Radiolabelling of engineered nanoparticles for in vitro and in vivo tracing applications using cyclotron accelerators

Archives of Toxicology

Volumn 85, Issue 7, 2011, Pages 751-773

  Gibson, N ^a   Holzwarth, U ^a   Abbas, K ^a   Simonelli, F ^a   Kozempel, J ^a   Cydzik, I ^a   Cotogno, G ^a   Bulgheroni, A ^a   Gilliland, D ^a   Ponti, J ^a   Franchini, F ^a   Marmorato, P ^a   Stamm, H ^a   Kreyling, W ^b   Wenk, A ^b   Semmler Behnke, M ^b   Buono, S ^c   MacIocco, L ^c   Burgio, N ^d  

^a JOINT RESEARCH CENTRE   (Italy)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c Advanced Accelerator Applications (AAA)   (France)

^d ENEA C R CASACCIA   (Italy)

Author keywords

Ion beam irradiation; Nanoparticles; Neutron irradiation; Radiolabelling; Radiotracer; Toxicity

Indexed keywords

NANOPARTICLE;

AEROSOL; ARTICLE; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; CYCLOTRON; GAMMA SPECTROMETRY; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; NANOENGINEERING; NANOTOXICOLOGY; NEUTRON ACTIVATION ANALYSIS; NEUTRON RADIATION; PHOTOACTIVATION; PRIORITY JOURNAL; RADIATION BEAM; RADIATION INJURY; RADIOCHEMISTRY; SYNTHESIS; THERMAL INJURY;

CYCLOTRONS; ISOTOPE LABELING; METAL NANOPARTICLES; NANOPARTICLES; RADIOACTIVE TRACERS; RADIOISOTOPES; THERMODYNAMICS;

EID: 79959624264     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0701-6     Document Type: Article

References (98)

