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1
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33748794547
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Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
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Free web link
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T. C. Chou, Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies, Pharmacol. Rev., 2006, 58, 621-681. (Free web link: http://pharmrev.aspetjournals.org/cgi/ reprint/58/3/621).
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(2006)
Pharmacol. Rev.
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Chou, T.C.1
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2
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0017076160
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Derivation and properties of Michaelis-Menten type and Hill type equations for reference ligands
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T. C. Chou, Derivation and properties of Michaelis-Menten type and Hill type equations for reference ligands, J. Theor. Biol., 1976, 59, 253-276.
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(1976)
J. Theor. Biol.
, vol.59
, pp. 253-276
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Chou, T.C.1
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3
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0015345766
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Combinatorial analysis of multiple substrate-multiple product enzyme reactions
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T. C. Chou, Combinatorial analysis of multiple substrate-multiple product enzyme reactions, J. Theor. Biol., 1972, 35, 285-297.
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(1972)
J. Theor. Biol.
, vol.35
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Chou, T.C.1
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4
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0017617685
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On the determination of availability of ligand binding sites in steady-state systems
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T. C. Chou, On the determination of availability of ligand binding sites in steady-state systems, J. Theor. Biol., 1977, 65, 345-356.
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(1977)
J. Theor. Biol.
, vol.65
, pp. 345-356
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Chou, T.C.1
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5
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0016379917
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Relationships between inhibition constants and fractional inhibition in enzyme-catalyzed reactions with different numbers of reactants, different reaction mechanisms, and different types and mechanisms of inhibition
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T. C. Chou, Relationships between inhibition constants and fractional inhibition in enzyme-catalyzed reactions with different numbers of reactants, different reaction mechanisms, and different types and mechanisms of inhibition, Mol. Pharmacol., 1974, 10, 235-247.
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(1974)
Mol. Pharmacol.
, vol.10
, pp. 235-247
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Chou, T.C.1
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6
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0025024779
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Determination of availability of ligand binding site at steady state for topological assessment of receptors with the aid of microcomputers
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T. C. Chou and J. H. Chou, Determination of availability of ligand binding site at steady state for topological assessment of receptors with the aid of microcomputers, Eur. J. Pharmacol., 1990, 183, 921.
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(1990)
Eur. J. Pharmacol.
, vol.183
, pp. 921
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Chou, T.C.1
Chou, J.H.2
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7
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0002658306
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In the median-effect principle and the combination index for quantitation of synergism and antagonism
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ed. T. C. Chou and D. C. Rideout, Academic Press, San Diego
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T. C. Chou, in The median-effect principle and the combination index for quantitation of synergism and antagonism, ed. T. C. Chou and D. C. Rideout, Synergism and Antagonism in Chemotherapy, Academic Press, San Diego, 1991, pp. 61-102.
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(1991)
Synergism and Antagonism in Chemotherapy
, pp. 61-102
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Chou, T.C.1
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8
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0003758883
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Elsevier-Biosoft, Cambridge (UK)
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50, Synergism, Antagonism, Low-Dose Risk, Receptor Ligand Binding and Enzyme Kinetics: Computer Software for the IBM PC Series, Elsevier-Biosoft, Cambridge (UK), 1989.
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(1989)
50, Synergism, Antagonism, Low-Dose Risk, Receptor Ligand Binding and Enzyme Kinetics: Computer Software for the IBM PC Series
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Chou, J.H.1
Chou, T.C.2
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11
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79953313146
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The mass-action law based GPS concept for bioinformatics
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(npre.2008.2064-2); July 22, Available free at
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T. C. Chou, The mass-action law based GPS concept for bioinformatics, Nature Precedings (npre.2008.2064-2); July 22, 2008. Available free at http://precedings.nature.com/documents/2064/version/2.
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(2008)
Nature Precedings
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Chou, T.C.1
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12
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57049155922
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Preclinical versus clinical drug combination studies
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T. C. Chou, Preclinical versus clinical drug combination studies, Leuk. Lymphoma, 2008, 49, 2059-2080.
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(2008)
Leuk. Lymphoma
, vol.49
, pp. 2059-2080
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Chou, T.C.1
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13
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76549129820
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Drug combination studies and their synergy quantification using the Chou-Talalay method
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T. C. Chou, Drug combination studies and their synergy quantification using the Chou-Talalay method, Cancer Res., 2010, 70, 440-446.
