Modulation of cortisol responses to the DEX/CRH test by polymorphisms of the interleukin-1beta gene in healthy adults

Behavioral and Brain Functions

Volumn 7, Issue , 2011, Pages

  Sasayama, Daimei ^a,b   Hori, Hiroaki ^a,d   Iijima, Yoshimi ^a,c   Teraishi, Toshiya ^a   Hattori, Kotaro ^a   Ota, Miho ^a   Fujii, Takashi ^a   Higuchi, Teruhiko ^a   Amano, Naoji ^b   Kunugi, Hiroshi ^a,d  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; HYDROCORTISONE; INTERLEUKIN 1; DIAGNOSTIC AGENT; INTERLEUKIN 1BETA;

ADULT; ARTICLE; ENDOCRINE FUNCTION TEST; FEMALE; GENDER; GENE FREQUENCY; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HORMONAL REGULATION; HORMONE RESPONSE; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ALLELE; GENETICS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; METHODOLOGY; MIDDLE AGED; PHYSIOLOGY; SEXUAL DEVELOPMENT;

ADULT; ALLELES; CORTICOTROPIN-RELEASING HORMONE; DEXAMETHASONE; FEMALE; GENOTYPE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INTERLEUKIN-1BETA; MALE; MIDDLE AGED; PITUITARY-ADRENAL FUNCTION TESTS; PITUITARY-ADRENAL SYSTEM; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX CHARACTERISTICS;

EID: 79959804499     PISSN: None     EISSN: 17449081     Source Type: Journal    
DOI: 10.1186/1744-9081-7-23     Document Type: Article

References (59)

