Synthesis and evaluation of new difluoromethyl azoles as antileishmanial agents

European Journal of Medicinal Chemistry

Volumn 42, Issue 11-12, 2007, Pages 1388-1395

  Ferreira, Sabrina B ^a   Costa, Marilia S ^b   Boechat, Núbia ^c   Bezerra, Rômulo J S ^c   Genestra, Marcelo S ^c   Canto Cavalheiro, Marilene M ^c   Kover, Warner B ^a   Ferreira, Vitor F ^b  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

1,2,3 Triazole; Antileishmanial activity; Difluoromethylation; Imidazole

Indexed keywords

1 (2,6 DIFLUOROPHENYL) 2 METHYL 1H IMIDAZOLE 5 CARBALDEHYDE; 1 (4 BROMOPHENYL) 2 METHYL 1H IMIDAZOLE 5 CARBALDEHYDE; 1 (4 CHLOROPHENYL) 2 METHYL 1H IMIDAZOLE 5 CARBALDEHYDE; 1 (4 FLUOROPHENYL) 2 METHYL 1H IMIDAZOLE 5 CARBALDEHYDE; 1 (4 METHOXYPHENYL) 2 METHYL 1H IMIDAZOLE 5 CARBALDEHYDE; 2 METHYL 1 (4 CYANOPHENYL) 1H IMIDAZOLE 5 CARBALDEHYDE; 2 METHYL 1 (4 NITROPHENYL) 1H IMIDAZOLE 5 CARBALDEHYDE; 2 METHYL 1 4 TOLYL 1H IMIDAZOLE 5 CARBALDEHYDE; 2 METHYL 1 PHENYL 1H IMIDAZOLE 5 CARBALDEHYDE; 2 METHYL 1 [4 (TRIFLUOROMETHYL)PHENYL] 1H IMIDAZOLE 5 CARBALDEHYDE; ALDEHYDE; ANTILEISHMANIAL AGENT; CARBALDEHYDE; DIFLUOROMETHYLAZOLE; DIFLUOROMETHYLENE; IMIDAZOLE; N (2 METHYLPHENYL)ACETAMIDINE; N (2,6 DIFLUOROPHENYL)ACETAMIDINE; N (3 TRIFLUOROMETHYLPHENYL)ACETAMIDINE; N (4 BROMOPHENYL)ACETAMIDINE; N (4 CHLOROPHENYL)ACETAMIDINE; N (4 CYANOPHENYL)ACETAMIDINE; N (4 FLUOROPHENYL)ACETAMIDINE; N (4 METHOXYPHENYL)ACETAMIDINE; N (4 METHYLPHENYL)ACETAMIDINE; N (4 NITROPHENYL)ACETAMIDINE; N (4 TRIFLUOROMETHYLPHENYL)ACETAMIDINE; N PHENYLACETAMIDINE; TRIAZOLE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; LEISHMANIA; NONHUMAN; PROMASTIGOTE;

EID: 36248977120     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.02.020     Document Type: Article

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