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(2010)
Cancer Res.
, vol.70
, pp. 440-446
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Chou, T.C.1
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14
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79959573356
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On the complement between ancient Chinese philosophy and modern science algorithms
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made available by the Conference Organizer in electronic CD, No. D-16
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T. C. Chou, On the complement between ancient Chinese philosophy and modern science algorithms, 16th International Conference of Chinese Philosophy, Taipei, July 8-11, 2009 (made available by the Conference Organizer in electronic CD, No. D-16).
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16th International Conference of Chinese Philosophy, Taipei, July 8-11, 2009
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Chou, T.C.1
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15
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79959548584
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Yijing concept in contemporary mathematics, topology, and sciences
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T. C. Chou, Yijing concept in contemporary mathematics, topology, and sciences, The 13th I-Ching World Conference, Wuxi, China. June 14-17, 2010; p. 642-653.
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The 13th I-Ching World Conference, Wuxi, China. June 14-17, 2010
, pp. 642-653
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Chou, T.C.1
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16
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0019124506
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Comparison of dose-effect relationships of carcinogens following lose-dose chronic exposure and high-dose single injection: An analysis by the median-effect principle
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T. C. Chou, Comparison of dose-effect relationships of carcinogens following lose-dose chronic exposure and high-dose single injection: an analysis by the median-effect principle, Carcinogenesis, 1980, 1, 203-213.
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(1980)
Carcinogenesis
, vol.1
, pp. 203-213
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Chou, T.C.1
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17
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0003030325
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Applications of the median-effect principle for the assessment of low-dose risk of carcinogens and for the quantitation of synergism and antagonism of chemotherapeutic agents
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ed. K. R. Harrap and T. A. Connors, Academic Press, New York
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T. C. Chou and P. Talalay, in Applications of the median-effect principle for the assessment of low-dose risk of carcinogens and for the quantitation of synergism and antagonism of chemotherapeutic agents, in New Avenues in Developmental Cancer Chemotherapy, ed. K. R. Harrap and T. A. Connors, Academic Press, New York, 1987, pp. 37-64.
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(1987)
New Avenues in Developmental Cancer Chemotherapy
, pp. 37-64
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Chou, T.C.1
Talalay, P.2
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18
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57049188721
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Drug combination against xenograft tumors in nude mice: Experimental design, execution, and computerized simulation of synergism and antagonism (An abstract for the mini-symposium)
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T. C. Chou, Drug combination against xenograft tumors in nude mice: Experimental design, execution, and computerized simulation of synergism and antagonism (An abstract for the mini-symposium), Proc. Am. Assoc. Cancer Res., 2008, 49, 997.
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(2008)
Proc. Am. Assoc. Cancer Res.
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, pp. 997
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Chou, T.C.1
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19
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17144467145
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Synergy, activity and tolerability of zidovudine and interferon-alpha in patients with symptomatic HIV-1 infection: ACTG 068
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D. Mildvan, et al. Synergy, activity and tolerability of zidovudine and interferon-alpha in patients with symptomatic HIV-1 infection: AIDS Clinical Trial Group 068, Antivir. Ther., 1996, 1, 77-88. (Pubitemid 126690051)
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Berge, P.19
Marshak, A.20
Pettinelli, C.21
more..
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0000994406
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Analysis of combined drug effects: A new look at a very old problem
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T. C. Chou and P. Talalay, Analysis of combined drug effects: a new look at a very old problem, Trends Pharmacol. Sci., 1983, 4, 450-454.
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Chou, T.C.1
Talalay, P.2
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21
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0021118703
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Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
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T. C. Chou and P. Talalay, Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors, Adv. Enzyme Regul., 1984, 22, 27-55.
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(1984)
Adv. Enzyme Regul.
, vol.22
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Chou, T.C.1
Talalay, P.2
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22
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34547879278
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What is synergy?
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T. C. Chou, What is synergy? Scientist, 2007, 21, 15.
