Priming with a combination of proangiogenic growth factors enhances wound healing in streptozotocin-induced diabetes in mice

European Surgical Research

Volumn 47, Issue 2, 2011, Pages 81-89

  Ackermann, Maximilian ^a   Wolloscheck, Tanja ^a   Wellmann, Axel ^b   Li, Vincent W ^c,d   Li, William W ^d   Konerding, Moritz A ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b Institute of Pathology Celle   (Germany)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d The Angiogenesis Foundation   (United States)

Author keywords

bFGF; Infrared thermography; PDGF; Proangiogenic growth factors; Streptozotocin induced diabetes; Tensile strength; VEGF

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; STREPTOZOCIN; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; MORPHOLOGY; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PUNCH BIOPSY; TISSUE REPAIR; WOUND CLOSURE; WOUND HEALING;

ANGIOGENIC PROTEINS; ANIMALS; COLLAGEN; DIABETES COMPLICATIONS; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; FIBROBLAST GROWTH FACTOR 2; MICE; MICE, INBRED BALB C; NEOVASCULARIZATION, PHYSIOLOGIC; PLATELET-DERIVED GROWTH FACTOR; SKIN; SKIN TEMPERATURE; TENSILE STRENGTH; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 79959674924     PISSN: 0014312X     EISSN: 14219921     Source Type: Journal    
DOI: 10.1159/000328143     Document Type: Article

References (33)

