Erectile dysfunction, physical activity and metabolic syndrome: Differences in markers of atherosclerosis

BMC Cardiovascular Disorders

Volumn 11, Issue , 2011, Pages

  Pohjantähti Maaroos, Hanna ^a,b,c   Palomäki, Ari ^a,b   Hartikainen, Juha ^c  

^a KANTA HÄME CENTRAL HOSPITAL   (Finland)

^b Linnan Klinikka ^*  (Finland)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOGEN; LIPID; LOW DENSITY LIPOPROTEIN;

ADULT; ARTERY; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; ELASTICITY; ENERGY EXPENDITURE; ENZYME LINKED IMMUNOSORBENT ASSAY; ERECTILE DYSFUNCTION; EXERCISE; HEART RATE; HUMAN; INTERNATIONAL INDEX OF ERECTILE FUNCTION; LIPID OXIDATION; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PHYSICAL ACTIVITY; PRIORITY JOURNAL; STRUCTURED QUESTIONNAIRE;

EID: 79959562577     PISSN: None     EISSN: 14712261     Source Type: Journal    
DOI: 10.1186/1471-2261-11-36     Document Type: Article

References (57)

1. Stocker R, Keaney JF. Role of oxidative modifications in atherosclerosis. Physiol Rev 2004, 84:1381-1478. 10.1152/physrev.00047.2003, 15383655.
2. Kirby M, Jackson G, Simonsen U. Endothelial dysfunction links erectile dysfunction to heart Disease. Int J Clin Pract 2005, 59:225-229. 10.1111/j.1742-1241.2005.00453.x, 15854201.
3. Cohn J, Finkelstein S, McVeigh G, Morgan D, LeMay L, Robinson J, Mock J. Non-invasive Pulse Wave Analysis for the Early Detection of Vascular Disease. Hypertension 1995, 26:503-508.
4. Boutouyrie P, Tropeano I, Asmar R, Gautier I, Benetos A, Lacolley P, Laurent S. Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients. A longitudinal study. Hypertension 2002, 39:10-15. 10.1161/hy0102.099031, 11799071.
5. Van Popele N, Grobbee D, Bots M, Asmar R, Topouchian J, Reneman R, Hoeks A, Van der Kuip D, Hofman A, Witteman J. Association between arterial stiffness and atherosclerosis. The Rotterdam study. Stroke 2001, 32:454-460. 10.1161/01.STR.32.2.454, 11157182.
6. Holvoet P, Mertens A, Verhamme P, Bogaerts K, Beyens G, Verhaeghe R, Collen D, Muls E, Van de Werf F. Circulating oxidized LDL is a useful marker for identifying patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2001, 21:844-848. 10.1161/01.ATV.21.5.844, 11348884.
7. Fibrinogen Studies Collaboration Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA 2005, 294:1799-1809. Fibrinogen Studies Collaboration.
8. Cooney M, Vartiainen E, Laatikainen T, Juolevi A, Dudina A, Graham I. Elevated resting heart rate is an independent risk factor for cardiovascular disease in healthy men and women. Am Heart J 2010, 159:612-619. 10.1016/j.ahj.2009.12.029, 20362720.
9. Jackson G, Boon N, Eardley I, Kirby M, Dean J, Hackett G, Montorsi P, Montorsi F, Vlachopoulos C, Kloner R, Sharlip I, Miner M. Erectile dysfunction and coronary artery disease prediction: evidence-based guidance and consensus. Int J Clin Pract 2010, 64:848-857. 10.1111/j.1742-1241.2010.02410.x, 20584218.
10. Thompson I, Tangen C, Goodman P, Probstfield J, Moinpour C, Coltman C. Erectile dysfunction and subsequent cardiovascular disease. JAMA 2005, 294:2996-3002. 10.1001/jama.294.23.2996, 16414947.
11. Inman B, Sauver J, Jacobson D, McGree M, Nehra A, Lieber M, Roger V, Jacobsen S. A population-based, longitudinal study of erectile dysfunction and future coronary artery disease. Mayo Clin Proc 2009, 84:108-113. 10.4065/84.2.108, 2664580,2664580, 19181643.
12. Araujo A, Hall S, Ganz P, Chiu G, Rosen R, Kupelian V, Travison T, McKinlay J. Does erectile dysfunction contribute to cardiovascular disease risk prediction beyond the Framingham risk score. J Am Coll Cardiol 2010, 55:350-356. 10.1016/j.jacc.2009.08.058, 2845313, 20117441.
