Time course of classically conditioned purkinje cell response is determined by initial part of conditioned stimulus

Journal of Neuroscience

Volumn 31, Issue 25, 2011, Pages 9070-9074

  Jirenhed, Dan Anders ^a   Hesslow, Germund ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CONDITIONING; CONTROLLED STUDY; FERRET; LATENT PERIOD; MALE; MOSSY FIBER; NERVE CELL STIMULATION; NERVE CONDUCTION; NERVE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RESPONSE TIME; SIGNAL TRANSDUCTION;

ACTION POTENTIALS; ADAPTATION, PHYSIOLOGICAL; ANIMALS; CONDITIONING, CLASSICAL; EVOKED POTENTIALS, MOTOR; FERRETS; MALE; PURKINJE CELLS;

EID: 79959642757     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1653-11.2011     Document Type: Article

References (21)

1. Bullock D, Fiala JC, Grossberg S (1994) A neural model of timed response learning in the cerebellum. Neural Netw 7:1101-1114.
2. Buonomano DV, Mauk BD (1994) Neural network model of the cerebellum: temporal discrimination and the timing of motor responses. Neural Comput 6:38-55.
3. D'Angelo E, De Zeeuw CI (2009) Timing and plasticity in the cerebellum: focus on the granular layer. Trends Neurosci 32:30-40.
4. Dean P, Porrill J (2008) Adaptive-filter models of the cerebellum: computational analysis. Cerebellum 7:567-571.
5. Desmond JE, Moore JW (1988) Adaptive timing in neural networks: the conditioned response. Biol Cybern 58:405-415.
6. Hesslow G (1994a) Correspondence between climbing fibre input and motor output in eyeblink-related areas in cat cerebellar cortex. J Physiol 476:229-244.
7. Hesslow G (1994b) Inhibition of classically conditioned eyeblink responses by stimulation of the cerebellar cortex in the decerebrate cat. J Physiol 476:245-256.
8. Hesslow G, Ivarsson M (1994) Suppression of cerebellar Purkinje cells during conditioned responses in ferrets. Neuroreport 5:649-652.
9. Hesslow G, Yeo CH (2002) The functional anatomy of skeletal condition- ing. In: A neuroscientist's guide to classical conditioning (Moore JW, ed), pp 86-146. New York: Springer.
10. Ivry RB, Spencer RM (2004) The neural representation of time. Curr Opin Neurobiol 14:225-232.
11. Jirenhed D-A, Hesslow G (2011) Learning stimulus intervals-adaptive timing of conditioned Purkinje cell responses. Cerebellum. Advance online publication. doi:10.1007/s12311-011-0264-3.
12. Jirenhed D-A, Bengtsson F, Hesslow G (2007) Acquisition, extinction, and reacquisition of a cerebellar cortical memory trace. J Neurosci 27:2493-2502.
13. Jörntell H, Ekerot CF (2006) Properties of somatosensory synaptic integration in cerebellar granule cells in vivo. J Neurosci 26:11786-11797.
14. Kalmbach BE, Ohyama T, Kreider JC, Riusech F, Mauk MD (2009) Interactions between prefrontal cortex and cerebellum revealed by trace eyelid conditioning. Learn Mem 16:86-95.
15. Kehoe EJ, Macrae M (2002) Fundamental behavioral methods and findings in classical conditioning. In: A neuroscientist's guide to classical conditioning (Moore JW, ed), pp 171-231. New York: Springer.
16. Mauk MD, Buonomano DV (2004) The neural basis of temporal processing. Annu Rev Neurosci 27:307-340.
17. Svensson P, Ivarsson M (1999) Short-lasting conditioned stimulus applied to the middle cerebellar peduncle elicits delayed conditioned eye blink responses in the decerebrate ferret. Eur J Neurosci 11:4333-4340.
18. Svensson P, Ivarsson M, Hesslow G (1997) Effect of varying the intensity and train frequency of forelimb and cerebellar mossy fiber conditioned stimuli on the latency of conditioned eye-blink responses in decerebrate ferrets. Learn Mem 4:105-115.
19. Svensson P, Jirenhed DA, Bengtsson F, Hesslow G (2010) Effect of conditioned stimulus parameters on timing of conditioned Purkinje cell responses. J Neurophysiol 103:1329-1336.
20. Woody CD, Nahvi A, Palermo G, Wan J, Wang XF, Gruen E (1999) Differences in responses to 70 dB clicks of cerebellar units with simple versus complex spike activity: (i) in medial and lateral ansiform lobes and flocculus; and (ii) before and after conditioning blink conditioned responses with clicks as conditioned stimuli. Neuroscience 90: 1227-1241.
21. Yamazaki T, Tanaka S (2009) Computational models of timing mechanisms in the cerebellar granular layer. Cerebellum 8:423-432.