Impact of blood sampling technique on blood quality and animal welfare in haemophilic mice

Laboratory Animals

Volumn 45, Issue 2, 2011, Pages 114-120

  Holmberg, Heidi ^a   Kiersgaard, Maria Kristina ^a   Mikkelsen, Lars Friis ^a   Tranholm, Mikael ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

Blood collection; FVIII knockout; Mice; Retrobulbar venous plexus; Submandibular vein

Indexed keywords

BLOOD CLOTTING FACTOR 8; GLUCOSE; RECOMBINANT BLOOD CLOTTING FACTOR 7A;

ANIMAL EXPERIMENT; ANIMAL WELFARE; ARTICLE; BLEEDING; BLOOD CLOTTING; BLOOD SAMPLING; FEMALE; GLUCOSE BLOOD LEVEL; HEMOPHILIA; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; THROMBOELASTOGRAPHY; VEIN PUNCTURE;

ANIMAL WELFARE; ANIMALS; BLOOD COAGULATION; BLOOD GLUCOSE; BLOOD SPECIMEN COLLECTION; EYE; FACTOR VII; FACTOR VIII; FEMALE; HEMORRHAGE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SUBMANDIBULAR GLAND; VEINS;

ANIMALIA; MUS;

EID: 79959610978     PISSN: 00236772     EISSN: None     Source Type: Journal    
DOI: 10.1258/la.2010.010129     Document Type: Article

References (33)

