Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation

Chemistry - A European Journal

Volumn 17, Issue 28, 2011, Pages 7806-7816

  Parker, Lorien J ^a,b   Italiano, Louis C ^a,b   Morton, Craig J ^a   Hancock, Nancy C ^a   Ascher, David B ^a   Aitken, Jade B ^c   Harris, Hugh H ^d   Campomanes, Pablo ^e   Rothlisberger, Ursula ^e   De Luca, Anastasia ^f   Lo Bello, Mario ^f   Ang, Wee Han ^g   Dyson, Paul J ^e   Parker, Michael W ^a,b  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF ADELAIDE   (Australia)

^e EPFL   (Switzerland)

^f UNIVERSITY OF ROME TOR VERGATA   (Italy)

^g NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

antitumor agents; detoxification; ethacrynic acid; glutathione transferases; X ray crystallography

Indexed keywords

ACTIVE SITE; ANTI-TUMOR AGENTS; ANTICANCER COMPOUNDS; CANCER DRUG; CARBOXYLATE COMPLEXES; CHEMOTHERAPEUTIC AGENTS; CIS-PLATIN; COVALENT BINDING; CYTOSOLIC; DIMER INTERFACE; DRUG RESISTANCE; ENZYMATIC ACTIVITIES; ETHACRYNIC ACID; GLUTATHIONE TRANSFERASE; GLUTATHIONE-S-TRANSFERASE; IRREVERSIBLE INHIBITIONS; MAMMALIAN CELLS; MERCAPTURIC ACIDS; MOLECULAR BASIS; MOLECULAR LEVELS; MOLECULAR MODELING ANALYSIS; OVER-EXPRESSION; PLATINUM COMPLEXES; QUANTUM MECHANICAL/MOLECULAR MECHANICAL; SOLID TUMORS;

CARBOXYLATION; DETOXIFICATION; DIMERS; DISEASES; DRUG INTERACTIONS; ENZYME INHIBITION; LIGANDS; MAMMALS; MOLECULAR MODELING; PLATINUM; X RAY CRYSTALLOGRAPHY;

PLATINUM COMPOUNDS;

ANTINEOPLASTIC AGENT; CISPLATIN; ENZYME INHIBITOR; ETACRYNIC ACID; GLUTATHIONE TRANSFERASE P1; PLATINUM; RECOMBINANT PROTEIN;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; GENETICS; HUMAN; METABOLISM; MOLECULAR DYNAMICS; MOLECULAR GENETICS; NEOPLASM; PROTEIN BINDING; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; CISPLATIN; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ENZYME INHIBITORS; ETHACRYNIC ACID; GLUTATHIONE S-TRANSFERASE PI; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NEOPLASMS; PLATINUM; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 79959631948     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201100586     Document Type: Article

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