Experimental and numerical analysis of high-resolution injection technique for capillary electrophoresis microchip

International Journal of Molecular Sciences

Volumn 12, Issue 6, 2011, Pages 3594-3605

  Chang, Chin Lung ^a   Leong, Jik Chang ^a   Hong, Ting Fu ^a   Wang, Yao Nan ^a   Fu, Lung Ming ^a  

^a NATIONAL PINGTUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Capillary electrophoresis microchip; Expansion chamber; Injection system

Indexed keywords

DNA; RHODAMINE B; GGCC-SPECIFIC TYPE II DEOXYRIBONUCLEASES; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE;

ARTICLE; CAPILLARY ELECTROPHORESIS; EQUIPMENT DESIGN; EXPERIMENTAL STUDY; MATHEMATICAL MODEL; MICROCHIP ELECTROPHORESIS; MICROFLUIDICS; SEPARATION TECHNIQUE; DEVICES; ISOLATION AND PURIFICATION; METABOLISM; MICROFLUIDIC ANALYSIS;

DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA; ELECTROPHORESIS, MICROCHIP; MICROFLUIDIC ANALYTICAL TECHNIQUES;

EID: 79959715845     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms12063594     Document Type: Article

References (48)

1. Fu, L.M.; Lin, C.H. A rapid DNA digestion system. Biomed. Microdevices 2007, 9, 277-286.
2. Tsai, C.H.; Hou, H.H.; Fu, L.M. An optimal three-dimensional focusing technique for micro-flow cytometers. Microfluid. Nanofluid. 2008, 5, 827-836.
3. Liu, D.; Chen, B.; Wang, L.; Zhou, X. On-chip coupling of free-solution transient ITP and CGE for highly efficient separation of dsDNA with variable sample loading amounts. Electrophoresis 2009, 30, 4300-4305.
4. Wen, C.Y.; Lee, T.L.; Tsai, C.H.; Fu, L.M. Rapid magnetic microfluidic mixer utilizing AC electromagnetic field. Electrophoresis 2009, 30, 4179-4186.
5. Wang, J.; Wang, C.; Lin, C.; Lei, H.; Lee, G. An integrated microfluidic system for counting of CD4+/CD8+ T lymphocytes. Microfluid. Nanofluid. 2010, 6, 739-749.
6. Xuan, X.; Zhu, J.; Churc, C. Particle focusing in microfluidic devices. Microfluid. Nanofluid. 2010, 9, 1-16.
7. Rosenauer, M.; Vellekoop, M.J. Characterization of a microflow cytometer with an integrated three-dimensional optofluidic lens system. Biomicrofluidics 2010, 4, 043005.
8. Zeng, J. Non-Linear Electrohydrodynamics in Microfluidic Devices. Int. J. Mol. Sci. 2011, 12, 1633-1649.
9. Nieuwstadt, H.; Seda, R.; Li, D.; Fowlkes, J.; Bull, J. Microfluidic particle sorting utilizing inertial lift force. Biomed. Microdevices 2011, 13, 97-105.
10. Guo, W.; Lau, K.; Fung, Y. Microfluidic chip-capillary electrophoresis for two orders extension of adjustable upper working range for profiling of inorganic and organic anions in urine. Electrophoresis 2010, 31, 3044-3052.
11. Cao, B.; Sun, J.; Chen, M.; Guo, Z. Molecular momentum transport at fluid-solid interfaces in MEMS/NEMS: A review. Int. J. Mol. Sci. 2009, 10, 4638-4706.
12. Johns, C.; Breadmore, M.C.; Macka, M.; Ryvolova, M.; Haddad, P.R. Recent significant developments in detection and method development for the determination of inorganic ions by CE. Electrophoresis 2009, 30, S53-S67.
13. Fernandes, P. Miniaturization in Biocatalysis. Int. J. Mol. Sci. 2010, 11, 858-879.
14. Hong, T.F.; Ju, W.J.; Wu, M.; Tai, C.H.; Tsai, C.H.; Fu, L.M. Rapid prototyping of PMMA microfluidic chips utilizing a CO2 laser. Microfluid. Nanofluid. 2010, 9, 1125-1133.