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Scientist
, vol.21
, pp. 15
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Chou, T.C.1
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23
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0028153260
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Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: A rational approach to clinical protocol design
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T. C. Chou, R. J. Motzer, Y. Tong and G. J. Bosl, Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: a rational approach to clinical protocol design, J. Natl. Cancer Inst., 1994, 86, 1517-1524. (Pubitemid 24330215)
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(1994)
Journal of the National Cancer Institute
, vol.86
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Chou, T.-C.1
Motzer, R.J.2
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Bosl, G.J.4
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24
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0000509587
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The employment of combinations of drugs in the chemotherapy of neoplasia: A review
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Goldin, A.1
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The search for synergy: A critical review from a response surface perspective
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Greco, W.R.1
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Parsons, J.C.3
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26
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0017706693
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A simple generalized equation for the analysis of multiple inhibitions of Michaelis-Menten kinetic systems
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T. C. Chou and P. Talalay, A simple generalized equation for the analysis of multiple inhibitions of Michaelis-Menten kinetic systems, J. Biol. Chem., 1977, 252, 6438-6442. (Pubitemid 8193791)
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Journal of Biological Chemistry
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Chou, T.C.1
Talalay, P.2
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27
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0019882480
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Generalized equations for the analysis of inhibitions of Michaelis-Menten and higher-order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors
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T. C. Chou and P. Talalay, Generalized equations for the analysis of inhibitions of Michaelis-Menten and higher-order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors, Eur. J. Biochem., 1981, 115, 207-216.
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Chou, T.C.1
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0001935126
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Die quantitation probleme der pharmacologie
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S. Loewe, Die quantitation probleme der pharmacologie, Ergeb. Physiol., 1928, 27, 47-187.
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Loewe, S.1
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What is synergy?
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Berenbaum, M.C.1
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30
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4243335032
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Computerized simulation of dose-reduction index (DRI) in synergistic drug combinations
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J. H. Chou and T. C. Chou, Computerized simulation of dose-reduction index (DRI) in synergistic drug combinations, Pharmacologist, 1988, 30, A231.
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(1988)
Pharmacologist
, vol.30
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Chou, J.H.1
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31
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57049099631
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Computerized indexing of drug combinations: Prediction of synergism and antagonism of more than two drugs by polygonogram
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abstract
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T. C. Chou and J. Chou, Computerized indexing of drug combinations: prediction of synergism and antagonism of more than two drugs by polygonogram (abstract), FASEB J., 1998, 12, A832.
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FASEB J.
, vol.12
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Chou, J.2
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0032483019
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Desoxyepothilone B: An efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B
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T. C. Chou, et al., Desoxyepothilone B: An efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B, Proc. Natl. Acad. Sci. U. S. A., 1998, 95, 9642-9647.
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Chou, T.C.1
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0032416734
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Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel
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T. C. Chou, et al., Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel, Proc. Natl. Acad. Sci. U. S. A., 1998, 95, 15798-15802.
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(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 15798-15802
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Chou, T.C.1
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0034939512
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The synthesis, discovery and development of a highly promising class of microtubule stabilzation agents: Curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice
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T. C. Chou, et al., The synthesis, discovery and development of a highly promising class of microtubule stabilzation agents: Curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice, Proc. Natl. Acad. Sci. U. S. A., 2001, 98, 8113-8118.
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(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
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Chou, T.C.1
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35
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27144456478
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Therapeutic cure against human tumor xenografts in nude mice by a microtubule stabilization agent, Fludelone, via parenteral or oral route
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T. C. Chou, et al., Therapeutic cure against human tumor xenografts in nude mice by a microtubule stabilization agent, Fludelone, via parenteral or oral route, Cancer Res., 2005, 65, 9445-9454.
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Cancer Res.
, vol.65
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Chou, T.C.1
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51349140042
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Therapeutic cure against human xenograft tumors in nude mice by the third generation microtubule stabilization epothilones
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T. C. Chou, et al., Therapeutic cure against human xenograft tumors in nude mice by the third generation microtubule stabilization epothilones, Proc. Natl. Acad. Sci. U. S. A., 2008, 105, 13157-13162.
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(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 13157-13162
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0029563673
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+ cells per cubic millimeter
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Constructing and exploiting the fluorescent protein paintbox (Nobel lecture)
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R. Y. Tsien, Constructing and exploiting the fluorescent protein paintbox (Nobel lecture), Angew. Chem., Int. Ed., 2009, 48, 5612-5626.
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