1. Owen BM, Eccleston D, Ferrier IN, Young AH. Raised levels of plasma interleukin-1beta in major and postviral depression. Acta Psychiatr Scand 2001, 103:226-228. 10.1034/j.1600-0447.2001.00162.x, 11240580.
2. Thomas AJ, Davis S, Morris C, Jackson E, Harrison R, O'Brien JT. Increase in interleukin-1beta in late-life depression. Am J Psychiatry 2005, 162:175-177. 10.1176/appi.ajp.162.1.175, 15625217.
3. Piletz JE, Halaris A, Iqbal O, Hoppensteadt D, Fareed J, Zhu H, Sinacore J, Devane CL. Pro-inflammatory biomakers in depression: treatment with venlafaxine. World J Biol Psychiatry 2009, 10:313-323. 10.3109/15622970802573246, 19921973.
4. Anisman H, Ravindran AV, Griffiths J, Merali Z. Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features. Mol Psychiatry 1999, 4:182-188. 10.1038/sj.mp.4000436, 10208451.
5. Brambilla F, Monteleone P, Maj M. Interleukin-1beta and tumor necrosis factor-alpha in children with major depressive disorder or dysthymia. J Affect Disord 2004, 78:273-277. 10.1016/S0165-0327(02)00315-4, 15013254.
6. Castanon N, Bluthe RM, Dantzer R. Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1beta in the rat. Psychopharmacology (Berl) 2001, 154:50-60.
7. Merali Z, Brennan K, Brau P, Anisman H. Dissociating anorexia and anhedonia elicited by interleukin-1beta: antidepressant and gender effects on responding for "free chow" and "earned" sucrose intake. Psychopharmacology (Berl) 2003, 165:413-418.
8. Koo JW, Duman RS. Evidence for IL-1 receptor blockade as a therapeutic strategy for the treatment of depression. Curr Opin Investig Drugs 2009, 10:664-671.
9. Norman GJ, Karelina K, Zhang N, Walton JC, Morris JS, Devries AC. Stress and IL-1beta contribute to the development of depressive-like behavior following peripheral nerve injury. Mol Psychiatry 2010, 15:404-414. 10.1038/mp.2009.91, 19773812.
10. Yu YW, Chen TJ, Hong CJ, Chen HM, Tsai SJ. Association study of the interleukin-1 beta (C-511T) genetic polymorphism with major depressive disorder, associated symptomatology, and antidepressant response. Neuropsychopharmacology 2003, 28:1182-1185.
11. Misener VL, Gomez L, Wigg KG, King N, Kiss E, Daroczi G, Kapornai K, Tamas Z, Mayer L, Gadoros J, et al. Tagging SNP association study of the IL-1beta gene (IL1B) and childhood-onset mood disorders. Am J Med Genet B Neuropsychiatr Genet 2009, 150B:653-659. 10.1002/ajmg.b.30885, 19016479.
12. Misener VL, Gomez L, Wigg KG, Luca P, King N, Kiss E, Daroczi G, Kapornai K, Tamas Z, Mayer L, et al. Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood-onset mood disorders. Neuropsychobiology 2008, 58:71-80. 10.1159/000159775, 18832862.
13. Tadic A, Rujescu D, Muller MJ, Kohnen R, Stassen HH, Szegedi A, Dahmen N. Association analysis between variants of the interleukin-1beta and the interleukin-1 receptor antagonist gene and antidepressant treatment response in major depression. Neuropsychiatr Dis Treat 2008, 4:269-276. 2515903, 18728809.
14. Baune BT, Dannlowski U, Domschke K, Janssen DG, Jordan MA, Ohrmann P, Bauer J, Biros E, Arolt V, Kugel H, et al. The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression. Biol Psychiatry 2010, 67:543-549. 10.1016/j.biopsych.2009.11.004, 20044070.
15. Holsboer F, Ising M. Stress hormone regulation: biological role and translation into therapy. Annu Rev Psychol 2010, 61:81-109, C101-111. 10.1146/annurev.psych.093008.100321, 19575614.
16. de Kloet ER, Joels M, Holsboer F. Stress and the brain: from adaptation to disease. Nat Rev Neurosci 2005, 6:463-475. 10.1038/nrn1683, 15891777.
17. Kunugi H, Urushibara T, Nanko S. Combined DEX/CRH test among Japanese patients with major depression. J Psychiatr Res 2004, 38:123-128. 10.1016/S0022-3956(03)00103-1, 14757325.
18. Kunugi H, Ida I, Owashi T, Kimura M, Inoue Y, Nakagawa S, Yabana T, Urushibara T, Kanai R, Aihara M, et al. Assessment of the dexamethasone/CRH test as a state-dependent marker for hypothalamic-pituitary-adrenal (HPA) axis abnormalities in major depressive episode: a Multicenter Study. Neuropsychopharmacology 2006, 31:212-220.
19. Raison CL, Borisov AS, Woolwine BJ, Massung B, Vogt G, Miller AH. Interferon-alpha effects on diurnal hypothalamic-pituitary-adrenal axis activity: relationship with proinflammatory cytokines and behavior. Mol Psychiatry 2010, 15:535-547. 10.1038/mp.2008.58, 18521089.
20. Bauer ME, Papadopoulos A, Poon L, Perks P, Lightman SL, Checkley S, Shanks N. Altered glucocorticoid immunoregulation in treatment resistant depression. Psychoneuroendocrinology 2003, 28:49-65. 10.1016/S0306-4530(02)00009-4, 12445836.
