A protective effect of GLY272SER polymorphism of GNB3 gene in development of essential hypertension and its relations with environmental hypertension risk factors

Terapevticheskii Arkhiv

Volumn 83, Issue 4, 2011, Pages 55-60

  Polonikov, A V ^a   Solodilova, M A ^a   Ivanov, V P ^a   Shestakov, A M ^b   Ushachev, D V ^b   Vyalykh, E K ^b   Vasilyeva, O V ^a   Polyakova, N V ^a   Antsupov, V V ^a   Kabanina, V A ^a   Kupriyanova, Ya S ^a   Bulgakova, I V ^a   Kozhukhov, M A ^b   Tevs, D S ^b  

^a State Medical University   (Russian Federation)

^b Regional Hospital   (Russian Federation)

Author keywords

Association analysis; Essential hypertension; Genetic polymorphism; Genotype environment relations; Gnb3 gene; Hereditary predisposition; Risk factors

Indexed keywords

DNA; G PROTEIN BETA3 SUBUNIT; G-PROTEIN BETA3 SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN SUBUNIT;

ALLELE; ARTICLE; BLOOD PRESSURE; COMPARATIVE STUDY; ENVIRONMENTAL EXPOSURE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; HYPERTENSION; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; RISK FACTOR; RUSSIAN FEDERATION;

ALLELES; BLOOD PRESSURE; DNA; ENVIRONMENTAL EXPOSURE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROTEIN SUBUNITS; RISK FACTORS; RUSSIA;

