The prognostic value of p53 mutation in pediatric marrow hypoplasia

Diagnostic Pathology

Volumn 6, Issue 1, 2011, Pages

  Abo Elwafa, Hasnaa A ^a   Attia, Fadia M ^b   Sharaf, Alzahraa E A ^a  

^a Sohag University   (Egypt)

^b Suez Canal University Faculty of Medicine   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

DIAGNOSTIC AGENT; MITOMYCIN;

ADOLESCENT; APLASTIC ANEMIA; ARTICLE; AUTOIMMUNE DISEASE; BONE MARROW CELL; CHILD; CHROMOSOME BREAKAGE; FANCONI ANEMIA; FEMALE; GENETICS; HUMAN; HUMAN CHROMOSOME; IMMUNOLOGY; MALE; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PRESCHOOL CHILD; PROGNOSIS; THROMBOCYTOPENIA; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ANEMIA, APLASTIC; AUTOIMMUNE DISEASES; BONE MARROW CELLS; CHILD; CHILD, PRESCHOOL; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN; DNA MUTATIONAL ANALYSIS; FANCONI ANEMIA; FEMALE; GENES, P53; HUMANS; MALE; MITOMYCIN; MUTATION; PROGNOSIS; THROMBOCYTOPENIA;

EID: 79959663428     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-6-58     Document Type: Article

References (21)

1. Al-Rahawn MM, Alter BP, Bryant BJ, Elghetany MT. Bone marrow cell cycle markers in inherited bone marrow failure syndromes. Leuk Res 2008, 32(12):1793-9. 10.1016/j.leukres.2008.05.020, 2716700, 18606449.
2. Rosenberg PS, Greene MH, Alter BP. Cancer incidence in persons with fanconi anemia. Blood 1 2003, 101(3):822-6.
3. Moldovan G, Andrea ADD. How fanconi anemia pathway guard the genome, National center for biotechnology. Annu Rev Genet 2009, 43:223-249. 10.1146/annurev-genet-102108-134222, 2830711, 19686080.
4. Xue Y, Li Y, Guo R, Ling C, Wang W. FANCM of the Fanconi anemia core complexis required for both monoubiquitination and DNA repair. Hum Mol Genet 2008, 17:1641-52. 10.1093/hmg/ddn054, 2902294, 18285517.
5. Alter BP, Giri N, Savage SA, Rosenberg PS. Cancer in dyskeratosis congenita 25. Blood 2009, 113(26):6549-57. 10.1182/blood-2008-12-192880, 2710915, 19282459.
6. Elghetany MT, Alter BP. p53 protein overexpression in bone marrow biopsies of patients with Shwachman-Diamond syndrome has a prevalence similar to that of patients with refractory anemia. Arch Pathol Lab Med 2002, 126(4):452-5.
7. Anker P, Mulcahy H, Chen XQ, Stroun M. Detection of circulating tumor DNA in the blood (plasma/serum) of cancer patients. Cancer Metastasis Rev 1999, 18:65-73. 10.1023/A:1006260319913, 10505546.
8. Wang W. A major switch for the Fanconi anemia DNA damage-response pathway. Nat Struct Mol Biol 2008, 15:1128-30. 10.1038/nsmb1108-1128, 18985065.
9. Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Hee Park S, Thompson T, Karsenty G, Bradley A, Donehower LA. p53mutant mice that display early ageing-associated phenotypes. Nature 2002, 415(6867):45-53. 10.1038/415045a, 11780111.
10. Ventura A, Kirsch DG, Mclaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T. Restoration of p53 function leads to tumor regression in vivo. Nature 2007, 445(7128):661-5. 10.1038/nature05541, 17251932.
11. Orazi A, Cattoretti G, Heerema NA, Sozzi G, John K, Neiman RS. Frequent p53 over expression in therapy related myelodysplastic syndromes and acute myeloid leukemia: an immunohistochemical study of bone marrow biopsies. Mod Pathol 1993, 6:521-5.
12. Elghetany MT, Vyas S, Yuoh G. Significance of p53 overexpression in bone marrow biopsies from patients with bone marrow failure: aplastic anemia, hypocellular refractory anemia, and hypercellular refractory anemia. Ann Hematol 1998, 77:261-4. 10.1007/s002770050455, 9875662.
13. Frisch B, Lewis M. The bone marrow in aplastic anaemia: Diagnostic and prognostic features. J clin Path 1974, 27:231-41. 10.1136/jcp.27.3.231, 478077, 4832303.
14. Cervenka J, Arthur D, Yasis C. Mitomycin C test for diagnostic differentiation of idiopathic aplastic anemia and Fanconi anemia. Pediatrics 1981, 67(1):119-27.
15. Basset-Seguin N, Molềs JP, Mils V, Dereure O, Guilhou JJ. TP53 tumor suppressor gene and skin carcinogenesis. J Invest Dermatol 1994, 103(5 Suppl):102S-106S.
16. WU X, Bayle JH, Olson D, Levine AJ. The p53-mdm-2 autoregulatory feedback loop. Genes Dev 1993, 7(7A):1126-32. 10.1101/gad.7.7a.1126, 8319905.
17. Chen J, Marechal V, Levine AJ. Mapping of the p53 and mdm-2 interaction domains. Mol Cell Biol 1993, 13:4107-14. 359960, 7686617.
18. Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem 2000, 275:45-8951.
19. Yan J, Jetten AM. RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites. Cancer Lett 2008, 271:179-90. 10.1016/j.canlet.2008.04.046, 2749678, 18550271.
20. Wu Y, Brosh RM. FANCJ helicase operates in the Fanconi Anemia DNA repair pathway and the response to replicational stress. Laboratory of Molecular Gerontology, National Institute on Aging, NIH, NIH Biomedical Research Center, Baltimore, MD 21224, USA 2009, 9(4):470-82.
21. Nabhan SK, Bitencourt M, Duval M, Abecasis M, Dufour C, Boudjedir K, Rocha V, Socié G, Passweg J, Goi K, Sanders J, Snowden J, Yabe H, Pasquini R, Gluckman E. Fertility recovery and pregnancy after allogeneic hematopoietic stem cell transplantation in Fanconi anemia patients. Citation: Hematologica 96:xxx.