1. Diehl KH, Hull R, Morton D, et al. European Federation of Pharmaceutical Industries Association and European Centre for the Validation of Alternative Methods. A good practice guide to the administration of substances and removal of blood, including routes and volumes. J Appl Toxicol 2001;21:15-23
2. Christensen SD, Mikkelsen LF, Fels JJ, Bödvarsdottir TB, Hansen AK. Quality of plasma sampled by different methods for multiple blood sampling in mice. Lab Anim 2009;43:65-71
3. Heimann M, Käsermann HP, Pfister R, Roth DR, Bürki K. Blood collection from the sublingual vein in mice and hamsters: a suitable alternative to retrobulbar technique that provides large volumes and minimizes tissue damage. Lab Anim 2009;43:255-60
4. Aasland KE, Skjerve E, Smith AJ. Quality of blood samples from the saphenous vein compared with the tail vein during multiple blood sampling of mice. Lab Anim 2010;44:25-9
5. Golde WT, Gollobin P, Rodriguez LL. A rapid, simple, and humane method for submandibular bleeding of mice using a lancet. Lab Anim (NY) 2005;34:39-43
6. Angelov O, Schroer RA, Heft S, James VC, Noble J. A comparison of two methods of bleeding rats: the venous plexus of the eye versus the vena sublingualis. J Appl Toxicol 1984;4:258-60
7. Schnell MA, Hardy C, Hawley M, Propert KJ, Wilson JM. Effect of blood collection technique in mice on clinical pathology parameters. Hum Gene Ther 2002;13:155-61
8. Fernández I, Peña A, Del TN, Pérez V, Rodríguez-Cuesta J. Clinical biochemistry parameters in C57BL/6J mice after blood collection from the submandibular vein and retroorbital plexus. J Am Assoc Lab Anim Sci 2010;49:202-6
9. Holmberg HL, Lauritzen B, Tranholm M, Ezban M. Faster onset of effect and greater efficacy of NN1731, compared to rFVIIa, aPCC & FVIII in tail-bleeding in haemophilic mice. J Thromb Haemost 2009;7:1517-22
10. Holmberg HL, Elm T, Tranholm M, Ezban M. Prolonged effect of a long acting rFVIIa on bleeding in haemophilic mice compared with rFVIIa. J Thromb Haemost 2009;7(Suppl 2):Abstract OC-WE-056
11. Ovlisen K, Kristensen AT, Valentino LA, Hakobyan N, Ingerslev J, Tranholm M. Hemostatic effect of recombinant factor VIIa, NN1731 and recombinant factor VIII on needle-induced joint bleeding in hemophilia A mice. J Thromb Haemost 2008;6:969-75
12. Møller F, Tranholm M. A ferric chloride induced arterial injury model used as haemostatic effect model. Haemophilia 2009;16:e216-22
13. Pan J, Liu T, Kim JY, et al. Enhanced efficacy of recombinant FVIII in noncovalent complex with PEGylated liposome in hemophilia A mice. Blood 2009;114:2802-11
14. Bi L, Lawler AM, Antonarakis SE, High KA, Gearhart JD, Kazazian HH, Jr. Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A. Nat Genet 1995;10:119-21
15. Peters RT, Low SC, Kamphaus GD, et al. Prolonged activity of factor IX as a monomeric Fc fusion protein. Blood 2010;115:2057-64
16. Salooja N, Perry DJ. Thrombelastography. Blood Coagul Fibrinolysis 2001;12:327-37
17. Sørensen B, Johansen P, Christiansen K, Woelke M, Ingerslev J. Whole blood coagulation thrombelastographic profiles employing minimal tissue factor activation. J Thromb Haemost 2003;1:551-8
18. Landskroner KA, Olson NC, Jesmok GJ. Thromboelastography measurements of whole blood from factor VIII-deficient mice supplemented with rFVIII. Haemophilia 2005;11:346-52
19. Morrissey JH, Macik BG, Neuenschwander PF, Comp PC. Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation. Blood 1993;81:734-44
20. Wildgoose P, Nemerson Y, Hansen LL, Nielsen FE, Glazer S, Hedner U. Measurement of basal levels of factor VIIa in hemophilia A and B patients. Blood 1992;80:25-8
21. Van Herck H, Baumans V, Van der Craats NR, et al. Histological changes in the orbital region of rats after orbital puncture. Lab Anim 1992;26:53-8
22. Van Herck H, Baumans V, Brandt CJ, et al. Orbital sinus blood sampling in rats as performed by different animal technicians: the influence of technique and expertise. Lab Anim 1998;32:377-86
23. Sørensen B, Ingerslev J. Whole blood clot formation phenotypes in hemophilia A and rare coagulation disorders. Patterns of response to recombinant factor VIIa. J Thromb Haemost 2004;2:102-10
24. Nemzek JA, Bolgos GL, Williams BA, Remick DG. Differences in normal values for murine white blood cell counts and other hematological parameters based on sampling site. Inflamm Res 2001;50:523-7
25. Grouzmann E, Cavadas C, Grand D, et al. Blood sampling methodology is crucial for precise measurement of plasma catecholamines concentrations in mice. Pflugers Arch 2003;447:254-8
26. Krohn TC, Hejgaard K, Hansen AK. Methods for general assessment of the welfare of laboratory rats. Acta Agric Scand A 2001;51(Suppl 30): 118-123
27. Cooper HA, Jones CP, Campion E, Roberts HR, Hedner U. Rationale for the use of high dose rFVIIa in a high-titre inhibitor patient with haemophilia B during major orthopaedic procedures. Haemophilia 2001;7:517-22
28. Van Herck H, Baumans V, Brandt CJ, et al. Blood sampling from the retro-orbital plexus, the saphenous vein and the tail vein in rats: comparative effects on selected behavioural and blood variables. Lab Anim 2001;35:131-9
29. Van Herck H, Baumans V, Boere HA, Hesp AP, van Lith HA, Beynen AC. Orbital sinus blood sampling in rats: effects upon selected behavioural variables. Lab Anim 2000;34:10-19
30. Van Herck H, De Boer SF, Hesp AP, van Lith HA, Baumans V, Beynen AC. Orbital bleeding in rats while under diethylether anaesthesia does not influence telemetrically determined heart rate, body temperature, locomotor and eating activity when compared with anaesthesia alone. Lab Anim 1997;31:271-8
31. Van Herck H, Baumans V, De Boer SF, van der GJ, van Woerkom AB, Beynen AC. Endocrine stress response in rats subjected to singular orbital puncture while under diethyl-ether anaesthesia. Lab Anim 1991; 25:325-9
32. Fitzner TM, Petersen MHAU, Dragsted N, Hansen AK. The impact of different blood sampling methods on laboratory rats under different types of anaesthesia. Lab Anim 2006;40:261-74
33. Gärtner K, Büttner D, Döhler K, Friedel R, Lindena J, Trautschold I. Stress response of rats to handling and experimental procedures. Lab Anim 1980;14:267-74