Differential effects of low versus high amounts of weight supported treadmill training in spinally transected rats

Journal of Neurotrauma

Volumn 28, Issue 6, 2011, Pages 1021-1033

  De Leon, Ray D ^a   See, Pamela A ^a   Chow, Cheryl H T ^a  

^a CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

growth factors; rehabilitation; spinal cord injury

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; HEAT SHOCK PROTEIN 27; NEURON SPECIFIC NUCLEAR PROTEIN; PRESYNAPTIC RECEPTOR; SYNAPTOPHYSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; EXERCISE INTENSITY; FEMALE; FUNCTIONAL ASSESSMENT; FUNCTIONAL TRAINING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LOCOMOTION; LUMBAR SPINAL CORD; MOTONEURON; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; RAT; SPINAL CORD FUNCTION; SPINAL CORD INJURY; SPINAL CORD TRANSSECTION; SPINAL CORD VENTRAL HORN; TREADMILL; TREADMILL EXERCISE; TREATMENT OUTCOME; WEIGHT SUPPORTED TREADMILL TRAINING;

ANIMALS; BODY WEIGHT; DISEASE MODELS, ANIMAL; EXERCISE TEST; EXERCISE THERAPY; FEMALE; PARAPLEGIA; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES;

EID: 79959748906     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2010.1699     Document Type: Article

References (32)

