PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma

British Journal of Cancer

Volumn 105, Issue 1, 2011, Pages 124-130

  Keld, R ^a   Guo, B ^a   Downey, P ^b   Cummins, R ^c   Gulmann, C ^b   Ang, Y S ^a   Sharrocks, A D ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b BEAUMONT HOSPITAL   (Ireland)

^c ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

ER81; ETV1; ETV4; gastric cancer; MMP1; PEA3

Indexed keywords

INTERSTITIAL COLLAGENASE; MATRILYSIN; MESSENGER RNA; RAS PROTEIN; TRANSCRIPTION FACTOR PEA3;

ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STOMACH ADENOCARCINOMA; SURVIVAL RATE; TUMOR CELL; UPREGULATION;

ADENOCARCINOMA; CASE-CONTROL STUDIES; DNA-BINDING PROTEINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; IMMUNOENZYME TECHNIQUES; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 7; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STOMACH; STOMACH NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 79959742995     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2011.187     Document Type: Article

References (44)

1. Bao W, Fu HJ, Jia LT, Zhang Y, Li W, Jin BQ, Yao LB, Chen SY, Yang AG (2010) HER2-mediated upregulation of MMP-1 is involved in gastric cancer cell invasion. Arch Biochem Biophys 499: 49-55
2. Boros J, O'Donnell A, Donaldson IJ, Kasza A, Zeef L, Sharrocks AD (2009) Overlapping promoter targeting by Elk-1 and other divergent ETS-domain transcription factor family members. Nucleic Acids Res 37: 7368-7380
3. Bosetti C, Bertuccio P, Levi F, Lucchini F, Negri E, La Vecchia C (2008) Cancer mortality in the European Union, 1970-2003, with a joinpoint analysis. Ann Oncol 19: 631-640 (Pubitemid 351461031)
4. Brown LA, Amores A, Schilling TF, Jowett T, Baert JL, de Launoit Y, Sharrocks AD (1998) Molecular characterization of the zebrafish PEA3 ETS-domain transcription factor. Oncogene 17: 93-104 (Pubitemid 28360533)
5. Cai C, Hsieh CL, Omwancha J, Zheng Z, Chen SY, Baert JL, Shemshedini L (2007) ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion. Mol Endocrinol 21: 1835-1846 (Pubitemid 47173795)
6. Chi P, Chen Y, Zhang L, Guo X, Wongvipat J, Shamu T, Fletcher JA, Dewell S, Maki RG, Zheng D, Antonescu CR, Allis CD, Sawyers CL (2010) ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours. Nature 467: 849-853
7. Cowden Dahl KD, Zeineldin R, Hudson LG (2007) PEA3 is necessary for optimal epidermal growth factor receptor-stimulated matrix metallopro-teinase expression and invasion of ovarian tumor cells. Mol Cancer Res 5: 413-421 (Pubitemid 46903950)
8. Crawford HC, Fingleton B, Gustavson MD, Kurpios N, Wagenaar RA, Hassell JA, Matrisian LM (2001) The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors. Mol Cell Biol 21: 1370-1383 (Pubitemid 32114984)
9. Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, Scarffe JH, Lofts FJ, Falk SJ, Iveson TJ, Smith DB, Langley RE, Verma M, Weeden S, Chua YJ, Participants MT (2006) Perioperative chemotherapy vs surgery alone for resectable gastroesophageal cancer. N Engl J Med 355: 11-20
10. de Launoit Y, Baert JL, Chotteau-Lelievre A, Monte D, Coutte L, Mauen S, Firlej V, Degerny C, Verreman K (2006) The Ets transcription factors of the PEA3 group: transcriptional regulators in metastasis. Biochim Biophys Acta 1766: 79-87 (Pubitemid 44202569)
11. de Launoit Y, Baert JL, Chotteau A, Monte D, Defossez PA, Coutte L, Pelczar H, Leenders F (1997) Structure-function relationships of the PEA3 group of Ets-related transcription factors. Biochem Mol Med 61: 127-135 (Pubitemid 27347215)