EID: 79959687274     PISSN: 00403660     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Kearney P. M., Whelton M., Reynolds K. et al. Global burden of hypertension: analysis of worldwide data. Lancet 2005; 365 (9455): 217-223. (Pubitemid 40138015)
2. Rossier B. C., Shild L. Epithelial sodium channel. Mendelian versus essential hypertension. Hypertension 2008; 52 (4): 595-600.
3. Orlov S. N., Postnov I. Y., Pokudin N. I. et al. Na+/H+ exchange and other ion transport systems in erythrocytes of essential hypertensives and spontaneously hypertensive rats: a comparative analysis. J. Hypertens. 1989; 7 (10): 781-788. (Pubitemid 19281811)
4. + exchanger with renal Na+ retention in patients with essential hypertension. Am. J. Hypertens. 1995; 8 (2): 124-132.
5. Frolich O., Karmazyn M. The Na-H exchanger revisited: an update on Na-H exchange regulation and the role of the exchanger in hypertension and cardiac function in health and disease. Cardiovasc. Res. 1997; 36 (2): 138-148.
6. Rosskopf D., Dusing R., Siffert W. Membrane sodium-proton exchange and primary hypertension. Hypertension 1993; 21 (2): 607-617. (Pubitemid 23120214)
7. Schunkert H., Hense H. W., Doring A. et al. Association between a polymorphism in the G protein b3 subunit gene and lower renin and elevated diastolic blood pressure levels. Hypertension 1998; 32 (3): 510-513. (Pubitemid 28429141)
8. Neves S. R., Ram P. T., Iyengar R. G protein pathways. Science 2002; 296 (5573): 1636-1639. (Pubitemid 34579147)
9. Rosskopf D., Koch K., Habich C. et al. Interaction of Gbeta 3s, a splice variant of the G-protein Gbeta3, with Ggamma- and Galpha-proteins. Cell. Signal. 2003; 15 (5): 479-488.
10. Wettschureck N., Offermanns S. Mammalian G proteins and their cell type specific functions. Physiol. Rev. 2005; 85 (4): 1159-1204.
11. Levine M. A., Modi W. S., O'Brien S. J. Chromosomal localization of the genes encoding two forms of the G-protein beta polypeptide, beta-1 and beta-3 in man. Genomics 1990; 8 (2): 380-386. (Pubitemid 20335632)
12. Siffert W., Rosskopf D., Siffert G. et al. Association of a human G-protein beta3 subunit variant with hypertension. Nat. Genet. 1998; 18 (1): 45-48.
13. Benjafleld A. V., Jeyasingam C. L., Nyholt D. R. et al. G-protein b3 subunit gene (GNB3) variant in causation of essential hypertension. Hypertension 1998; 32 (6): 1094-1097. (Pubitemid 29001443)
14. Hengstenberg C., Schunkert H., Mayer B. et al. Association between a polymorphism in the G protein beta3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction. Cardiovasc. Res. 2001; 49 (4): 820-827.
15. Dong Y., Zhu H., Sagnella G. A. et al. Association between the C825T polymorphism of the G protein b3-subunit gene and hypertension in blacks. Hypertension 1999; 34 (6): 1193-1196. (Pubitemid 30002381)
16. Brand E., Herrmann S. M., Nicaud V. et al. The 825C/T polymorphism of the G-protein subunit beta3 is not related to hypertension. Hypertension 1999; 33 (5): 1175-1178. (Pubitemid 29230969)
17. Ishikawa K., Imai Y., Katsuya T. et al. Human G-protein beta3 subunit variant is associated with serum potassium and total cholesterol levels but not with blood pressure. Am. J. Hypertens. 2000; 13 (2): 140-145.
18. Tsai C. H., Yeh H. I., Chou Y. et al. G protein beta3 subunit variant and essential hypertension in Taiwan - a case-control study. Int. J. Cardiol. 2000; 73 (2): 191-195.
19. Sartori M., Semplicini A., Siffert W. et al. G-protein beta3-subunit gene 825T allele and hypertension: a longitudinal study in young grade I hypertensives. Hypertension 2003; 42 (5): 909-914. (Pubitemid 37413729)
20. Renner W., Hoffman M. M., Grunbacher G. et al. G-protein beta3 subunit (GNB3) gene polymorphisms and cardiovascular disease: The Ludwigshafen Risk and Cardiovascular Health (LURIC) Study. Atherosclerosis 2007; 192 (1): 108-112. (Pubitemid 46628809)
21. Zeltner R., Delles C., Schneider M. et al. G-protein β3 subunit gene (GNB3) 825T allele is associated with enhanced renal perfusion in early hypertension. Hypertension 2001; 37 (3): 882.
22. Siffert W., Forster P., Jōckei K. H. et al. Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J. Am. Soc. Nephrol. 1999; 10 (9): 1921-1930. (Pubitemid 29402513)
23. Rosskopf D., Manthey I., Siffert W. Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit. Pharmacogenetics 2002; 12 (3): 209-220. (Pubitemid 34596785)
24. Rosskopf D., Busch S, Manthey I., Siffert W. G protein beta 3 gene: structure, promoter, and additional polymorphisms. Hypertension 2000; 36 (1): 33-41. (Pubitemid 30602149)
25. Koch W. J., Hawes B. E., Allen L. F., Lejkowitz R. J. Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21 ras. Proa Natl. Acad. Sci. USA. 1994; 91 (26): 12706-12710.
26. Poch E., Gonzales D., Gomez-Angelats E. et al. G-protein ß3 subunit variant and left ventricular hypertrophy in essential hypertension. Hypertension 2000; 35 (1, pt 2): 214-218. (Pubitemid 30054175)
27. Bagos P. G., Elefiinioti A. L., Nikolopoulos G. K. et al. The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14,094 cases and 17, 760 controls. J. Hypertens. 2007; 25 (3): 487-500. (Pubitemid 46213782)
28. Nefedova Y., Zukova A., Vinnlk T. et al. Angiotension-adducin gene-gene interaction in hypertension development. Atherosclerosis 1999; 144 (suppl.): 73.
29. Siffert W. G protein polymorphisms in hypertension, atherosclerosis, and diabetes. Annu. Rev. Med. 2005; 56 (1): 17-28.
30. Morris A. J., Malbon C. C. Physiological regulation of G protein-linked signaling. Physiol. Rev. 1999; 79 (4): 1373-1430.
31. Siffert W., Rosskopf D., Moritz A. et al. Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension. J. Clin. Invest. 1995; 96 (2): 759-766.
32. Pietruck F., Moritz A., Montemurro M. et al. Selectively enhanced cellular signaling by Gi proteins in essential hypertension. G alpha i2, G alpha i3, G beta 1, and G beta 2 are not mutated. Circ. Res. 1996; 79 (5): 974-983.