1. Abanades A, Aleixandre J, Andriamonje S, Angelopoulos A, Apostolakis A, Arnould H, Belle E, Bompas CA, Brozzi D, Bueno J, Buono S, Carminati F, Casagrande F, Cennini P, Collar JI, Cerro E, Moral RD, Dez S, Dumps L, Eleftheriadis C, Embid M, Fernandez R, Galvez J, Garca J, Geles C, Giorni A, Gonzalez E, Gonzalez O, Goulas I, Heuer D, Hussonnois M, Kadi Y, Karaiskos P, Kitis G, Klapisch R, Kokkas P, Lacoste V, Naour CL, Lopez C, Loiseaux JM, Martnez-Val JM, Meplan O, Nifenecker H, Oropesa J, Papadopoulos I, Pavlopoulos P, Perez-Enciso E, Perez-Navarro A, Perlado M, Placci A, Poza M, Revol J-P, Rubbia C, Rubio JA, Sakelliou L, Saldana F, Savvidis E, Schussler F, Sirvent C, Tamarit J, Trubert D, Tzima A, Viano JB, Vieira S, Vlachoudis V, Zioutas K (2002) Results from the TARC experiment: Spallation neutron phenomenology in lead and neutron-driven nuclear transmutation by adiabatic resonance crossing nuclear instruments and methods in physics research, section a: accelerators, spectrometers. Detectors and Associated Equipment 478:577-730 (Pubitemid 34187464)
2. Abbas K, Buono S, Burgio N, Cotogno G, Gibson N, Maciocco L, Mercurio G, Santagata A, Simonelli F, Tagziria H (2009) Development of an accelerator driven neutron activator for medical radioisotope production. Nucl Instr Meth Phys Res A 601:223-228
3. 2 nanoparticles for radiotracer studies. J Nanopart Res 12:2435-2443
4. Ackland G (2010) Controlling radiation damage. Science 327:1587-1588
5. Aitken RJ, Chaudhry MQ, Boxall ABA, Hull M (2006) Manufacture and use of nanomaterials: current status in the UK and global trends. Occup Med 56:300-306 (Pubitemid 44304820)
6. Arnould H, Bompas CA, Del Moral R, Lacoste V, Vlachoudis V, Aleixandre J, Bueno J, Cerro E, Gonzalez O, Tamarit J, Andriamonje S, Brozzi D, Buono S, Carminati F, Casagrande F, Cennini P, Collar JI, Dumps L, Geles C, Goulas I, Fernandez R, Kadi Y, Klapisch R, Oropesa J, Placci A, Revol J-P, Rubbia C, Rubio JA, Saldana F, Embid M, Galvez J, Lopez C, Perez-Enciso E, Poza M, Sirvent C, Vieira S, Abanades A, Garcia J, Martinez-Val JM, Perlado M, Gonzalez E, Hussonnois M, Le Naour C, Trubert D, Belle E, Giorni A, Heuer D, Loiseaux JM, Meplan O, Nifenecker H, Schussler F, Viano JB, Angelopoulos A, Apostolakis A, Karaiskos P, Sakelliou L, Kokkas P, Pavlopoulos P, Eleftheriadis C, Kitis G, Papadopoulos I, Savvidis E, Tzima A, Zioutas K, Diez S, Perez-Navarro A (1999) Experimental verification of neutron phenomenology in lead and transmutation by adiabatic resonance crossing in accelerator driven systems. Physics Letters B 458:167-180
7. Bagwe RP, Yang C, Hilliard LR, Tan W (2004) Optimization of dye-doped silica nanoparticles prepared using reverse microemulsion method. Langmuir 20:8336-8342
8. Bai X-M, Voter AF, Hoagland RG, Nastasi M, Uberuaga BP (2010) Efficient annealing of radiation damage near grain boundaries via interstitial emission. Science 327:1631-1634
9. Balbus JM, Florini K, Denison RA, Walsh SA (2007) Protectingworkers and the environment: an environmental NGO's perspective on nanotechnology. Journal of Nanoparticles Research 9:11-22 (Pubitemid 46036107)
10. Baldi G, Bonacchi D, Innocenti C, Lorenzi G, Sangregorio C (2007) Cobalt ferrite nanoparticles: the control of the particle size and surface state and their effects on magnetic properties. Journal of Magnetism and Magnetic Materials 311:10-16 (Pubitemid 46420482)
11. Banhart F (1999) Irradiation effects in carbon nanostructures. Rep Progr Phys 62:1181-1221
12. Banhart F (2006) Irradiation of carbon nanotubes with a focused electron beam in the electron microscope. J Mater Sci 41:4505-4511