1. Barbeau, H., and Rossignol, S. (1987). Recovery of locomotion after chronic spinalization in the adult cat. Brain Res. 412, 84-95. (Pubitemid 17096686)
2. Beaumont, E., Kaloustian, S., Rousseau, G., and Cormery, B. (2008). Training improves the electrophysiological properties of lumbar neurons and locomotion after thoracic spinal cord injury in rats. Neurosci. Res. 62, 147-154.
3. Behrman, A.L., and Harkema, S.J. (2000). Locomotor training after human spinal cord injury: a series of case studies. Phys. Ther. 80, 688-700. (Pubitemid 30441698)
4. Belanger, M., Drew, T., Provencher, J., and Rossignol, S. (1996). A comparison of treadmill locomotion in adult cats before and after spinal transection. J. Neurophysiol. 76, 471-491. (Pubitemid 26251182)
5. Cha, J., Heng, C., Reinkensmeyer, D.J., Roy, R.R., Edgerton, V.R., and de Leon, R.D. (2007). Locomotor ability in spinal rats is dependent on the amount of activity imposed on the hindlimbs during treadmill training. J. Neurotrauma 24, 1000-1012. (Pubitemid 47015434)
6. Cotman, C.W., Berchtold, N.C., and Christie, L.A. (2007). Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 30, 464-472. (Pubitemid 47374831)
7. de Leon, R.D., and Acosta, C.A. (2006). Effect of robotic-assisted treadmill training and chronic quipazine treatment on hindlimb stepping in spinally transected rats. J. Neurotrauma 23, 1147-1163. (Pubitemid 44162719)
8. de Leon, R.D., Hodgson, J.A., Roy, R.R., and Edgerton, V.R. (1998). Locomotor capacity attributable to step training versus spontaneous recovery after spinalization in adult cats. J. Neurophysiol. 79, 1329-1340. (Pubitemid 28125368)
9. Edgerton, V. R., de Leon, R.D., Tillakaratne, N., Recktenwald, M.R., Hodgson, J.A., and Roy, R.R. (1997). Use-dependent plasticity in spinal stepping and standing. Adv. Neurol. 72, 233-247.
10. Edgerton, V.R., Tillakaratne, N.J., Bigbee, A.J., de Leon, R.D., and Roy, R.R. (2004). Plasticity of the spinal neural circuitry after injury. Annu. Rev. Neurosci. 27, 145-167. (Pubitemid 39050400)
11. Gao, Y., Bezchlibnyk, Y.B., Sun, X., Wang, J.F., McEwen, B.S., and Young, L.T. (2006). Effects of restraint stress on the expression of proteins involved in synaptic vesicle exocytosis in the hippocampus. Neuroscience 141, 1139-1148. (Pubitemid 44128680)
12. Giszter, S.F., Kargo, W.J., Davies, M., and Shibayama, M. (1998). Fetal transplants rescue axial muscle representations in M1 cortex of neonatally transected rats that develop weight support. J. Neurophysiol. 80, 3021-3030. (Pubitemid 29029231)
13. Gomez-Pinilla, F., Ying, Z., Opazo, P., Roy, R.R., and Edgerton, V.R. (2001). Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle. Eur. J. Neurosci. 13, 1078-1084. (Pubitemid 32275744)
14. Heng, C., and de Leon, R.D. (2009). Treadmill training enhances the recovery of normal stepping patterns in spinal cord contused rats. Exp. Neurol. 216, 139-147.
15. Hodgson, J.A., Roy, R.R., de Leon, R., Dobkin, B., and Edgerton, V.R. (1994). Can the mammalian lumbar spinal cord learn a motor task? Med. Sci. Sports Exerc. 26, 1491-1497.
16. Hutchinson, K.J., Gomez-Pinilla, F., Crowe, M.J., Ying, Z., and Basso, D.M. (2004). Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats. Brain 127, 1403-1414. (Pubitemid 38745518)
17. Ichiyama, R.M., Broman, J., Edgerton, V.R., and Havton, L.A. (2006). Ultrastructural synaptic features differ between alphaand gamma-motoneurons innervating the tibialis anterior muscle in the rat. J. Comp. Neurol. 499, 306-315. (Pubitemid 44454068)
18. Ichiyama, R.M., Broman, J., Roy, R.R., Zhong, H., Edgerton, V.R., and Havton, L.A. (2011). Locomotor training maintains normal inhibitory influence on both alpha- and gammamotoneurons after neonatal spinal cord transection. J. Neurosci. 31, 26-33.
19. Kubasak, M.D., Hedlund, E., Roy, R.R., Carpenter, E.M., Edgerton, V.R., and Phelps, P.E. (2005). L1 CAM expression is increased surrounding the lesion site in rats with complete spinal cord transection as neonates. Exp. Neurol. 194, 363-375. (Pubitemid 40966996)
20. Lovely, R.G., Gregor, R.J., Roy, R.R., and Edgerton, V.R. (1986). Effects of training on the recovery of full-weight-bearing stepping in the adult spinal cat. Exp. Neurol. 92, 421-435. (Pubitemid 16121104)
21. Lovely, R.G., Gregor, R.J., Roy, R.R., and Edgerton, V.R. (1990). Weight-bearing hindlimb stepping in treadmill-exercised adult spinal cats. Brain Res. 514, 206-218. (Pubitemid 20151373)
22. Macias, M., Dwornik, A., Ziemlinska, E., Fehr, S., Schachner, M., Czarkowska-Bauch, J., and Skup, M. (2007). Locomotor exercise alters expression of pro-brain-derived neurotrophic factor, brain-derived neurotrophic factor and its receptor TrkB in the spinal cord of adult rats. Eur. J. Neurosci. 25, 2425-2444. (Pubitemid 46625928)
23. Macias, M., Nowicka, D., Czupryn, A., Sulejczak, D., Skup, M., Skangiel-Kramska, J., and Czarkowska-Bauch, J. (2009). Exercise-induced motor improvement after complete spinal cord transection and its relation to expression of brain-derived neurotrophic factor and presynaptic markers. BMC Neurosci. 10, 144.
24. Petruska, J.C., Ichiyama, R.M., Jindrich, D.L., Crown, E.D., Tansey, K.E., Roy, R.R., Edgerton, V.R., and Mendell, L.M. (2007). Changes in motoneuron properties and synaptic inputs related to step training after spinal cord transection in rats. J. Neurosci. 27, 4460-4471. (Pubitemid 46640712)
25. Plumier, J.C., Hopkins, D.A., Robertson, H.A., and Currie, R.W. (1997). Constitutive expression of the 27-kDa heat shock protein (Hsp27) in sensory and motor neurons of the rat nervous system. J. Comp. Neurol. 384, 409-428. (Pubitemid 27342584)
26. Skup, M., Dwornik, A., Macias, M., Sulejczak, D., Wiater, M., and Czarkowska-Bauch, J. (2002). Long-term locomotor training up-regulates TrkB(FL) receptor-like proteins, brainderived neurotrophic factor, and neurotrophin 4 with different topographies of expression in oligodendroglia and neurons in the spinal cord. Exp. Neurol. 176, 289-307. (Pubitemid 35193346)
27. Sullivan, K.J., Brown, D.A., Klassen, T., Mulroy, S., Ge, T., Azen, S.P., and Winstein. C.J. (2007). Effects of task-specific locomotor and strength training in adults who were ambulatory after stroke: results of the STEPS randomized clinical trial. Phys. Ther. 87, 1580-1602. (Pubitemid 350230746)
28. Tillakaratne, N.J., de Leon, R.D., Hoang, T.X., Roy, R.R., Edgerton, V.R., and Tobin, A.J. (2002). Use-dependent modulation of inhibitory capacity in the feline lumbar spinal cord. J. Neurosci. 22, 3130-3143. (Pubitemid 35379202)
29. Weber, E.D., and Stelzner, D.J. (1977). Behavioral effects of spinal cord transection in the developing rat. Brain Res. 125, 241-255. (Pubitemid 8088938)
30. Wernig, A., Muller, S., Nanassy, A., and Cagol. E. (1995). Laufband therapy based on rules of spinal locomotion is effective in spinal cord injured persons. Eur. J. Neurosci. 7, 823-829.
31. Ying, Z., Roy, R.R., Edgerton, V.R., and Gomez-Pinilla, F. (2005). Exercise restores levels of neurotrophins and synaptic plasticity following spinal cord injury. Exp. Neurol. 193, 411-419. (Pubitemid 40626768)
32. Ying, Z., Roy, R.R., Zhong, H., Zdunowski, S., Edgerton, V.R., and Gomez-Pinilla, F. (2008). BDNF-exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in rats. Neuroscience 155, 1070-1078.