Learning stimulus intervals - Adaptive timing of conditioned purkinje cell responses

Cerebellum

Volumn 10, Issue 3, 2011, Pages 523-535

  Jirenhed, Dan Anders ^a,b   Hesslow, Germund ^a  

^a LUND UNIVERSITY   (Sweden)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Cerebellum; Classical conditioning; Climbing fibres; Mossy fibres; Purkinje cells; Time

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CEREBELLAR MOSSY FIBER; CLIMBING FIBER; CONTROLLED STUDY; DECEREBRATION; DISCRIMINATION LEARNING; EYELID REFLEX; FERRET; IN VIVO STUDY; INTRACELLULAR RECORDING; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; SENSORY NERVE CELL; STIMULUS RESPONSE; TEMPORAL CORTEX; VISUAL ADAPTATION; VISUAL STIMULATION;

ACTION POTENTIALS; ADAPTATION, PHYSIOLOGICAL; AFFERENT PATHWAYS; ANALYSIS OF VARIANCE; ANIMALS; BLINKING; CEREBELLUM; CONDITIONING, CLASSICAL; ELECTRIC STIMULATION; FERRETS; NERVE FIBERS; REACTION TIME; TIME FACTORS; TIME PERCEPTION;

EID: 80455129226     PISSN: 14734222     EISSN: 14734230     Source Type: Journal    
DOI: 10.1007/s12311-011-0264-3     Document Type: Article

References (35)