13. Bodemann R, Lange HJ, Leya I, Michel R, Schiekel T, Rosel R, Herpers U, Hofmann HJ, Dittrich B, Suter M, Wolfli W, Holmqvist B, Conde H, Maimborg P (1993) Production of residual nuclei by proton-induced reaction on C, N, O, Mg, Al and Si. Nucl Inst Meth Phys Res B 82:9-31
14. Brunauer S, Emmet PH, Teller E (1938) Adsorption of gases in multimolecular layers. J Am Chem Soc 60:309
15. Cao J, Wang Y, Yu J, Xia J, Zang C, Yin D, Häfeli UO (2004) Preparation and radiolabeling od surface-modified magnetic nanoparticles with rhenium-188 for magnetic targeted radiotherapy. J Magnetism Magnetic Materials 277:165-174
16. Caps R, Fricke J (2000) Thermal conductivity of opacified powder filler materials for vacuum insulations. Int J Thermophysics 21:445-452
17. De Kok TMCM, Driece HAL, Hogervorst JGF, Briedé JJ (2006) Toxicological assessment of ambient traffic-related particulate matter: a review of recent studies. Mutat Res 613:103-122 (Pubitemid 44750846)
18. DeLouise L, Mortensen L, Elder A (2009) Breeching epithelial barriers-physiochemical factors impacting nanomaterial translocation and toxicity. In: Webster TJ (ed) Safety of nanoparticles, nanostructure science and technology. Springer, Berlin, pp 33-62
19. Fischer FD, Waitz T, Vollath D, Simha NK (2008) On the role of surface energy and surface stress in phase-transforming nanoparticles. Prog Mater Sci 53:481-527
20. Froment P, Tilquin I, Cogneau M, Delbar Th, Vervier J, Ryckewaert G (2002) The production of radioisotopes for medical applications by the adiabatic resonance crossing (ARC) technique. Nucl Instr Meth Phys Res A 493:165-175 (Pubitemid 35282193)
21. Geiser M, Kreyling W (2010) Deposition and kinetics of inhaled nanoparticles. Particle Fibre Toxicol. doi:10.1186/1743-8977-7-2
22. Geiser M, Rothen-Rutishauser B, Kapp N, Schürch S, Kreyling W, Schulz H, Semmler M, Im Hof V, Heyder J, Gehr P (2005) Ultrafine particles cross cellular membranes by non-phagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 113:1555-1560 (Pubitemid 41614911)
23. Gul MO, Jones SA, Dailey LA, Nacer H, Ma Y, Sadouki F, Hider R, Forbes B (2009) A poly(vinyl alcohol) nanoparticle platform for kinetic studies of inhaled particles. Inhalation Toxicology 21:631-640
24. Haddad F, Ferrer L, Guertin A, Carlier T, Michel N, Barbet J, Chatal J-F (2008) ARRONAX, a high-energy and high-intensity cyclotron for nuclear medicine. European Journal of Nuclear Medicine and Molecular Imaging 35:1377-1387
25. Häfeli UO, Roberts WK, Pauer GJ, Kraeft S-K, Macklis RM (2001) Stability of biodegradable rhenium (Re-186 and Re-188) microspheres after neutron activation. Appl Radiat Isot 54:869-879 (Pubitemid 32157526)
26. Hamoudeh M, Fessi H, Mehier H, Al Faraj A, Canet-Soulas E (2008a) Dirhenium decacarbonyl-loaded PLLA nanoparticles: Influence of neutron irradiation and preliminary in vivo administration by the TMT technique. International Journal of Pharmaceutics 348:125-136 (Pubitemid 350278552)
27. Hamoudeh M, Kamleh MA, Diab R, Fessi H (2008b) Radionuclides delivery systems for nuclear imaging and radiotherapy of cancer. Adv Drug Deliv Rev 60:1329-1346
28. Handy RD, Henry TB, Scrown TM, Johnston BD, Tyler CR (2008) Manufactured nanoparticles: their uptake and effects on fish. Ecotoxicology 15:396-409
29. He C, Sasaki T, Usui H, Shimizu Y, Koshizaki N (2007) Fabrication of ZnO nanoparticles by pulsed laser ablation in aqueous media and pH-dependent particle size: an approach to study the mechanism of enhanced green photoluminescence. J Photochem Photobiol A Chemistry 191:66-73
30. Helsper C, Mölter W, Löffler F, Wadenpohl C, Kaufmann S, Wenninger G (1993) Investigations of a new aerosol generator for the production of carbon aggregate particles. Atmos Environ 27A:1271-1275
