4-pyridone-3-carboxamide-1-β-d-ribonucleoside triphosphate (4PyTP), a novel NAD+ metabolite accumulating in erythrocytes of uremic children: A biomarker for a toxic NAD+ analogue in other tissues?

Toxins

Volumn 3, Issue 6, 2011, Pages 520-537

  Synesiou, Elena ^a   Fairbanks, Lynnette D ^b   Simmonds, Anne H ^b   Slominska, Ewa M ^c   Smolenski, Ryszard T ^c   Carrey, Elizabeth A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

4 pyridone 3 5 carboxamide ribonucleoside triphosphate (4PyTP); Erythrocytes; HPLC; IMP dehydrogenase; NAD+; Nicotinamide riboside (NR); Pyridone; Uremia

Indexed keywords

1 METHYLNICOTINAMIDE; 4 PYRIDONE 3 CARBOXAMIDE 1 BETA DEXTRO RIBONUCLEOSIDE TRIPHOSPHATE; ADENOSINE DERIVATIVE; BENZAMIDE; BIOLOGICAL MARKER; CREATININE; GUANOSINE TRIPHOSPHATE; INOSINATE DEHYDROGENASE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; N1 METHYL 2 PYRIDONE CARBOXAMIDE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE RIBOSIDE; PYRIDONE DERIVATIVE; RIBAVIRIN; TIAZOFURIN; TRYPTOPHAN; UNCLASSIFIED DRUG; UREA; URIC ACID;

ADOLESCENT; ARTICLE; BINDING AFFINITY; BLOOD SAMPLING; CHILD; CHRONIC KIDNEY FAILURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE SEVERITY; DRUG BLOOD LEVEL; ENZYME ACTIVITY; ENZYME INHIBITION; ERYTHROCYTE LEVEL; FEMALE; GLOMERULUS FILTRATION RATE; HEMODIALYSIS PATIENT; HUMAN; HUMAN CELL; KIDNEY FUNCTION; LYMPHOCYTE; MALE; METABOLITE; PERITONEAL DIALYSIS; SCHOOL CHILD; TISSUE DISTRIBUTION; TOXIN ANALYSIS; TOXIN STRUCTURE; UREMIA;

ADOLESCENT; BIOLOGICAL MARKERS; CHILD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ERYTHROCYTES; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MASS SPECTROMETRY; NAD; NUCLEOTIDES; RENAL DIALYSIS; SEVERITY OF ILLNESS INDEX; UREMIA;

EID: 79959677359     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins3060520     Document Type: Article

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