15. Sun, H.; Nie, Z.; Fung, Y.S. Determination of free bilirubin and its binding capacity by HSA using a microfluidic chip-capillary electrophoresis device with a multi-segment circular-ferrofluid-driven micromixing injection. Electrophoresis 2010, 31, 3061-3069.
16. Chuang, H.; Jacobson, S.; Wereley, S. A diffusion-based cyclic particle extractor. Microfluid. Nanofluid. 2010, 9, 743-753.
17. Wang, A.; Cheng, C.; Lin, I.; Lu, F.; Tsai, H.; Lin, C.; Yang, C.; Pan, P.; Kuan, C.; Chen, Y.; Lin, Y.; Chang, C.; Wu, Y.; Kurniawan, T.; Lin, C.; Wo, A.; Chen, L. A novel DNA selection and direct extraction process and its application in DNA recombination. Electrophoresis 2011, 32, 423-430.
18. Oh, K.; Smith, B.; Devasia, S.; Riley, J.; Chung, J. Characterization of mixing performance for bio-mimetic silicone cilia. Microfluid. Nanofluid. 2010, 9, 645-655.
19. Tofteberg, T.; Skolimowski, M.; Andreassen, E.; Geschke, O. A novel passive micromixer: Lamination in a planar channel system. Microfluid. Nanofluid. 2010, 8, 209-215.
20. Mao, X.; Juluri, B.; Lapsley, M.; Stratton, Z.; Huang, T. Milliseconds microfluidic chaotic bubble mixer. Microfluid. Nanofluid. 2010, 8, 139-144.
21. Hao, G.H.; Duits, M.; Mugele, F. Droplets formation and merging in two-phase flow microfluidics. Int. J. Mol. Sci. 2011, 12, 2572-2597.
22. Fu, L.M.; Lin, C.H. Numerical analysis and experimental estimation of a low leakage injection technique for capillary electrophoresis. Anal. Chem. 2003, 75, 5790-5796.
23. Lin, C.H.; Yang, R.J.; Tai, C.H.; Lee, C.Y.; Fu, L.M. Double-L injection technique for high performance CE detection in microfluidic chips. J. Micromech. Microeng. 2004, 14, 639-646.
24. Tsai, C.H.; Yang, R.J.; Tai, C.H.; Fu, L.M. Numerical simulation of electrokinetic injection techniques in capillary electrophoresis microchips. Electrophoresis 2005, 26, 674-686.
25. Tsai, C.H.; Wang, Y.N.; Lin, C.F.; Yang, R.J.; Fu, L.M. Experimental and numerical analysis of leakage effect for injectors in microfluidic device. Electrophoresis 2006, 27, 4991-4998.
26. Chang, C.L.; Hou, H.H.; Fu, L.M.; Tsai, C.H. A low-leakage sample plug injection scheme for cross-form microfluidic CE devices incorporating a restricted cross-channel intersection. Electrophoresis 2008, 29, 3135-3144.
27. Zhuang, G.S.; Li, G.; Jin, Q.H.; Zhao, J.L.; Yang, M.S. Numerical analysis of an electrokinetic double-focusing injection technique for microchip CE. Electrophoresis 2006, 27, 5009-5019.
28. Yang, R.J.; Fu, L.M.; Lee, G.B. Variable-volume-injection methods using electrokinetic focusing on microfluidic chips. J. Sep. Sci. 2002, 25, 996-1010.
29. Fu, L.M.; Yang, R.J.; Lee, G.B. Electrokinetic focusing injection methods on microfluidic devices. Anal. Chem. 2003, 75, 1905-1910.
30. Luo, Y.; Wu, D.; Zeng, S.; Gai, H.; Long, Z.; Shen, Z.; Dai, Z.; Qin, J.; Lin, B. Double-cross hydrostatic pressure sample injection for chip CE: Variable sample plug volume and minimum number of electrodes. Anal. Chem. 2006, 78, 6074-6080.
31. Wu, C.H.; Yang, R.J. Improvements on the electrokinetic injection technique for microfluidic chips. Electrophoresis 2006, 27, 4970-4981.
