Anti-C1q antibodies are associated with systemic lupus erythematosus disease activity and lupus nephritis in northeast of China

Clinical Rheumatology

Volumn 30, Issue 7, 2011, Pages 967-973

  Zhang, Cai Qin ^a   Ren, Lei ^a   Gao, Fei ^a   Mu, Feng Yun ^a   You, Yan Qiu ^a   Liu, Yan Hong ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Anti C1q antibody; Disease activity; Lupus nephritis; Systemic lupus erythematosus

Indexed keywords

COMPLEMENT COMPONENT C1Q ANTIBODY; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4;

ANTIBODY BLOOD LEVEL; ARTICLE; CHINA; CONTROLLED STUDY; DISEASE ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMATURIA; HUMAN; HYPOCOMPLEMENTEMIA; INCIDENCE; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEINURIA; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; ANTIBODIES, ANTI-IDIOTYPIC; ANTIRHEUMATIC AGENTS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; BIOLOGICAL MARKERS; CHINA; COMPLEMENT C1Q; FEMALE; HEALTH STATUS; HUMANS; LUPUS NEPHRITIS; MALE; SEVERITY OF ILLNESS INDEX;

EID: 79959615393     PISSN: 07703198     EISSN: 14349949     Source Type: Journal    
DOI: 10.1007/s10067-011-1698-1     Document Type: Article

References (26)

1. Bowness P, Davies KA, Norsworthy PJ et al (1994) Hereditary C1q deficiency and systemic lupus erythematosus. Q J Med 87:455-464 (Pubitemid 24243465)
2. Oelzner P, Deliyska B, Funfstuck R et al (2003) Anti-C1q antibodies and antiendothelial cell antibodies in systemic lupus erythematosus relationship with disease activity and renal involvement. Clin Rheumatol 22:271-278 (Pubitemid 37483619)
3. Marten T, Margarita LT, Eliaka P et al (2006) High prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis. Nephrol Dial Transplant 21:3115-3121
4. Fang QY, Yu F, Tan Y et al (2009) Anti-C1q antibodies and IgG subclass distribution in sera from Chinese patients with lupus nephritis. Nephrol Dial Transplant 24:172-178
5. Chen PC, Wang CR, Liu MF et al (2002) Correlation between the renal C1q deposition and serum anti-C1q antibody: a potential role of anti-C1q antibody in lupus nephritis. Asian Pac J Allergy Immunol 20:223-227
6. Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725
7. Li Y (2008) Lupus nephritis. In: Lu ZY, Zhong NS (eds) Internal medicine. People's Medical, Beijing, pp 863-865
8. Bombardier C, Gladman DD, Hocherg M (1989) Validity and reliability of six systems for the clinical assessment of disease activity in systemic lupus erythematosus. Arthritis Rheum 32:1107-1118
9. Bombardier C, Gladman DD, Urowitz MB et al (1992) Derivation of the SLEDAI-A disease activity index for lupus patients. The Committee for Prognosis Studies in SLE. Arthritis Rheum 35:630-640
10. Siegert C, Daha M, Westedt ML et al (1991) IgG autoantibodies against C1q are correlated with nephritis, dermatitis, hypocomplementemia, and dsDNA antibodies in systemic lupus erythematosus. J Rheumatol 18:230-234
11. Fremeaux-Bacchi V, Noel LH, Schifferli JA (2002) No lupus nephritis in the absence of antiC1q autoantibodies? Nephrol Dial Transplant 17:2041-2043
12. Isenberg DA, Ravirajan CT, Rahman A et al (1997) The role of antibodies to DNA in systemic lupus erythematosus - a review and introduction to an international workshop on DNA antibodies held in London May 1996. Lupus 6:290-304
13. Lloyd W, Schur PH (1981) Immune complexes, complement, and anti-DNA in exacerbations of systemic lupus erythematosus. Medicine (Baltimore) 60:208-217 (Pubitemid 11113007)
14. Inanc M, Donohoe S, Ravirajan CT et al (1998) Anti-beta2-glycoprotein I, anti-prothrombin and anticardiolipin antibodies in a longitudinal study of patients with systemic lupus erythematosus and the antiphospholipid syndrome. Br J Rheumatol 37:1089-1094
15. Amoura Z, Piette JC (2003) Role of the nucleosome in the physiopathology of systemic lupus erythematosus. Ann Med Interne (Paris) 154:25-32 (Pubitemid 36427908)
16. Horvath L, Czirjak L, Fekete B et al (2001) High levels of antibodies against Clq are associated with disease activity and nephritis but not with other organ manifestations in SLE patients. Clin Exp Rheumatol 19:667-672 (Pubitemid 34026830)
17. Siegert CE, Daha MR, Tseng CM et al (1993) Predictive value of IgG autoantibodies against C1q for nephritis in systemic lupus erythematosus. Ann Rheum Dis 52:851-856 (Pubitemid 24019139)
18. Coremans IE, Spronk PE, Boots ma H et al (1995) Changes in antibodies to C1q predict renal relapses in systemic lupus erythematosus. Am J Kidney Dis 26:595-601
19. Moroni G, Trendeleburg M, Del PN et al (2001) Anti-C1q antibodies may help in diagnosing a renal flare in lupus nephritis. Am J Kidney Dis 37:490-498 (Pubitemid 32195287)
20. Gunnarsson I, Sundelin B, Heimburger M et al (2002) Repeated renal biopsy in proliferative lupus nephritis-predictive role of serum C1q and albuminuria. J Rheumatol 29:693-699 (Pubitemid 34303862)
21. Horak P, Hermanova Z, Tichy T et al (2006) C1q complement component and antibodies reflect SLE activity and kidney involvement. Clin Rheumatol 25:532-536 (Pubitemid 44143752)
22. Sinico RA, Radice A, Ikehata M et al (2005) Anti-C1q autoantibodies in lupus nephritis: prevalence and clinical significance. Ann NY Acad Sci 1050:193-200 (Pubitemid 41129436)
23. Botto M, Walport MJ (2002) C1q, autoimmunity and apoptosis. Immunobiology 205:395-406 (Pubitemid 35153956)
24. Barilla-LaBarca ML, Atkinson JP (2003) Rheumatic syndromes associated with complement deficiency. Curr Opin Rheumatol 15:55-60
25. Pickering MC, Botto M, Aylor PR et al (2000) Systemic lupus erythematosus, complement deficiency and apoptosis. Adv Immunol 76:227-334
26. Holers VM (2004) Anti-C1q autoantibodies amplify pathogenic complement activation in systemic lupus erythematosus. J Clin Invest 114:616-619