt, Handbook of chemical anatomy, vol. 4, part 1. GABA and neuropeptides in the CNS (pp. 436-608). Amsterdam: Elsevier.
19. Robinson D.A. A method of measuring eye movement using a scleral search coil in a magnetic field. IEEE Transactions on Biomedical Electronics. 10:1963;137-145.
20. Robinson D.A. The effect of cerebellectomy on the cat's vestibulo-ocular integrator. Brain Research. 71:1974;195-207.
21. Robinson D.A. Oculomotor control signals. Lennerstrand G., Bach-y-Rita P. Basic mechanisms of ocular motility and their clinical implications. 1975;337-374 Pergamon Press, Oxford.
22. Smith O.A., Kastella K.G., Randall D.C. A stereotaxic atlas of the brainstem of macaca mullata in the sitting position. Journal of Comparative Neurology. 29:1972;467-492.
23. Starck M., Albrecht H., Straube A., Dieterich M. Drug therapy for acquired pendular nystagmus in multiple sclerosis. Journal of Neurology. 244:1997;9-16.
24. Straube A., Kurzan R., Büttner U. Differential effects of bicuculline and muscimol microinjections into the vestibular nuclei on simian eye movements. Experimental Brain Research. 86:1991;347-358.
25. Van Gisbergen J.A.M., Robinson D.A., Gielen S. A quantitative analysis of the generation of saccadic eye movements by burst neurons. Journal of Neurophysiology. 45:1981;417-442.
26. Waespe W., Henn V. Neuronal activity in the vestibular nuclei of the alert monkey during vestibular and optokinetic stimulation. Experimental Brain Research. 27:1977;523-538.
27. Zee D.S., Leigh R.J., Mathieu-Millaire F. Cerebellar control of ocular gaze stability. Annals of Neurology. 7:1980;37-40.
28. Zee D.S., Yamazaki A., Butler P.H., Gücer G. Effects of ablation of flocculus and paraflocculus on eye movements in primate. Journal of Neurophysiology. 46:1981;878-899.