12. de Launoit Y, Chotteau-Lelievre A, Beaudoin C, Coutte L, Netzer S, Brenner C, Huvent I, Baert JL (2000) The PEA3 group of ETS-related transcription factors. Role in breast cancer metastasis. Adv Exp Med Biol 480: 107-116 (Pubitemid 32176100)
13. Feng W, Brown RE, Trung CD, Li W, Wang L, Khoury T, Alrawi S, Yao J, Xia K, Tan D (2008) Morphoproteomic profile of mTOR, Ras/Raf kinase/ ERK, and NF-kappaB pathways in human gastric adenocarcinoma. Ann Clin Lab Sci 38: 195-209
14. Findlay M, Cunningham D, Norman A, Mansi J, Nicolson M, Hickish T, Nicolson V, Nash A, Sacks N, Ford H, Carter R, Hill A (1994) A phase II study in advanced gastro-esophageal cancer using epirubicin and cisplatin in combination with continuous infusion 5-fluorouracil (ECF). Ann Oncol 5: 609-616 (Pubitemid 24283097)
15. Goel A, Janknecht R (2004) Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu. J Biol Chem 279: 14909-14916 (Pubitemid 38618881)
16. Gum R, Lengyel E, Juarez J, Chen JH, Sato H, Seiki M, Boyd D (1996) Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences. J Biol Chem 271: 10672-10680
17. Guo B, Sallis RE, Greenall A, Petit MM, Jansen E, Young L, Van de Ven WJ, Sharrocks AD (2006) The LIM domain protein LPP is a coactivator for the ETS domain transcription factor PEA3. Mol Cell Biol 26: 4529-4538 (Pubitemid 43877573)
18. Guo B, Sharrocks AD (2009) Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcrip-tional activator PEA3. Mol Cell Biol 29: 3204-3218
19. Guo B, Yang SH, Witty J, Sharrocks AD (2007) Signalling pathways and the regulation of SUMO modification. Biochem Soc Trans 035: 1414-1418
20. Habelhah H, Okada F, Kobayashi M, Nakai K, Choi S, Hamada J, Moriuchi T, Kaya M, Yoshida K, Fujinaga K, Hosokawa M (1999) Increased E1AF expression in mouse fibrosarcoma promotes metastasis through induction of MT1-MMP expression. Oncogene 18: 1771-1776 (Pubitemid 29137468)
21. Hollenhorst PC, Shah AA, Hopkins C, Graves BJ (2007) Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev 21: 1882-1894 (Pubitemid 47204928)
22. Horiuchi S, Yamamoto H, Min Y, Adachi Y, Itoh F, Imai K (2003) Association of ets-related transcriptional factor E1AF expression with tumour progression and overexpression of MMP-1 and matrilysin in human colorectal cancer. J Pathol 200: 568-576 (Pubitemid 36987305)
23. Howe LR, Crawford HC, Subbaramaiah K, Hassell JA, Dannenberg AJ, Brown AM (2001) PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2. J Biol Chem 276: 20108-20115
24. Hua D, Chen B, Bai M, Yu H, Wu X, Jin W (2009) PEA3 activates VEGF transcription in T47D and SKBR3 breast cancer cells. Acta Biochim Biophys Sin (Shanghai) 41: 63-68
25. Janknecht R (2003) Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). Oncogene 22: 746-755 (Pubitemid 36269288)
26. Jiang J, Wei Y, Liu D, Zhou J, Shen J, Chen X, Zhang S, Kong X, Gu J (2007) E1AF promotes breast cancer cell cycle progression via upregulation of Cyclin D3 transcription. Biochem Biophys Res Commun 358: 53-58 (Pubitemid 46729543)
27. Keld R, Guo B, Downey P, Gulmann C, Ang YS, Sharrocks AD (2010) The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma. Molecular Cancer 9: 313
28. Liu Y, Borchert GL, Phang JM (2004) Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells. J Biol Chem 279: 18694-18700 (Pubitemid 38623293)
29. Mackay HJ, McInnes A, Paul J, Raby N, Lofts FJ, McDonald AC, Soukop M, Fullarton GM, Harris AL, Garcia-Vargas J, Evans TR (2001) A phase II study of epirubicin, cisplatin and raltitrexed combination chemotherapy (ECT) in patients with advanced oesophageal and gastric adenocarcino-ma. Ann Oncol 12: 1407-1410 (Pubitemid 33100246)
