Apoptosis signal-regulating kinase 1 deficiency accelerates hyperlipidemia-induced atheromatous plaques via suppression of macrophage apoptosis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 31, Issue 7, 2011, Pages 1555-1564

  Yamada, Sohsuke ^a   Ding, Yan ^a   Tanimoto, Akihide ^a,b   Wang, Ke Yong ^a   Guo, Xin ^a   Li, Zhi ^a   Tasaki, Takashi ^a   Nabesima, Atsunori ^a   Murata, Yoshitaka ^c   Shimajiri, Shohei ^a   Kohno, Kimitoshi ^a   Ichijo, Hidenori ^d,e   Sasaguri, Yasuyuki ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c Kyurin Corporation   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

apoptosis; apoptosis signal regulating kinase 1; bone marrow transplantation; hyperlipidemia induced atherosclerosis; macrophages

Indexed keywords

APOLIPOPROTEIN E; APOPTOSIS SIGNAL REGULATING KINASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; APOPTOSIS SIGNAL REGULATING KINASE 1 DEFICIENCY; ARTICLE; ATHEROSCLEROTIC PLAQUE; BONE MARROW TRANSPLANTATION; CHOLESTEROL DIET; CONTROLLED STUDY; ELASTOLYSIS; GENE INACTIVATION; HYPERLIPIDEMIA; MACROPHAGE; MALE; MOUSE; NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; WILD TYPE;

ANIMALS; AORTA; APOLIPOPROTEINS E; APOPTOSIS; BODY WEIGHT; BONE MARROW TRANSPLANTATION; CHOLESTEROL, DIETARY; DISEASE MODELS, ANIMAL; ELASTIC TISSUE; FOAM CELLS; HYPERLIPIDEMIAS; IMMUNOHISTOCHEMISTRY; LIPOPROTEINS; MACROPHAGES, PERITONEAL; MALE; MAP KINASE KINASE KINASE 5; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NECROSIS; PLAQUE, ATHEROSCLEROTIC; SIGNAL TRANSDUCTION;

EID: 79959692320     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.227140     Document Type: Article

References (31)

1. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999;340:115-126.
2. Lusis AJ. Atherosclerosis. Nature. 2000;407:233-241.
3. Ball RY, Stowers EC, Burton JH, Cary NR, Skepper JN, Mitchinson MJ. Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma. Atherosclerosis. 1995;114:45-54.
4. Schrijvers DM, De Meyer GR, Herman AG, Martinet W. Phagocytosis in atherosclerosis: molecular mechanisms and implications for plaque progression and stability. Cardiovasc Res. 2007;73:470-480. (Pubitemid 46073944)
5. Seimon T, Tabas I. Mechanisms and consequences of macrophage apoptosis in atherosclerosis. J Lipid Res. 2009;50: S382-S387.
6. Liu J, Thewke DP, Su YR, Linton MF, Fazio S, Sinensky MS. Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice. Arterioscler Thromb Vasc Biol. 2005;25:174-179. (Pubitemid 40054272)
7. van Vlijmen BJ, Gerristen G, Franken AL, Boesten LS, Kockx MM, Gijbels MJ, Vierboom MP, van Eck M, van de Water B, van Berkel TJ, Haveskes LM. Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE*3-Leiden transgenic mice. Circ Res. 2001;88:780-786. (Pubitemid 32429973)
8. Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T. A role for the apoptosis inhibitory factor AIM/ Spα/Api6 in atherosclerosis development. Cell Metab. 2005;1: 201-213. (Pubitemid 43960602)
9. Feng B, Zhang D, Kuriakose G, Devlin CM, Kockx M, Tabas I. Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis. Proc Natl Acad Sci USA. 2003;100: 10423-10428. (Pubitemid 37071894)
10. Lim WS, Timmins JM, Seimon TA, Sadler A, Kolodgie FD, Virmani R, Tabas I. Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo. Circulation. 2008; 117:940-951. (Pubitemid 351272592)
11. Kockx MM, Herman AG. Apoptosis in atherosclerosis: beneficial or detrimental? Cardiovasc Res. 2000;45:736-746. (Pubitemid 30047141)
12. Linton MF, Fazio S. Macrophages, inflammation, and atherosclerosis. Int J Obes. 2003;27:S35-S40. (Pubitemid 38019186)
13. Ichijo H, Nishida E, Irie K, Digike PT, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K, Gotoh Y. Induction of apoptosis by ASK1, mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science. 1997;275: 90-94. (Pubitemid 27020316)
14. Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K, Minowa O, Miyazono K, Noda T, Ichijo H. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep. 2001;2:222-228. (Pubitemid 32273301)
15. Watanabe T, Otsu K, Takeda T, Yamaguchi O, Hikoso S, Kashiwase K, Higuchi Y, Taniike M, Nakai A, Matsumura Y, Nishida K, Ichijo H, Hori M. Apoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death. Biochem Biophys Res Commun. 2005;333: 562-567. (Pubitemid 40848328)
16. Izumiya Y, Kim S, Izumi Y, Yoshida K, Yoshiyama M, Matsuzawa A, Ichijo H, Iwao H. Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling. Circ Res. 2003;93:874-883. (Pubitemid 37363062)
17. Yamaguchi O, Higuchi Y, Hirotani S, Kashiwase K, Nakayama H, Hikoso S, Takeda T, Watanabe T, Asahi M, Taniike M, Matsumura Y, Tsujimoto I, Hongo K, Kusakari Y, Kurihara S, Nishida K, Ichijo H, Hori M, Otsu K. Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling. Proc Natl Acad Sci USA. 2003;100: 15883-15888. (Pubitemid 38021084)
18. Liu Q, Sargent MA, York AJ, Molkentin JD. ASK1 regulates cardiomyocyte death but not hypertrophy in transgenic mice. Circ Res. 2009;105:1110-1117.
19. Wang KY, Tanimoto A, Guo X, Yamada S, Shimajiri S, Murata Y, Ding Y, Tsutsui T, Kato S, Watanabe T, Ohtsu H, Hirano KI, Kohno K, Sasaguri Y. Histamine deficiency decrease atherosclerosis and inflammatory response in apolipoprotein E knockout mice independently of serum cholesterol level. Arterioscler Thromb Vasc Biol. 2011;31: 800-807.
20. Sasaguri Y, Wang KY, Tanimoto A, Tsutsui M, Ueno H, Murata Y, Kohno Y, Yamada S, Ohtsu H. Role of histamine produced by bone marrow-derived vascular cells in pathogenesis of atherosclerosis. Circ Res. 2005;96:974-981. (Pubitemid 40712797)
21. Yamada S, Wang KY, Tanimoto A, Fan J, Shimajiri S, Kitajima S, Morimoto M, Tsutui M, Watanabe T, Yasumoto K, Sasaguri Y. Matrix metalloproteinase 12 accelerates the initiation of atherosclerosis and stimulates the progression of fatty streaks to fibrous plaques in transgenic rabbits. Am J Pathol. 2008;172: 1419-1429. (Pubitemid 351671554)
22. Ding Y, Yamada S, Wang KY, Shimajiri S, Guo X, Tanimoto A, Murata Y, Kitajima S, Watanabe T, Izumi H, Kohno K, Sasaguri Y. Overexpression of peroxiredoxin 4 protects against high-dose streptozotocin-induced diabetes by suppressing oxidative stress and cytokines in transgenic mice. Antioxid Redox Signal. 2010; 13:1477-1490.
23. Wang KY, Tanimoto A, Yamada S, Guo X, Murata Y, Ding Y, Watanabe TE, Watanabe TA, Hirano KI, Tukada H, Sasaguri Y. Histamine regulation in glucose and lipid metabolism via histamine receptors. Model for nonalcoholic steatohepatitis in mice. Am J Pathol. 2010;177:713-723.
24. Watanabe H, Bannai S. Induction of cystine transport activity in mouse peritoneal macrophages. J Exp Med. 1987;165: 628-640. (Pubitemid 17059441)
25. Feng B, Yao PM, Li Y, Devlin CM, Zhang D, Harding HP, Sweeney M, Rong JX, Kuriaose G, Fisher EA, Marks AR, Ron D, Tabas I. The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nature Cell Biol. 2003; 9:781-792. (Pubitemid 37087166)
26. Yamamoto K, Ichijo H, Korsmeyer SJ. BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G2M. Mol Cell Biol. 1999;19: 8469-8478. (Pubitemid 30414041)
27. Whitmarsh AJ, Davis RJ. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathway. J Mol Med. 1996;74:589-607. (Pubitemid 26343761)
28. Eberhardt W, Huwiler A, Beck KF, Walpen S, Pfeilschifter J. Amplification of IL-1β-induced matrix metalloproteinase-9 expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-κB and activating protein-1 and involves activation of the mitogen-activated protein kinase pathways. J Immunol. 2000;165:5788-5797.
29. Wu L, Tanimoto A, Murata Y, Fan J, Sasaguri Y, Watanabe T. Induction of human matrix metalloproteinase-12 gene transcriptional activity by GM-CSF requires the AP-1 binding site in human U937 monocytic cells. Biochem Biophys Res Commun. 2001;285:300-307. (Pubitemid 32918070)
30. Wu L, Tanimoto A, Murata Y, Sasaguri T, Fan J, Sasaguri Y, Watanabe T. Matrix metalloproteinase-12 gene expression in human vascular smooth muscle cells. Genes Cells. 2003;8: 225-234. (Pubitemid 36511704)
31. Muniyappa H, Das KC. Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitor SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism. Cell Signal. 2008;20:675-683.