Conformational changes and stabilization of inosine 5'monophosphate dehydrogenase associated with ligand binding and inhibition by mycophenolic acid

Journal of Biological Chemistry

Volumn 271, Issue 32, 1996, Pages 19421-19427

  Nimmesgern, Elmar ^a   Fox, Ted ^a   Fleming, Mark A ^a   Thomson, John A ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INOSINATE DEHYDROGENASE; INOSINE PHOSPHATE; MYCOPHENOLIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ARTICLE; CATALYSIS; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; ENZYME DEGRADATION; ENZYME DENATURATION; ENZYME INHIBITOR COMPLEX; ENZYME STABILITY; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL;

ANILINO NAPHTHALENESULFONATES; ANIMALS; CIRCULAR DICHROISM; CRICETINAE; ENZYME INHIBITORS; ENZYME STABILITY; FLUORESCENCE; FLUORESCENT DYES; HYDROLYSIS; IMP DEHYDROGENASE; MYCOPHENOLIC ACID; PANCREATIC ELASTASE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION; UREA;

CRICETINAE; ESCHERICHIA COLI;

EID: 0029741196     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.32.19421     Document Type: Article

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