30. Matsui K, Sugimori K, Motomura H, Ejiri N, Tsukada K, Kitajima I (2006) PEA3 cooperates with c-Jun in regulation of HER2/neu transcription. Oncol Rep 16: 153-158
31. Nosho K, Yoshida M, Yamamoto H, Taniguchi H, Adachi Y, Mikami M, Hinoda Y, Imai K (2005) Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis. Carcinogenesis 26: 892-899 (Pubitemid 41214317)
32. O'Hagan RC, Hassell JA (1998) The PEA3 Ets transcription factor is a downstream target of the HER2/Neu receptor tyrosine kinase. Oncogene 16: 301-310 (Pubitemid 28052284)
33. Oikawa T, Yamada T (2003) Molecular biology of the Ets family of transcription factors. Gene 303: 11-34 (Pubitemid 36151767)
34. Rachet B, Maringe C, Nur U, Quaresma M, Shah A, Woods LM, Ellis L, Walters S, Forman D, Steward J, Coleman MP (2009) Population-based cancer survival trends in England and Wales up to 2007: an assessment of the NHS cancer plan for England. Lancet Oncol 10: 351-369
35. Rinehart J, Adjei AA, Lorusso PM, Waterhouse D, Hecht JR, Natale RB, Hamid O, Varterasian M, Asbury P, Kaldjian EP, Gulyas S, Mitchell DY, Herrera R, Sebolt-Leopold JS, Meyer MB (2004) Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. J Clin Oncol 22: 4456-4462 (Pubitemid 41185111)
36. Rojo F, Tabernero J, Albanell J, Van Cutsem E, Ohtsu A, Doi T, Koizumi W, Shirao K, Takiuchi H, Ramon Y, Cajal S, Baselga J (2006) Pharmacody-namic studies of gefitinib in tumor biopsy specimens from patients with advanced gastric carcinoma. J Clin Oncol 24: 4309-4316 (Pubitemid 46630789)
37. Samalin E, Ychou M (2007) Neoadjuvant treatment in upper gastrointestinal adenocarcinomas: new paradigms from old concepts? Curr Opin Oncol 19: 384-389 (Pubitemid 46883531)
38. Sharrocks AD (2001) The ETS-domain transcription factor family. Nat Rev Mol Cell Biol 2: 827-837 (Pubitemid 33674083)
39. Tan YK, Fielding JW (2006) Early diagnosis of early gastric cancer. Eur J Gastroenterol Hepatol 18: 821-829 (Pubitemid 44034794)
40. Tebbutt NC, Norman A, Cunningham D, Iveson T, Seymour M, Hickish T, Harper P, Maisey N, Mochlinski K, Prior Y, Hill M (2002) A multicentre, randomised phase III trial comparing protracted venous infusion (PVI) 5-fluorouracil (5-FU) with PVI 5-FU plus mitomycin C in patients with inoperable oesophago-gastric cancer. Ann Oncol 13: 1568-1575 (Pubitemid 35339322)
41. Tomlins SA, Laxman B, Dhanasekaran SM, Helgeson BE, Cao X, Morris DS, Menon A, Jing X, Cao Q, Han B, Yu J, Wang L, Montie JE, Rubin MA, Pienta KJ, Roulston D, Shah RB, Varambally S, Mehra R, Chinnaiyan AM (2007) Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. Nature 448: 595-599 (Pubitemid 47206938)
42. Vrieseling E, Arber S (2006) Target-induced transcriptional control of dendritic patterning and connectivity in motor neurons by the ETS gene Pea3. Cell 127: 1439-1452 (Pubitemid 44960407)
43. Wu JY, Lu H, Sun Y, Graham DY, Cheung HS, Yamaoka Y (2006) Balance between polyoma enhancing activator 3 and activator protein 1 regulates Helicobacter pylori-stimulated matrix metalloproteinase 1 expression. Cancer Res 66: 5111-5120 (Pubitemid 43844933)
44. Yamamoto H, Horiuchi S, Adachi Y, Taniguchi H, Nosho K, Min Y, Imai K (2004) Expression of ets-related transcriptional factor E1AF is associated with tumor progression and over-expression of matrilysin in human gastric cancer. Carcinogenesis 25: 325-332 (Pubitemid 38344398)