21. Schuld A, Schmid DA, Haack M, Holsboer F, Friess E, Pollmacher T. Hypothalamo-pituitary-adrenal function in patients with depressive disorders is correlated with baseline cytokine levels, but not with cytokine responses to hydrocortisone. J Psychiatr Res 2003, 37:463-470. 10.1016/S0022-3956(03)00054-2, 14563377.
22. Weinstein AA, Deuster PA, Francis JL, Bonsall RW, Tracy RP, Kop WJ. Neurohormonal and inflammatory hyper-responsiveness to acute mental stress in depression. Biol Psychol 2010, 84:228-234. 10.1016/j.biopsycho.2010.01.016, 2875322, 20117167.
23. Schiepers OJ, Wichers MC, Maes M. Cytokines and major depression. Prog Neuropsychopharmacol Biol Psychiatry 2005, 29:201-217. 10.1016/j.pnpbp.2004.11.003, 15694227.
24. Muller N, Schwarz MJ. The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression. Mol Psychiatry 2007, 12:988-1000. 10.1038/sj.mp.4002006, 17457312.
25. Maes M, Bosmans E, Meltzer HY, Scharpe S, Suy E. Interleukin-1 beta: a putative mediator of HPA axis hyperactivity in major depression?. Am J Psychiatry 1993, 150:1189-1193.
26. Besedovsky H, del Rey A, Sorkin E, Dinarello CA. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 1986, 233:652-654. 10.1126/science.3014662, 3014662.
27. Berkenbosch F, van Oers J, del Rey A, Tilders F, Besedovsky H. Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science 1987, 238:524-526. 10.1126/science.2443979, 2443979.
28. Hsieh CH, Li HY, Chen JC. Nitric oxide and interleukin-1beta mediate noradrenergic induced corticotrophin-releasing hormone release in organotypic cultures of rat paraventricular nucleus. Neuroscience 2010, 165:1191-1202. 10.1016/j.neuroscience.2009.12.003, 20004705.
29. Ising M, Kunzel HE, Binder EB, Nickel T, Modell S, Holsboer F. The combined dexamethasone/CRH test as a potential surrogate marker in depression. Prog Neuropsychopharmacol Biol Psychiatry 2005, 29:1085-1093. 10.1016/j.pnpbp.2005.03.014, 15950349.
30. Ising M, Horstmann S, Kloiber S, Lucae S, Binder EB, Kern N, Kunzel HE, Pfennig A, Uhr M, Holsboer F. Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker?. Biol Psychiatry 2007, 62:47-54. 10.1016/j.biopsych.2006.07.039, 17123470.
31. Schule C, Baghai TC, Eser D, Hafner S, Born C, Herrmann S, Rupprecht R. The combined dexamethasone/CRH Test (DEX/CRH test) and prediction of acute treatment response in major depression. PLoS One 2009, 4:e4324. 10.1371/journal.pone.0004324, 2629564, 19177168.
32. Binder EB, Kunzel HE, Nickel T, Kern N, Pfennig A, Majer M, Uhr M, Ising M, Holsboer F. HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients. Psychoneuroendocrinology 2009, 34:99-109. 10.1016/j.psyneuen.2008.08.018, 18829172.
33. Heuser IJ, Schweiger U, Gotthardt U, Schmider J, Lammers CH, Dettling M, Yassouridis A, Holsboer F. Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects. Am J Psychiatry 1996, 153:93-99.
34. Nickel T, Sonntag A, Schill J, Zobel AW, Ackl N, Brunnauer A, Murck H, Ising M, Yassouridis A, Steiger A, et al. Clinical and neurobiological effects of tianeptine and paroxetine in major depression. J Clin Psychopharmacol 2003, 23:155-168. 10.1097/00004714-200304000-00008, 12640217.
35. Uhart M, Chong RY, Oswald L, Lin PI, Wand GS. Gender differences in hypothalamic-pituitary-adrenal (HPA) axis reactivity. Psychoneuroendocrinology 2006, 31:642-652. 10.1016/j.psyneuen.2006.02.003, 16616815.
36. Hori H, Ozeki Y, Teraishi T, Matsuo J, Kawamoto Y, Kinoshita Y, Suto S, Terada S, Higuchi T, Kunugi H. Relationships between psychological distress, coping styles, and HPA axis reactivity in healthy adults. J Psychiatr Res 2010, 44:865-873. 10.1016/j.jpsychires.2010.02.007, 20334880.
37. Hori H, Teraishi T, Sasayama D, Ozeki Y, Matsuo J, Kawamoto Y, Kinoshita Y, Hattori K, Higuchi T, Kunugi H. Poor sleep is associated with exaggerated cortisol response to the combined dexamethasone/CRH test in a non-clinical population. J Psychiatr Res 2011,
38. Hori H, Teraishi T, Ozeki Y, Hattori K, Sasayama D, Matsuo J, Kawamoto Y, Kinoshita Y, Higuchi T, Kunugi H. Schizotypal personality in healthy adults is related to blunted cortisol responses to the combined dexamethasone/corticotropin-releasing hormone test. Neuropsychobiology 2011, 63:232-241. 10.1159/000322146, 21494051.
39. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998, 59(Suppl 20):22-33. quiz 34-57.
40. Otsubo T, Tanaka K, Koda R, Shinoda J, Sano N, Tanaka S, Aoyama H, Mimura M, Kamijima K. Reliability and validity of Japanese version of the Mini-International Neuropsychiatric Interview. Psychiatry Clin Neurosci 2005, 59:517-526. 10.1111/j.1440-1819.2005.01408.x, 16194252.
41. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265. 10.1093/bioinformatics/bth457, 15297300.
42. Wobbrock JO, Findlater L, Gergle D, Higgins JJ. The Aligned Rank Transform for Nonparametric Factorial Analyses Using Only ANOVA Procedures. Proceedings of CHI 2011 Conference on Human Factors in Computing Systems 2011, 1:143-146.
43. Binder EB, Owens MJ, Liu W, Deveau TC, Rush AJ, Trivedi MH, Fava M, Bradley B, Ressler KJ, Nemeroff CB. Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response. Arch Gen Psychiatry 2010, 67:369-379. 10.1001/archgenpsychiatry.2010.18, 20368512.
44. Kumsta R, Entringer S, Koper JW, van Rossum EF, Hellhammer DH, Wust S. Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress. Biol Psychiatry 2007, 62:863-869. 10.1016/j.biopsych.2007.04.013, 17716631.
45. Schule C, Zill P, Baghai TC, Eser D, Zwanzger P, Wenig N, Rupprecht R, Bondy B. Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients. Psychoneuroendocrinology 2006, 31:1019-1025. 10.1016/j.psyneuen.2006.06.002, 16890377.
46. Unschuld PG, Ising M, Roeske D, Erhardt A, Specht M, Kloiber S, Uhr M, Muller-Myhsok B, Holsboer F, Binder EB. Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response. Neuropsychopharmacology 2010, 35:1583-1592. 10.1038/npp.2010.30, 3055457, 20237460.
47. Heuser IJ, Gotthardt U, Schweiger U, Schmider J, Lammers CH, Dettling M, Holsboer F. Age-associated changes of pituitary-adrenocortical hormone regulation in humans: importance of gender. Neurobiol Aging 1994, 15:227-231. 10.1016/0197-4580(94)90117-1, 7838296.
48. Schmidt ED, Aguilera G, Binnekade R, Tilders FJ. Single administration of interleukin-1 increased corticotropin releasing hormone and corticotropin releasing hormone-receptor mRNA in the hypothalamic paraventricular nucleus which paralleled long-lasting (weeks) sensitization to emotional stressors. Neuroscience 2003, 116:275-283. 10.1016/S0306-4522(02)00555-9, 12535959.
49. Hwang IR, Kodama T, Kikuchi S, Sakai K, Peterson LE, Graham DY, Yamaoka Y. Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in Helicobacter pylori infection. Gastroenterology 2002, 123:1793-1803. 10.1053/gast.2002.37043, 12454835.
50. Iacoviello L, Di Castelnuovo A, Gattone M, Pezzini A, Assanelli D, Lorenzet R, Del Zotto E, Colombo M, Napoleone E, Amore C, et al. Polymorphisms of the interleukin-1beta gene affect the risk of myocardial infarction and ischemic stroke at young age and the response of mononuclear cells to stimulation in vitro. Arterioscler Thromb Vasc Biol 2005, 25:222-227.
51. Chen H, Wilkins LM, Aziz N, Cannings C, Wyllie DH, Bingle C, Rogus J, Beck JD, Offenbacher S, Cork MJ, et al. Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context. Hum Mol Genet 2006, 15:519-529. 10.1093/hmg/ddi469, 16399797.
52. Wen AQ, Wang J, Feng K, Zhu PF, Wang ZG, Jiang JX. Effects of haplotypes in the interleukin 1beta promoter on lipopolysaccharide-induced interleukin 1beta expression. Shock 2006, 26:25-30.
53. Wen AQ, Gu W, Wang J, Feng K, Qin L, Ying C, Zhu PF, Wang ZG, Jiang JX. Clinical relevance of interleukin-1beta promoter polymorphisms (-1470, -511 and -31) in patients with major trauma. Shock 2010, 33(6):576-82.
54. Hall SK, Perregaux DG, Gabel CA, Woodworth T, Durham LK, Huizinga TW, Breedveld FC, Seymour AB. Correlation of polymorphic variation in the promoter region of the interleukin-1 beta gene with secretion of interleukin-1 beta protein. Arthritis Rheum 2004, 50:1976-1983. 10.1002/art.20310, 15188375.
55. Lekander M, Axen J, Knutsson U, Olgart Hoglund C, Werner S, Wikstrom AC, Stierna P. Cytokine inhibition after glucocorticoid exposure in healthy men with low versus high basal cortisol levels. Neuroimmunomodulation 2009, 16:245-250. 10.1159/000212385, 19365148.
56. Jeon YJ, Han SH, Lee YW, Lee M, Yang KH, Kim HM. Dexamethasone inhibits IL-1 beta gene expression in LPS-stimulated RAW 264.7 cells by blocking NF-kappa B/Rel and AP-1 activation. Immunopharmacology 2000, 48:173-183. 10.1016/S0162-3109(00)00199-5, 10936515.
57. Heuser I, Yassouridis A, Holsboer F. The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders. J Psychiatr Res 1994, 28:341-356. 10.1016/0022-3956(94)90017-5, 7877114.
58. Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 2000, 23:477-501. 10.1016/S0893-133X(00)00159-7, 11027914.
59. Schule C, Baghai T, Zwanzger P, Ella R, Eser D, Padberg F, Moller HJ, Rupprecht R. Attenuation of hypothalamic-pituitary-adrenocortical hyperactivity in depressed patients by mirtazapine. Psychopharmacology (Berl) 2003, 166:271-275.