32. Wenclawiak, B.W.; Püschl, R.J. Sample injection for capillary electrophoresis on a micro fabricated device/on chip CE Injection. Anal. Lett. 2006, 39, 3-16.
33. Tsai, C.H.; Hung, M.F.; Chen, L.W.; Chang, C.L.; Fu, L.M. Optimal configuration of CE microchip with expansion chamber in separation channel. J. Chromatogr. A 2006, 1121, 120-128.
34. Fu, L.M.; Leong, J.C.; Lin, C.F.; Tai, C.H.; Tsai, C.H. High performance microfluidic CE devices. Biomed. Microdevices 2007, 9, 405-412.
35. Leong, J.C.; Tsai, C.H.; Fu, L.M. Design of high-resolution analysis technique for capillary electrophoresis microchip. Jap. J. Appl. Phys. 2007, 46, 6865-6870.
36. Hupert, M.L.; Guy, W.J.; Llopis, S.D.; Shadpour, H.; Rani, S.; Nikitopoulos, D.E.; Soper, S.A. Evaluation of micromilled metal mold masters for the replication of microchip electrophoresis devices. Microfluid. Nanofluid. 2007, 3, 1-11.
37. Blas, M.; Delaunay, N.; Rocca, J.L. Comparative study of floating and dynamic injection modes in electrokinetic separative Microsystems. Electrophoresis 2007, 28, 4629-4637.
38. Blas, M.; Delaunay, N.; Rocca, J.L. Electrokinetic-based injection modes for separative microsystems. Electrophoresis 2008, 29, 20-32.
39. Barz, D.P.J. Comprehensive model of electrokinetic flow and migration in microchannels with conductivity gradients. Microfluid. Nanofluid. 2009, 7, 249-265.
40. Li, B.; Jiang, L.; Xie, H.; Gao, Y.; Qin, J.; Lin, B.C. Development of micropump-actuated negative pressure pinched injection for parallel electrophoresis on array microfluidic chip. Electrophoresis 2009, 30, 3053-3057.
41. Bowen, A.L.; Martin, R.S. Integration of on-chip peristaltic pumps and injection valves with microchip electrophoresis and electrochemical detection. Electrophoresis 2010, 31, 2534-2540.
42. Wu, Z.; Cao, X.; Chen, L.; Zhang, J.; Xia, X.; Fang, Q.; Chen, H. Study on the influence of cross-sectional area and zeta potential on separation for hybrid-chip-based capillary electrophoresis using 3-D simulations. Electrophoresis 2010, 31, 3665-3674.
43. Dossi, N.; Toniolo, R.; Susmel, S.; Pizzariello, A.; Bontempelli, G. A simple approach to the hydrodynamic injection in microchip electrophoresis with electrochemical detection. Electrophoresis 2010, 31, 2541-2547.
44. Lee, D.H.; Farouk, B.; Noh, H.S. 3-D simulation of electroosmotic injection and migration in microchannels: effects of non-rectangular cross section. Sep. Sci. Tech. 2011, 46, 195-204.
45. Yang, M.H.; Wang, S.C.; Cheng, J.C. The optimal control of geometry and voltage parameters on electrokinetic transport to avoid sample leakage. Chromatographia 2011, 73, 567-577.
46. Hou, H.H.; Tsai, C.H.; Fu, L.M.; Yang, R.J. Experimental and numerical investigation into micro-flow cytometer with 3-D hydrodynamic focusing effect and microweir structure. Electrophoresis 2009, 30, 2507-2515.
47. Lin, C.; Lee, C.; Tsai, C.; Fu, L. Novel continuous particle sorting in microfluidic chip utilizing cascaded squeeze effect. Microfluid. Nanofluid. 2009, 7, 499-508.
48. Fu, L.M.; Wang, J.H.; Luo, W.B.; Lin, C.H. Experimental and numerical investigation into the joule heating effect for electrokinetically driven microfluidic chips utilizing total internal reflection fluorescence microscopy. Microfluid. Nanofluid. 2009, 6, 499-507.