Yeast-incorporated gallium promotes fracture healing by increasing callus bony area and improving trabecular microstructure on ovariectomized osteopenic rats

Biological Trace Element Research

Volumn 141, Issue 1-3, 2011, Pages 207-215

  Pei, Yi ^a   Fu, Qin ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Callus area; Fracture healing; Micro CT; Osteoporosis; Ovariectomized rats; Trabecular structure; Yeast incorporated gallium

Indexed keywords

GALLIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE MINERAL; BONE STRUCTURE; CALLUS; CHEMICAL ANALYSIS; CONTROLLED STUDY; FEMALE; FEMUR; FRACTURE HEALING; HISTOPATHOLOGY; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSTEOPENIA; OVARIECTOMY; PLATE FIXATION; RAT; TRABECULAR BONE; YEAST;

ANIMALS; BONE DENSITY; BONE DISEASES, METABOLIC; BONY CALLUS; DIETARY SUPPLEMENTS; FEMALE; FRACTURES, BONE; GALLIUM; OVARIECTOMY; RATS; RATS, WISTAR; SACCHAROMYCES CEREVISIAE;

ANIMALIA; RATTUS;

EID: 79959616748     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-010-8708-z     Document Type: Article

References (35)

1. Peck WA (1993) Consensus development conference: diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 94(6):646-650
2. Lill CA, Hesseln J, Schlegel U, Eckhardt C, Goldhahn J, Schneider E (2003) Biomechanical evaluation of healing in a non-critical defect in a large animal model of osteoporosis. J Orthop Res 21:836-842 (Pubitemid 37045561)
3. Namkung-Matthai H, Appleyard R, Jansen J, Hao LJ, Maastricht S, Swain M, Mason RS, Murrell GA, Diwan AD, Diamond T (2001) Osteoporosis influences the early period of fracture healing in a rat osteoporotic model. Bone 28:80-86 (Pubitemid 32112065)
4. Walsh WR, Sherman P, Howlett CR, Sonnabend DH, Ehrlich MG (1997) Fracture healing in a rat osteopenia model. Clin Orthop 342:218-227 (Pubitemid 27400821)
5. Waters RV, Gamradt SC, Asnis P, Vickery BH, Avnur Z, Hill E, Bostrom M (2000) Systemic corticosteroids inhibit bone healing in a rabbit ulnar osteotomy model. Acta Orthop Scand 71:316-321 (Pubitemid 30648940)
6. Lill CA, Hesseln J, Schlegel U, Eckhardt C, Goldhahn J, Schneider E (2003) Biomechanical evaluation of healing in a non-critical defect in a large animal model of osteoporosis. J Orthop Res 21:836-842 (Pubitemid 37045561)
7. Cummings SR, Black DM, Rubin SM (1989) Lifetime risks of hip, Colles', or vertebral fracture and coronary heart disease among white postmenopausal women. Arch Intern Med 149:2445-2448 (Pubitemid 19283200)
8. Barrios C, Brostrom LA, Stark A, Walheim G (1993) Healing complications after internal fixation of trochanteric hip fractures: the prognostic value of osteoporosis. J Orthop Trauma 7:438-442
9. Warrell RP Jr (1997) Gallium nitrate for the treatment of bone metastases. Cancer 80:1680-1685
10. Ma Z, Fu Q (2009) Therapeutic effect of organic gallium on ovariectomized osteopenic rats by decreased serum minerals and increased bone mineral content. Biol Trace Elem Res 133(3):342-349
11. Yunxia L (2007) Organic gallium improves tretinoin-induced osteoporosis in rats. J First Milit Med Univ 27:1361-1364 (In Chinese)
12. Han C, Yuan J, Wang Y (2006) Hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium. J Trace Elem Med Biol 20(3):191-196 (Pubitemid 44311020)
13. Han C, Cui B, Wang Y (2008) Vanadium uptake by biomass of Coprinus comatus and their effect on hyperglycemic mice. Biol Trace Elem Res 124:35-39
14. Wang JW, Xu SW, Yang DS, Lv RK (2007) Locally applied simvastatin promotes fracture healing in ovariectomized rat. Osteoporos Int 18:1641-1650 (Pubitemid 47620312)
15. Rundle CH, Wang X, Wergedal JE, Subburaman Mohan K-H, Lau W (2008) Fracture healing in mice deficient in plasminogen activator inhibitor-1. Calcif Tissue Int 83:276-284
16. Bonnarens F, Einhorn TA (1984) Production of a standard closed fracture in laboratory animal bone. J Orthop Res 2:97-101 (Pubitemid 14034681)