31. Hemon S, Gourbilleau F, Dufour Ch, Paumier E, Dooryhee E, Rouanet A (1997) TEM study of irradiation effects on tin oxide nanopowder. Nucl Instr Meth Phys Res B 122:526-529 (Pubitemid 127377507)
32. Hinds WC (1982) Aerosol technology: properties, behavior and measurement of airborne particles. Wiley, New York
33. Hirschhorn JS (1969) Introduction to powder metallurgy. American Powder Metallurgy Institute, New York
34. Hoet PHM, Brüske-Hohlfeld I, Salata OV (2004) Nanoparticles - known and unknown health risks. J Nanobiotechnology 2:12. doi:10.1186/1477-3155-2-12
35. Hong H, Zhang Y, Sun J, Cai W (2009) Molecular imaging and therapy of cancer with radiolabeled nanoparticles. Nano Today 4:399-413
36. Hümmer E, Rettelbach Th, Lu X, Fricke J (1993) Opacified silica aerogel powder insulation. Thermochimica Acta 218C:269-276
37. IAEA (2008) Experimental Nuclear Reaction Data (EXFOR). Available under http://www-nds.iaea.org/exfor/exfor.htm (continuously updated)
38. Inagaki M, Kondo N, Nonaka R, Ito E, Toyoda M, Sogabe K, Tsumura T (2009) Structure and photoactivity of titania derived from nanotubes and nanofibres. J Hazardous Materials 161:1514-1521
39. Jain PK, El-Sayed IH, El-Sayed MA (2007) Au nanoparticles target carrier. Nanotoday 2:18-29
40. Jain R, Dandekar P, Patravale V (2009) Diagnostic nanocarriers for sentinel lymph node imaging. Journal of Controlled Release 138:90-102
41. Jia X, Chen X, Lu Y, Han X, Xu Z (2009) Tracing transport of chitosan nanoparticles and molecules in Caco-2 cells by fluorescent labelling. Carbohydr Polym 78:323-329
42. Kanapilly GM, Goh CH (1973) Some factors affecting the in vitro rates of dissolution of respirable particles of relatively low solubility. Health Phys 25:225-237
43. Kapp N, Kreyling W, Schulz H, Im Hof V, Gehr P, Semmler M, Geiser M (2004) Electron energy loss spectroscopy for analysis of inhaled ultrafine particles in rat lungs. Microsc Res Tech 63(5):298-305 (Pubitemid 38702358)
44. Kaur S, Nieuwenhuijsen MJ, Colvile RN (2007) Fine particulate matter and carbon monoxide exposure concentrations in urban street transport microenvironments. Atmos Environ 41:4781-4810 (Pubitemid 46836859)
45. Kilmametov AR, Gunderov DV, Valiev RZ, Balogh AG, Hahn H (2008) Enhanced ion irradiation resistance of bulk nanocrystalline TiNi alloy. Scripta Mater 59:1027-1030
46. Krasheninnikov AV, Banhart F (2007) Engineering of nanostructured carbon materials with electron and ion beams. Nature Materials 6:723-733 (Pubitemid 47515308)
47. Krewski D, Rainham D (2007) Ambient air pollution and population health: overview. J Toxicol Environm Health Part A 70:275-283 (Pubitemid 46294864)
48. Kreyling WG, Godleski JJ, Kariya ST, Rose RM, Brain JD (1990) In vitro dissolution of uniform cobalt oxide particles by human and canine alveolar macrophages. Am J Respir Cell Mol Biol 2:413-422
49. Kreyling WG, Semmler M, Erbe F, Mayer P, Takenaka S, Schulz H, Oberdörster G, Ziesenis A (2002) Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. J Toxicol Environ Health 65:1513-1530 (Pubitemid 35217498)
50. Kreyling WG, Biswas P, Messing ME, Gibson N, Geiser M, Wenk A, Sahu M, Deppert K, Cydzik I, Wigge C, Schmid O, Semmler-Behnke M (2010) Generation and characterization of stable, highly concentrated titanium dioxide nanoparticle aerosols for rodent inhalation studies. J Nanopart Res 13:511-524
51. Laden F, Neas LM, Dockery DW, Schwartz J (2000) Association of fine particulate matter from different sources with daily mortality in six U.S. cities. Environ Health Perspect 108:941-947
52. Laden F, Schwartz J, Speizer FE, Dockery DW (2006) Reduction in fine particulate air pollution and mortality: Extented follow-up of the Harvard Six Cities study. Am J Respir Crit Care Med 173:667-672 (Pubitemid 43363809)
