A general strategy for the synthesis of difluoromethyl-containing pyrazoles, pyridines and pyrimidines

Tetrahedron

Volumn 67, Issue 31, 2011, Pages 5663-5677

  Iaroshenko, Viktor O ^a,b   Specowius, Verena ^a   Vlach, Katharina ^a   Vilches Herrera, Marcelo ^a   Ostrovskyi, Dmytro ^a   Mkrtchyan, Satenik ^a   Villinger, Alexander ^a   Langer, Peter ^a,c  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV   (Ukraine)

^c LEIBNIZ INSTITUT FÜR KATALYSE E V AN DER UNIVERSITÄT ROSTOCK   (Germany)

Author keywords

Cyclizations; N Heterocycles; Organofluorine compounds; Purine isosteres; Regioselectivity

Indexed keywords

1 (4 METHOXYBENZYL) 4 (CHLORODIFLUOROMETHYL) 6 (4 CHLOROPHENYL) 1H PYRROLO[2,3 B]PYRIDINE 3 CARBONITRILE; 1 (4 METHOXYBENZYL) 4 (CHLORODIFLUOROMETHYL) 6 METHYL 1H PYRROLO[2,3 B]PYRIDINE 3 CARBONITRILE; 1 TERT BUTYL 4 (CHLORODIFLUOROMETHYL) 6 (4 CHLOROPHENYL) 1H PYRROLO[2,3 B]PYRIDINE 3 CARBONITRILE; 1 TERT BUTYL 4 (CHLORODIFLUOROMETHYL) 6 (4 METHOXYPHENYL) 1H PYRROLO[2,3 B]PYRIDINE 3 CARBONITRILE; 1 TERT BUTYL 4 (CHLORODIFLUOROMETHYL) 6 METHYL 1H PYRROLO[2,3 B]PYRIDINE 3 CARBONITRILE; 1,3 DICARBONYL COMPOUND; 3 (4 CHLOROBENZYL) 7 (CHLORODIFLUOROMETHYL) 5 METHYL 3H IMIDAZO[4,5 B]PYRIDINE; 3 (4 METHOXYBENZYL) 7 (CHLORODIFLUOROMETHYL) 5 METHYL 3H IMIDAZO[4,5 B]PYRIDINE; 4 (CHLORODIFLUOROMETHYL) 1 CYCLOHEXYL 6 METHYLDS1H PYRROLO[2,3 B]PYRIDINE 3 CARBONITRILE; 4 (CHLORODIFLUOROMETHYL) 3,6 DIMETHYL 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE; 4 (CHLORODIFLUOROMETHYL) 6 (4 CLOROPHENYL) 3 METHYL 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE; 4 (CHLORODIFLUOROMETHYL) 6 (4 METHOXYPHENYL) 3 METHYL 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE; 5 (CHLORODIFLUOROMETHYL) 1,3,7 TRIMETHYLPYRIDO[2,3 D]PYRIMIDINE 2,4(1H,3H) DIONE; 5 (CHLORODIFLUOROMETHYL) 7 (4 CHLOROPHENYL) 1,3 DIMETHYLPYRIDO[2,3 D]PYRIMIDINE 2,4(1H,3H) DIONE; 7 (CHLORODIFLUOROMETHYL) 1,3,5 TRIMETHYL 1H IMIDAZO[4,5 B]PYRIDINE 2(3H) THIONE; 7 (CHLORODIFLUOROMETHYL) 1,5 DIMETHYL 3 PHENYL 1H IMIDAZO[4,5 B]PYRIDINE 2(3H) THIONE; 7 (CHLORODIFLUOROMETHYL) 5 (4 CHLOROPHENYL) N,N DIMETHYLTHIAZOLO[4,5 B]PYRIDIN 2 AMINE; ALLYLTRIMETHYLSTANNANE; AMIDINE; AMINOHETEROCYCLE DERIVATIVE; CARBONYL DERIVATIVE; CHLORODIFLUOROMETHIDE ION; DIFLUOROMETHYL; HETEROCYCLIC COMPOUND; HYDRAZINE DERIVATIVE; METHYL GROUP; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TRIMETHYLSTANNANE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; PRIORITY JOURNAL; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

EID: 79959712001     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2011.05.085     Document Type: Article

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