17. Holstein JH, Matthys R, Histing T, Becker SC, Fiedler M, Garcia P, Meier C, Pohlemann T, Menger MD (2009) Development of a stable closed femoral fracture model in mice. J Surg Res 153:71-75
18. Rundle CH, Wang X, Wergedal JE, Subburaman Mohan K-H, Lau W (2008) Fracture healing in mice deficient in plasminogen activator inhibitor-1. Calcif Tissue Int 83:276-284
19. Claes L, Schmalenbach J, Herrmann M, lkü IÖ, Garcia P, Histing T, Obeid R, Schorr H, Herrmann W, Pohlemann T, Menger MD, Holstein JH (2009) Hyperhomocysteinemia is associated with impaired fracture healing in mice. Calcif Tissue Int 85:17-21
20. Habermann B, Kafchitsas K, Olender G, Augat P, Kurth A (2010) Strontium ranelate enhances callus strength more than PTH 1-34 in an osteoporotic rat model of fracture healing. Calcif Tissue Int 86:82-89
21. Gerstenfeld LC, Sacks DJ, Pelis M, Mason ZD, Graves DT, Barrero M, Ominsky MS, Kostenuik PJ, Morgan EF, Einhorn TA (2009) Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing. J Bone Miner Res 24:196-208
22. Kakar S, Einhorn TA, Vora S, Miara LJ, Hon G, Wigner NA, Toben D, Jacobsen KA, Al-Sebaei MO, Song M, Trackman PC, Morgan EF, Gerstenfeld LC, Barnes GL (2007) Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures. J Bone Miner Res 22:1903-1912 (Pubitemid 351229307)
23. Bancroft JD (2002) Enzyme histochemistry and its diagnostic applications. In: Bancroft JD, Gamble M (eds) Theory and practice of histological techniques. Harcourt, New York, pp 593-620
24. Habermann B, Kafchitsas K, Olender G, Augat P, Kurth A (2010) Strontium ranelate enhances callus strength more than PTH 1-34 in an osteoporotic rat model of fracture healing. Calcif Tissue Int 86:82-89
25. Ding WJ, Qian QF, Hou XL et al (2000) Determination of chromium combined with DNA, RNA and proteins in chromium-rich brewer's yeast by NAA. J Radioanal Nucl Chem 244:259-262 (Pubitemid 30451389)
26. Ma Z, Qin Fu (2009) Comparison of the therapeutic effects of yeast-incorporated gallium with those of inorganic gallium on ovariectomized osteopenic rats. Biol Trace Elem Res 134(3):280-287
27. Repo MA, Bockman RS, Betts F (1988) Effect of gallium on bone mineral properties. Calcif Tissue Int 43:300-306 (Pubitemid 18267861)
28. Bockman RS, Boskey AL, Blumenthal NC et al (1986) Gallium increases bone calcium and crystallite perfection of hydroxyapatite. Calcif Tissue 39:376-381
29. Bauer JS, Kohlmann S, Eckstein F, Mueller D, Lochmüller E-M, Link TM (2006) Structural analysis of trabecular bone of the proximal femur using multislice computed tomography: a comparison with dual X-ray absorptiometry for predicting biomechanical strength in vitro. Calcif Tissue Int 78:78-89
30. Link TM, Vieth V, Langenberg R, Meier N, Lotter A, Newitt D, Majumdar S (2003) Structure analysis of high resolution magnetic resonance imaging of the proximal femur: in vitro correlation with biomechanical strength and BMD. Calcif Tissue Int 72:156-165 (Pubitemid 36919536)
31. Link TM (2001) Changes in trabecular bone structure assessed by high-resolution MRI in patients after transplantation. Adv Exp Med Biol 496:31-36
32. Link T,Majumdar S, Augat P, Lin J, Newitt D, LuY, Lane N, Genant H (1998) In vivo high resolutionMRI of the calcaneus: differences in trabecular structure in osteoporosis patients. J Bone Miner Res 13:1175-1182
33. Link T, Saborowski S, Kisters K, Kempkes M, Kosch M, Newitt D, Lu Y, Waldt S, Majumdar S (2002) Changes in calcaneal trabecular bone structure assessed with high resolution MRI in patients with kidney transplantation. Osteoporos Int 2002:119-129
34. Srivastava S, Toraldo G, Weitzmann MN, Cenci S, Ross FP, Pacifici R (2001) Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kB ligand (RANKL)-induced JNK activation. J Biol Chem 276:8836-8840
35. Cournot-Witmer G, Bourdeau A, Lieberherr M, Thil CL, Plachot JJ, Enault G, Bourdon R, Balsan S (1987) Bone modeling in gallium nitrate-treated rats. Calcif Tissue Int 40:270-275 (Pubitemid 19014740)