1. Brem H, Tomic-Canic M: Cellular and molecular basis of wound healing in diabetes. J Clin Invest 2007; 117: 1219-1222. (Pubitemid 46718408)
2. Galiano RD, Tepper OM, Pelo CR, Bhatt KA, Callaghan M, Bastidas N, Bunting S, Steinmetz HG, Gurtner GC: Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Am J Pathol 2004; 164: 1935-1947. (Pubitemid 38669343)
3. Singer AJ, Clark RA: Cutaneous wound healing. N Engl J Med 1999; 341: 738-746. (Pubitemid 29407375)
4. Risau W: Mechanisms of angiogenesis. Nature 1997; 386: 671-674. (Pubitemid 27193480)
5. Witte MB, Kiyama T, Barbul A: Nitric oxide enhances experimental wound healing in diabetes. Br J Surg 2002; 89: 1594-1601. (Pubitemid 35404331)
6. Chan RK, Liu PH, Pietramaggiori G, Ibrahim SI, Hechtman HB, Orgill DP: Effect of recombinant platelet-derived growth factor (Regranex) on wound closure in genetically diabetic mice. J Burn Care Res 2006; 27: 202-205. (Pubitemid 43970323)
7. Ackermann M, Wolloscheck T, Wellmann A, Li VW, Li WW, Konerding MA: Priming with a combination of proangiogenic growth factors improves wound healing in normoglycemic mice. Int J Mol Med 2011; 27: 647-653.
8. Giunta RE, Holzbach T, Taskov C, Holm PS, Konerding MA, Schams D, Biemer E, Gänsbacher B: AdVEGF165 gene transfer increases survival in overdimensioned skin flaps. J Gene Med 2005; 7: 297-306. (Pubitemid 40443758)
9. Lenzen S: The mechanisms of alloxan-and streptozotocin-induced diabetes. Diabetologia 2008; 51: 216-226.
10. FDA Wound Healing Clinical Focus Group: Guidance for industry: Chronic cutaneous ulcer and burn wounds -developing products for treatment. Wound Repair Regen 2001; 9: 258-268.
11. Junqueira LC, Bignolas G, Brentani RR: Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J 1979; 11: 447-455. (Pubitemid 9238595)
12. Weibel ER, Kistler GS, Scherle WF: Practical stereological methods for morphometric cytology. J Cell Biol 1966; 30: 23-38.
13. Keswani SG, Katz AB, Lim FY, Zoltick P, Radu A, Alaee D, Herlyn M, Crombleholme TM: Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type I and type II diabetic wounds. Wound Repair Regen 2004; 12: 497-504. (Pubitemid 39314331)
14. Bauer SM, Bauer RJ, Velazquez OC: Angiogenesis, vasculogenesis, and induction of healing in chronic wounds. Vasc Endovascular Surg 2005; 39: 293-306. (Pubitemid 41061696)
15. Hanft JR, Pollak RA, Barbul A, van Gils C, Kwon PS, Gray SM, Lynch CJ, Semba CP, Breen TJ: Phase I trial on the safety of topical rhVEGF on chronic neuropathic diabetic foot ulcers. J Wound Care 2008; 17: 30-32, 34-37.
16. Richard JL, Parer-Richard C, Daures JP, Clouet S, Vannereau D, Bringer J, Rodier M, Jacob C, Comte-Bardonnet M: Effect of topical basic fibroblast growth factor on the healing of chronic diabetic neuropathic ulcer of the foot. A pilot, randomized, doubleblind, placebo-controlled study. Diabetes Care 1995; 18: 64-69.
17. Raja, Sivamani K, Garcia MS, Isseroff RR: Wound re-epithelialization: Modulating keratinocyte migration in wound healing. Front Biosci 2007; 12: 2849-2868.
18. Brem H, Kodra A, Golinko MS, Entero H, Stojadinovic O, Wang VM, Sheahan CM, Weinberg AD, Woo SL, Ehrlich HP, Tomic-Canic M: Mechanism of sustained release of vascular endothelial growth factor in accelerating experimental diabetic healing. J Invest Dermatol 2009; 129: 2275-2287.
19. Kilarski WW, Samolov B, Petersson L, Kvanta A, Gerwins P: Biomechanical regulation of blood vessel growth during tissue vascularization. Nat Med 2009; 15: 657-664.
20. Corral CJ, Siddiqui A, Wu L, Farrell CL, Lyons D, Mustoe TA: Vascular endothelial growth factor is more important than basic fibroblastic growth factor during ischemic wound healing. Arch Surg 1999; 134: 200-205. (Pubitemid 29088975)
21. Dudar TE, Jain RK: Microcirculatory flow changes during tissue growth. Microvasc Res 1983; 25: 1-21. (Pubitemid 13189297)
22. Hashimoto H, Prewitt RL: Microvascular density changes during wound-healing. Int J Microcirc Clin Exp 1987; 5: 303-310.
23. Kilarski WW, Gerwins P: A new mechanism of blood vessel growth -hope for new treatment strategies. Discov Med 2009; 8: 23-27.
24. Ausprunk DH, Folkman J: Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res 1977; 14: 53-65. (Pubitemid 8153798)
25. Brown NJ, Smyth EA, Cross SS, Reed MW: Angiogenesis induction and regression in human surgical wounds. Wound Repair Regen 2002; 10: 245-251. (Pubitemid 35006786)
26. Greenhalgh DG: The role of apoptosis in wound healing. Int J Biochem Cell Biol 1998; 30: 1019-1030. (Pubitemid 28484857)
27. Arroyo AG, Iruela-Arispe ML: Extracellular matrix, inflammation, and the angiogenic response. Cardiovasc Res 2010; 86: 226-235.
28. Endrich B, Menger MD: Regeneration der Mikrozirkulation während der Wundheilunĝ Unfallchirurg 2000 Nov;103: 1006-1018.
29. Semenza GL: Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1. Exp Physiol 2007; 92: 988-991. (Pubitemid 47568844)
30. Bao P, Kodra A, Tomic-Canic M, Golinko MS, Ehrlich HP, Brem H: The role of vascular endothelial growth factor in wound healing. J Surg Res 2009; 153: 347-358.
31. Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M: Growth factors and cytokines in wound healing. Wound Repair Regen 2008; 16: 585-601.
32. Li J, Zhang YP, Kirsner RS: Angiogenesis in wound repair: Angiogenic growth factors and the extracellular matrix. Microsc Res Tech 2003; 60: 107-114. (Pubitemid 36055239)
33. Tonnesen MG, Feng X, Clark RA: Angiogenesis in wound healing. J Investig Dermatol Symp Proc 2000; 5: 40-46. (Pubitemid 32044088)