Synthesis of 2-methyl N10-substituted acridones as selective inhibitors of multidrug resistance (MDR) asociated protein in cancer cells

Medicinal Chemistry

Volumn 4, Issue 5, 2008, Pages 457-465

  Mayur, Y C ^a,b   Ahmad, Osman ^b   Prasad, V V S Rajendra ^b   Purohit, M N ^c   Srinivalusu, N ^b   Kumar, S M Shanta ^b  

^a University of Amsterdam   (Netherlands)

^b VL College of Pharmacy   (India)

^c JSS COLLEGE OF PHARMACY   (India)

Author keywords

Acridones; Anti cancer; Multidrug resistance (MDR); P glycoprotein (p gp)

Indexed keywords

10 (3' N MORPHOLINOPROPYL) 2 METHYLACRIDONE; 10 (3' N PIPERIDINOPROPYL) 2 METHYLACRIDONE; 10 (3' N PYRROLIDINOBUTYL) 2 METHYLACRIDONE; 10 (4' N MORPHOLINOBUTYL) 2 METHYLACRIDONE; 10 [3' (N DIETHYLAMINO)BUTYL] 2 METHYLACRIDONE; 10 [3' [N BIS(HYDROXYETHYL)AMINO]BUTYL] 2 METHYLACRIDONE; 10 [3' N [(BETA HYDROXYETHYL)PIPERAZINO]PROPYL] 2 METHYLACRIDONE; ACRIDONE DERIVATIVE; CYTOTOXIC AGENT; DOXORUBICIN; GLYCOPROTEIN P INHIBITOR; UNCLASSIFIED DRUG; VERAPAMIL; VINBLASTINE;

ALKYLATION; ARTICLE; BINDING COMPETITION; CELL STRAIN MCF 7; CHEMICAL REACTION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG RESISTANCE; DRUG RESISTANCE REVERSAL; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIPOPHILICITY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; ULLMANN CONDENSATION REACTION;

ACRIDONES; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; HUMANS; MODELS, CHEMICAL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN;

EID: 57349153493     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340608785700180     Document Type: Article

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