CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome

Fertility and Sterility

Volumn 95, Issue 8, 2011, Pages 2651-2654

  Niccoli, Giampaolo ^a   Apa, Rosanna ^a   Lanzone, Antonio ^b   Liuzzo, Giovanna ^a   Spaziani, Cristina ^a   Sagnella, Francesca ^a   Cosentino, Nicola ^a   Moro, Francesca ^a   Martinez, Daniela ^a   Morciano, Andrea ^a   Bac, Marco ^a   Pazzano, Vincenzo ^a   Gangale, Maria Francesca ^a   Tropea, Anna ^a   Crea, Filippo ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b OASI RESEARCH INSTITUTE IRCCS   (Italy)

Author keywords

Hyperinsulinemia; inflammation; polycystic ovary syndrome; T lymphocytes

Indexed keywords

C REACTIVE PROTEIN; FOLLITROPIN; LUTEINIZING HORMONE; MEDROXYPROGESTERONE ACETATE;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CD4+ CD28+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL FUNCTION; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; FEMALE; FOLLITROPIN BLOOD LEVEL; HEART INFARCTION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERINSULINEMIA; HYPERTENSION; LUTEINIZING HORMONE BLOOD LEVEL; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ANTIGENS, CD28; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; FEMALE; HUMANS; HYPERINSULINISM; INFLAMMATION MEDIATORS; ITALY; LINEAR MODELS; POLYCYSTIC OVARY SYNDROME; RISK ASSESSMENT; RISK FACTORS; YOUNG ADULT;

EID: 79959742566     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2011.01.129     Document Type: Article

References (31)