53. Li Q, Sasaki T, Koshizaki N (1999) Pressure dependence of the morphology and size of cobalt(II, III)oxide nanoparticles prepared by pulsed laser ablation. Appl Phys A69:115-118
54. Liang XG, Ge XS, Chang YP, Liu G, Wu DP (1992) The measurement of thermal conductivities of silica and carbon black powders at different pressures by thermal conductivity probe. Journal of Themal Science 1:75-79
55. 188Re for bio-magnetically targeted radiotherapy. J Radioanal Nucl Chem 269:3-7
56. Lieser KH (2001) Nuclear and radiochemistry - fundamentals and applications, 2nd edn. Wiley, New York
57. Lysenko V, Roussel PH, Remaki B, Delhomme G, Dittmar A, Barbier D, Strikha V, Martelet C (2000) Study of nano-porous silicon with low thermal conductivity as thermal insulating material. J Porous Mater 7:177-182 (Pubitemid 30536294)
58. Ma ZY, Dosev D, Kennedy IM (2009) A microemulsion preparation of nanoparticles of europium in silica with luminescence enhancement using silver. Nanotechnology 20. doi:10.1088/0957-4484/20/8/085608
59. Magill J, Pfennig G, Galy J (2006) Karlsruher Nuklidkarte, 7th edn. Haberbeck GmbH, Germany
60. Mailänder V, Landfester K (2009) Interaction of nanoparticles with cells. Biomolecules 10:2379-2400
61. 4 nanoparticles for in vitro uptake studies on Balb/3T3 and Caco-2 cell lines. J Nanopart Res (submitted)
62. Maynard AD, Kuempel ED (2005) Airborn nanostructured particles and occupational health. J Nanoparticle Research 7:587-614 (Pubitemid 41767360)
63. Mughabghab SF (2006) Atlas of neutron resonances-resonance parameters and thermal cross sections Z = 1-100, 5th edn. Elsevier, Amsterdam
64. Nijsen JFW, Zonnenberg BA, Woittiez JRW, Rook DW, Swildens-Van Woudenberg IA, Van Rijk PP, Van het Schip AD (1999) Holmium-166 poly lactic acid microspheres applicable for intraarterial radionuclide therapy of hepatic malignancies: Effects of preparation and neutron activation techniques. Eur J Nucl Med 26:699-704
65. Nita N, Schaeublin R, Victoria M (2004) Impact of irradiation on the microstructure of nanocrystalline materials. J Nucl Mat 329-333:953-957
66. Oberdörster G, Oberdörster E, Oberdörster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823-839
67. OECD (2008) OECD environment, health and safety publications, series on the safety of manufactured nanomaterials no. 6: working party on manufactured nanomaterials: list of manufactured nanomaterials and list of endpoints for phase one of the OECD testing programme ENV/JM/MONO(2008)13/REV. Organisation for Economic Co-Operation and Development, Paris
68. OECD-NEA (2009) Joint evaluated fission and fusion file (JEFF), version JEFF 3.1.1. http://www.nea.fr/dbforms/data/eva/evatapes/jeff-31/
69. Oughton DH, Hertel-Aas T, Pellicer E, Mendoza E, Joner EJ (2008) Neutron activation of engineered nanoparticles as a tool for tracing their environmental fate and uptake in organisms. Environ Toxicol Chem 27:1883-1887
70. Podgoršak EB (2006) Radiation physics for medical physicists. Springer, Berlin
71. Ponti J, Colognato R, Franchini F, Gioria S, Simonelli F, Abbas K, Uboldi C, Kirkpatrick CJ, Holzwarth U, Rossi F (2009) A quantitative in vitro approach to study the intracellular fate of gold nanoparticles: from synthesis to cytotoxicity. Nanotoxicology 3:296-306
72. Pratsinis SE (1998) Flame aerosol synthesis of ceramic powders. Prog Energy Combust Sci 24:197-219
73. Prussin SG (2007) Nuclear physics for applications. Wiley, Berlin
74. Puretzky AA, Geohegan DB, Fan X, Pennycook SJ (2000) Dynamics of single-wall carbon nanotube synthesis by laser vaporization. Appl Phys A70:153-160