1. Kehoe EJ, Macrae M. Fundamental behavioral methods and findings in classical conditioning. In: Moore JW, editor. A neuroscientist's guide to classical conditioning. New York: Springer; 2002. p. 171-231.
2. Mauk MD, Buonomano DV. The neural basis of temporal processing. Annu Rev Neurosci. 2004;27:307-40. (Pubitemid 39050406)
3. Ivry R. Cerebellar timing systems. In: Schmahmann JD, editor. The cerebellum and cognition. New York: Academic; 1997. p. 555-73. (Pubitemid 127826244)
4. Ivry RB, Spencer RM. The neural representation of time. Curr Opin Neurobiol. 2004;14(2):225-32. (Pubitemid 38479941)
5. McCormick DA, Thompson RF. Cerebellum: essential involvement in the classically conditioned eyelid response. Science. 1984;223(4633):296-9. (Pubitemid 14215791)
6. Hesslow G, Yeo CH. The functional anatomy of skeletal conditioning. In: Moore JW, editor. A neuroscientist's guide to classical conditioning. New York: Springer; 2002. p. 86-146.
7. Christian KM, Thompson RF. Neural substrates of eyeblink conditioning: acquisition and retention. Learn Mem. 2003;10 (6):427-55. (Pubitemid 37499774)
8. Thompson RF, Steinmetz JE. The role of the cerebellum in classical conditioning of discrete behavioral responses. Neuroscience. 2009;162(3):732-55.
9. Jirenhed DA, Bengtsson F, Hesslow G. Acquisition, extinction, and reacquisition of a cerebellar cortical memory trace. J Neurosci. 2007;27(10):2493-502. (Pubitemid 46393596)
10. Yeo CH, Hesslow G. Cerebellum and conditioned reflexes. Trends Cogn Sci. 1998;2(9):322-30. (Pubitemid 28396567)
11. Kotani S, Kawahara S, Kirino Y. Purkinje cell activity during learning a new timing in classical eyeblink conditioning. Brain Res. 2003;994(2):193-202. (Pubitemid 37464883)
12. Ekerot CF, Gustavsson P, Oscarsson O, Schouenborg J. Climbing fibres projecting to cat cerebellar anterior lobe activated by cutaneous A and C fibres. J Physiol Lond. 1987;386:529-38. (Pubitemid 17059733)
13. Simpson JI, Wylie DR, De Zeeuw CI. On climbing fiber signals and their consequences. Behav Brain Sci. 1996;19:384-98. (Pubitemid 27121965)
14. Maruta J, Hensbroek RA, Simpson JI. Intraburst and interburst signaling by climbing fibers. J Neurosci. 2007;27(42):11263-70. (Pubitemid 47621313)
15. Hesslow G. Correspondence between climbing fibre input and motor output in eyeblink-related areas in cat cerebellar cortex. J Physiol Lond. 1994;476(2):229-44. (Pubitemid 24129806)
16. Hesslow G. Inhibition of classically conditioned eyeblink responses by stimulation of the cerebellar cortex in the decerebrate cat. J Physiol Lond. 1994;476(2):245-56. (Pubitemid 24129807)
17. Kehoe EJ. Extension of the CS past the US can facilitate conditioning of the rabbit's nictitating membrane response. Behav Processes. 2000;50(2-3):155-64.
18. Gormezano I, Moore JW. Classical conditioning. In: Marx MH, editor. Learning: processes. New York: Macmillan; 1969.
19. Lepora NF, Mavritsaki E, Porrill J, Yeo CH, Evinger C, Dean P. Evidence from retractor bulbi EMG for linearized motor control of conditioned nictitating membrane responses. J Neurophysiol. 2007;98(4):2074-88. (Pubitemid 47584394)
20. Kehoe EJ, Joscelyne A. Temporally specific extinction of conditioned responses in the rabbit (Oryctolagus cuniculus) nictitating membrane preparation. Behav Neurosci. 2005;119:1011-22. (Pubitemid 41377252)
21. Apps R, Garwicz M. Anatomical and physiological foundations of cerebellar information processing.Nat Rev Neurosci. 2005;6:297-311. (Pubitemid 40469984)
22. Kehoe EJ, Ludvig EA, Sutton RS. Timing in trace conditioning of the nictitating membrane response of the rabbit (Oryctolagus cuniculus): scalar, nonscalar, and adaptive features. Learn Mem. 2010;17(12):600-4.
23. Millenson JR, Kehoe EJ, Gormezano I. Classical conditioning of the rabbit's nictitating membrane response under fixed and mixed CS-US intervals. Learn Motiv. 1977;8:351-66.
24. Hoehler FK, Leonard DW. Double responding in classical nictitating membrane conditioning with single-CS dual-ISI training. Pavlov J Biol Sci. 1976;11:180-90.
25. Choi JS, Moore JW. Cerebellar neuronal activity expresses the complex topography of conditioned eyeblink responses. Behav Neurosci. 2003;117(6):1211-9. (Pubitemid 37549423)
26. Yamazaki T, Tanaka S. Computational models of timing mechanisms in the cerebellar granular layer. Cerebellum. 2009;8(4):423-32.
27. Fiala JC, Grossberg S, Bullock D. Metabotropic glutamate receptor activation in cerebellar Purkinje cells as substrate for adaptive timing of the classically conditioned eye-blink response. J Neurosci. 1996;16(11):3760-74. (Pubitemid 26149512)
28. Steuber V, Willshaw D. A biophysical model of synaptic delay learning and temporal pattern recognition in a cerebellar Purkinje cell. J Comput Neurosci. 2004;17:149-64. (Pubitemid 39157970)
29. Desmond JE, Moore JW. Adaptive timing in neural networks: the conditioned response. Biol Cybern. 1988;58(6):405-15.
30. Zipser D. A model of hippocampal learning during classical conditioning. Behav Neurosci. 1986;100(5):764-76. (Pubitemid 17208213)
31. Hesslow G, Svensson P, Ivarsson M. Learned movements elicited by direct stimulation of cerebellar mossy fiber afferents. Neuron. 1999;24(1):179-85. (Pubitemid 29466157)
32. Svensson P, Jirenhed DA, Bengtsson F, Hesslow G. Effect of conditioned stimulus parameters on timing of conditioned Purkinje cell responses. J Neurophysiol. 2010;103(3):1329-36.
33. Medina JF, Mauk MD. Computer simulation of cerebellar information processing. Nat Neurosci. 2000;3:1205-11.
34. Moore JW, Desmond JE, Berthier NE. Adaptively timed conditioned responses and the cerebellum: a neural network approach. Biol Cybern. 1989;62(1):17-28. (Pubitemid 20003988)
35. Jörntell H, Ekerot CF. Properties of somatosensory synaptic integration in cerebellar granule cells in vivo. J Neurosci. 2006;26(45):11786-97. (Pubitemid 44772149)