1. M. Stramba-Badiale, K.M. Fox, S.G. Priori, P. Collins, C. Daly, and I. Graham Cardiovascular diseases in women: a statement from the policy conference of the European Society of Cardiology Eur Heart J 27 2006 994 1005
2. E. Talbott, D. Guzick, A. Clerici, S. Berga, K. Detre, and K. Weimer Coronary heart disease risk factors in women with polycystic ovary syndrome Arterioscler Thromb Vasc Biol 15 1995 821 826
3. D. Cibula, R. Cífková, M. Fanta, R. Poledne, J. Zivny, and J. Skibová Increased risk of non-insulin dependent diabetes mellitus, arterial hypertension, and coronary artery disease in perimenopausal women with a history of the polycystic ovary syndrome Hum Reprod 15 2000 785 789 (Pubitemid 30192723)
4. S. Franks Polycystic ovary syndrome N Engl J Med 333 1995 853 861
5. A.M. Scarpitta, and D. Sinagra Polycystic ovary syndrome: an endocrine and metabolic disease Gynecol Endocrinol 14 2000 392 395
6. R.S. Legro Diabetes prevalence and risk factors in polycystic ovarian syndrome Obstet Gynecol Clin North Am 28 2001 99 109 (Pubitemid 32242543)
7. A. Dunaif, K.R. Segal, W. Futterweit, and A. Dobrjansky Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome Diabetes 38 1989 1165 1174 (Pubitemid 19250404)
8. C.C. Kelly, H. Lyall, J.R. Petrie, G.W. Gould, J.M. Connell, and N. Sattar Low-grade chronic inflammation in women with polycystic ovarian syndrome J Clin Endocrinol Metab 86 2001 2453 2455 (Pubitemid 32545690)
9. M. Schachter, A. Raziel, S. Friedler, D. Strassburger, O. Bern, and R. Ron-El Insulin resistance in patients with polycystic ovary syndrome is associated with elevated plasma homocysteine Hum Reprod 18 2003 721 727 (Pubitemid 36426948)
10. R.S. Legro, A.R. Kunselman, W.C. Dodson, and A. Dunaif Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective controlled study in 254 affected women J Clin Endocrinol Metab 84 1999 165 169 (Pubitemid 29036695)
11. T. Apridonidze, P.A. Essah, M.J. Iuorno, and J.E. Nestler Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome J Clin Endocrinol Metab 90 2005 1929 1935 (Pubitemid 40586223)
12. C.J. Kelly, A. Speirs, G.W. Gould, J.R. Petrie, H. Lyall, and J.M. Connell Altered vascular function in young women with polycystic ovary syndrome J Clin Endocrinol Metab 87 2002 742 746 (Pubitemid 34158246)
13. E.O. Talbott, D.S. Guzick, K. Sutton-Tyrrell, K.P. McHugh-Pemu, J.V. Zborowski, and K.E. Remsberg Evidence for association between polycystic ovary syndrome and premature carotid atherosclerosis in middle-aged women Arterioscler Thromb Vasc Biol 20 2000 2414 2421
14. C. Battaglia, F. Mancini, A. Cianciosi, P. Busacchi, N. Persico, and R. Paradisi Cardiovascular risk in normal weight, eumenorrheic, nonhirsute daughters of patients with polycystic ovary syndrome: a pilot study Fertil Steril 92 2009 240 249
15. Giubilato S., Brugaletta S., Smaldone C., Pazzano V., Pitocco D., Ghirlanda G., et al. Cardiovascular risk in T2DM: The role of an unusual T cell population. 10-A-12489- December 2009, ACC Abstract).
16. - T cells in the aging immune system Mech Ageing Dev 102 1998 131 147 (Pubitemid 28353534)
17. T. Nakajima, S. Schulte, K.J. Warrington, S.L. Kopecky, R.L. Frye, and J.J. Goronzy T-cell-mediated lysis of endothelial cells in acute coronary syndromes Circulation 105 2002 570 575 (Pubitemid 34123430)
18. T. Namekawa, U.G. Wagner, J.J. Goronzy, and C.M. Weyand Functional subsets of CD4 T cells in rheumatoid synovitis Arthritis Rheum 41 1998 2108 2116 (Pubitemid 29009368)
19. G. Liuzzo, S.L. Kopecky, R.L. Frye, W.M. O'Fallon, A. Maseri, and J.J. Goronzy Perturbation of the T-cell repertoire in patients with unstable angina Circulation 100 1999 2135 2139
20. G. Liuzzo, L.M. Biasucci, G. Trotta, S. Brugaletta, M. Pinnelli, and G. Digianuario Unusual CD4+CD28null T lymphocytes and recurrence of acute coronary events J Am Coll Cardiol 50 2007 1450 1458 (Pubitemid 47494592)
21. G. Liuzzo, J.J. Goronzy, H. Yang, S.L. Kopecky, D.R. Holmes, and R.L. Frye Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes Circulation 101 2000 2883 2888 (Pubitemid 30415876)
22. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome Fertil Steril 81 2004 19 25
23. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) Final Report Circulation 106 2002 3143-3421
24. M. Ciampelli, F. Leoni, F. Cucinelli, S. Mancuso, S. Panunzi, and A. De Gaetano Assessment of insulin sensitivity from measurements in the fasting state and during an oral glucose tolerance test in polycystic ovary syndrome and menopausal patients J Clin Endocrinol Metab 90 2005 1398 1406 (Pubitemid 40463995)
25. M. Schirmer, A.N. Vallejo, C.M. Weyand, and J.J. Goronzy Resistance to apoptosis and elevated expression of Bcl-2 in clonally expanded CD4+CD28-T cells from rheumatoid arthritis patients J Immunol 161 1998 1018 1025 (Pubitemid 28323570)
26. H.F. Alber, C. Duftner, M. Wanitschek, J. Dörler, M. Schirmer, and A. Suessenbacher CD4+CD28-lymphocytes and the extent and severity of coronary artery disease Int J Cardiol 135 2009 27 35
27. M. McMahona, and B.H. Hahna Atherosclerosis and systemic lupus erythematosus: mechanistic basis of the association Curr Opin Immunol 19 2007 633 639
28. C. Tanasescu, C. Jurcut, R. Jurcut, and C. Ginghina Vascular disease in rheumatoid arthritis: from subclinical lesions to cardiovascular risk Eur J Intern Med 20 2009 348 354
29. C.M. Weyand, and J.J. Goronzy T-cell responses in rheumatoid arthritis: systemic abnormalities-local disease Curr Opin Rheumatol 11 1999 210 217 (Pubitemid 29257639)
30. L.H. Kuller, R.P. Tracy, J. Shaten, and E.N. Meilahn Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Multiple Risk Factor Intervention Trial Am J Epidemiol 144 1996 537 547 (Pubitemid 26304398)
31. L.M. Biasucci, G. Liuzzo, R.L. Grillo, G. Caligiuri, A.G. Rebuzzi, and A. Buffon Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability Circulation 99 1999 855 860 (Pubitemid 29094296)