75. 64Cu-labeled folate-conjugated shell cross-linked nano-particles for tumor imaging and radiotherapy: synthesis, radio-labeling, and biologic evaluation. J Nucl Med 46:1210-1218
76. Roth C, Ferron GA, Karg E, Lentner B, Schumann G, Takenaka S, Heyder J (2004) Generation of ultrafine particles by spark discharging. Aerosol Sci Technol 38:228-235 (Pubitemid 38174687)
77. Rubbia C (1997) Resonance enhanced neutron captures for element activation and waste transmutation. CERN-LHC/97-0040EET
78. Rubbia C (1998) Patent PTC WO 98/59347
79. Samaras M, Derlet PM, Van Swygenhoven H, Victoria M (2006) Atomic scale modelling of the primary damage state of irradiated fcc and bcc nanocrystalline metals. J Nucl Mat 351:47-55 (Pubitemid 44209063)
80. Schrand AM, Johnson J, Dai L, Hussain SM, Schlager JJ; Zhu L, Hong Y, Osawa E (2009) Cytotoxicity and genotoxicity of carbon nanomaterials. In: Webster TJ (ed) Safety of nanoparticles, nanostructure science and technology. Springer, Berlin, pp 159-187
81. Shultis JK, Faw RE (2002) Fundamentals of nuclear science and engineering. Marcel Dekker, New York
82. Shultz MD, Calvin S, Fatouros PP, Morrison SA, Carpenter EE (2007) Enhanced ferrite nanoparticles as MRI contrast agents. Journal of Magnetism and Magnetic Materials 311:464-468 (Pubitemid 46401047)
83. 2 nanoparticles and their application for in vitro uptake studies. IEEE Trans NanoBiosci (submitted)
84. Sofou S (2008) Radionuclide carriers for targeting cancer. International Journal of Nanomedicine 3:181-199
85. Stoller RE, Kamenski Osetsky, Yu N (2009) Length-scale effects in cascade damage production in iron. Mater Res Soc Symp Proc 1125:109-120
86. Tan W, Wang K, He X, Zhao XJ, Drake T, Wang L, Bagwe RP (2004) Bionanotechnology based on silica nanoparticles. Med Res Rev 24:621-638 (Pubitemid 39038230)
87. 165Ho metallofullerenes. Chem Phys Lett 308:329-336
88. Tilquin I, Froment P, Cogneau M, Delbar Th, Vervier J, Ryckewaert G (2005) Experimental measurements of neutron fluxes produced by proton beams (23-80 MeV) on Be and Pb targets. Nucl Instr Meth Phys Res A 545:339-343 (Pubitemid 40710000)
89. Tovmachenko OG, Graf C, van den Heuvel DJ, van Blaaderen A, Gerritsen HC (2006) Fluorescence enhancement by metal-core/ silica-shell nanoparticles. Adv Mater 18:91-95 (Pubitemid 43076269)
90. Vollath D (1994) A cascaded microwave plasma source for synthesis of ceramic nanocomposite powders. Mater Res Soc Symp Proc 347:629-634
91. Vollath D (2008) Nanomaterials: an introduction to synthesis, properties and application. Wiley, Weinheim; ISBN: 978-3-527-31531-4
92. Vollath D, Sickafus KE (1992) Synthesis of nanosized ceramic oxide powders by microwave plasma reactions. NanoStruct Mater 1:427-438
93. Wooldridge MS (1998) Gas phase combustion synthesis of particles. Prog Energy Combust Sci 24:63-87
94. Xu Y, Li Q (2007) Multiple fluorescent labelling of silica nanoparticles with lanthanide chelates for highly sensitive time-resolved immunofluorometric assays. Clin Chem 53:1505-1510
95. Zawadski M (2008) Preparation and characterization of ceria nanoparticles by microwave-assisted solvothermal process. J Alloys Compounds 454:347-351
96. Zhang C, Cao J, Yin D, Wang Y, Feng Y, Tan J (2004) Preparation and radiolabeling of human serum albumin (HAS)-coated magnetite nanoparticles for magnetically targeted therapy. Appl Radiat Isot 61:1255-1259
97. Zhu XP, Suzuki T, Nakayama T, Suematsu H, Jiang W, Niihara K (2006) Underwater laser ablation approach to fabricating mono-disperse metallic nanoparticles. Chem Phys Lett 427:127-131 (Pubitemid 44118909)
98. Ziegler JF, Biersack JP, Ziegler MD (2008) SRIM - the stopping and range of ions in matter. See http://www.srim.org/