An unusual pyridine nucleotide accumulating in erythrocytes: Its identity and positive correlation with degree of renal failure

Nucleosides, Nucleotides and Nucleic Acids

Volumn 23, Issue 8-9, 2004, Pages 1135-1139

  Carrey, E A ^a   Smolenski, R T ^c   Edbury, S M ^b   Laurence, A ^d   Marinaki, A M ^b   Duley, J A ^b   Zhu, L M ^e   Goldsmith, D J A ^b   Simmonds, H A ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GUY S HOSPITAL   (United Kingdom)

^c MEDICAL UNIVERSITY OF GDANSK   (Poland)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e LONDON METROPOLITAN UNIVERSITY   (United Kingdom)

Author keywords

HPLC; LC MS.; N1 methyl 2 pyridone 5 carboxamide (Me2Py); Pyridine Nucleotide; Uraemia

Indexed keywords

1 METHYL 6 OXONICOTINAMIDE; 2 PYRIDONE DERIVATIVE; AMIDE; NICOTINAMIDE; PYRIDINE NUCLEOTIDE; UNCLASSIFIED DRUG;

BLOOD SAMPLING; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE SEVERITY; DRUG UPTAKE; ERYTHROCYTE MEMBRANE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; KIDNEY FAILURE; KIDNEY FUNCTION; METHYLATION; NUCLEAR MAGNETIC RESONANCE; OUTPATIENT; UREMIA;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; ERYTHROCYTES; HUMANS; KIDNEY; KIDNEY FAILURE; MASS SPECTROMETRY; NIACINAMIDE; NUCLEOTIDES; PYRIDINES; PYRIMIDINE NUCLEOTIDES; TIME FACTORS; ULTRAVIOLET RAYS; UREMIA;

EID: 10344223514     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-200027391     Document Type: Conference Paper

References (6)

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2. Slominska, E.M.; Smolenski, R.T.; Szolkiewicz, M.; Leaver, N.; Rutkowski, B.; Simmonds, H.A.; Swierczynski, J. Accumulation of plasma N-methyl-2-pyridone-5-carboxamide in patients with chronic renal failure. Mol. Cell. Biochem. 2002, 237, 83-88.
3. Holman, W.I.M.; Wiegand, C. The chemical conversion of nicotinic acid and nicotinamide to derivatives of N-methyl-2-pyridone by methylation and oxidation. Biochem. J. 1948, 43, 423-426.
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5. Jaecken, J.; Van den Berghe, G. An infantile autistic syndrome characterised by the presence of succinyl purines in body fluids. The Lancet 1984, 2, 1058-1061.
6. Carrey, E.A.; Smolenski, R.T.; Edbury, S.M.; Laurence, A.; Marinaki, A.M.; Duley, J.A.; Zhu, L.M.; Goldsmith, D.A.; Simmonds, H.A. Origin and characteristics of an unusual pyridine nucleotide accumulating in erythrocytes: positive correlation with degree of renal failure. Clin. Chim. Acta 2003, 335, 117-129.