13. Montorsi P, Ravagnani PM, Galli S, Rotatori F, Briganti A, Salonia A, Rigatti P, Montorsi F. The artery size hypothesis: a macrovascular link between erectile dysfunction and coronary artery disease. Am J Cardiol 2005, 96(Suppl):19M-23M.
14. Sisson SB, Camhi SM, Church TS, Martin CK, Tudor-Locke C, Bouchard C, Earnest CP, Smith SR, Newton RL, Rankinen T, Katzmarzyk PT. Leisure time sedentary behaviour, occupational/domestic physical activity and metabolic syndrome in U.S. men and women. Metab Syndr Relat Disord 2009, 7:529-536. 10.1089/met.2009.0023, 2796695, 19900152.
15. Hu G, Qiao Q, Tuomilehto J, Balkau B, Borch-Johnsen K, Pyorala K, . for the DECODE study group Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women. Arch Intern Med 2004, 164:1066-1067. 10.1001/archinte.164.10.1066, 15159263, for the DECODE study group.
16. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III) Final report. Circulation 2002, 106:3143-3421. Third report of the National Cholesterol Education Program (NCEP) expert panel on.
17. Ainsworth B, Haskell W, Whitt M, Irwin M, Swartz A, Strath S, O'Brien W, Basset D, Schmitz K, Emplaincourt P, Jacobs D, Leon A. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 2000, 32:498-516.
18. Rosen R, Riley A, Wagner G, Osterloh I, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997, 6:822-830.
19. Prisant LM, Pasi M, Jupin D, Prisant ME. Assessment of repeatability and correlates of arterial compliance. Blood Press Monit 2000, 7:231-235.
20. Resnick LM, Militianu D, Cunnings AJ, Pipe JG, Evelhoch JL, Soulen RL, Lester MA. Pulse waveform analysis of arterial compliance: relation to other techniques, age, and metabolic variables. Am J Hypertens 2000, 13:1243-1249. 10.1016/S0895-7061(00)01219-X, 11130766.
21. Wilson AM, O'Neal D, Nelson CL, Prior DL, Best JD, Jenkins AJ. Comparison of arterial assessments in low and high vascular disease groups. Am J Hypertens 2004, 17:285-291. 10.1016/j.amjhyper.2003.10.009, 15062880.
22. Zimlichman R, Shargorodsky M, Boaz M, Duprez D, Rahn KH, Rizzoni D, Payeras AC, Hamm C, McVeigh G. Determination of arterial compliance using blood pressure waveform analysis with the CR-2000 system: reliability, repeatability, and establishment of normal values for healthy European population - the seven European sites study (SESS). Am J Hypertens 2005, 18:65-71.
23. Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB. A prospective study of risk factors for erectile dysfunction. J Urol 2006, 176:217-221. 10.1016/S0022-5347(06)00589-1, 16753404.
24. Kratzik CW, Lackner JE, Märk I, Rücklinger E, Schmidbauer J, Lunglmayr G, Schatzl G. How much physical activity is needed to maintain erectile function? Results of The Androx Vienna Municipality study. Eur Urol 2009, 55:509-517. 10.1016/j.eururo.2008.02.020, 18359146.
25. Esposito K, Giugliano F, Di Palo C, Giugliano G, Marfella R, D'Andrea F, D'Armiento M, Giugliano D. Effect of lifestyle changes on erectile dysfunction in obese men. A randomized controlled trial. JAMA 2004, 291:2978-2984. 10.1001/jama.291.24.2978, 15213209.
26. Teles AG, Carreira M, Alarcão V, Sociol D, Aragüés JM, Lopes L, Mascarenhas M, Costa JG. Prevalence, severity, and risk factors for erectile dysfunction in a representative sample of 3,548 Portuguese men aged 40 to 69 years attending primary healthcare centers: results of the Portuguese erectile dysfunction study. J Sex Med 2008, 5:1317-1324. 10.1111/j.1743-6109.2007.00745.x, 18194181.
27. Christensen BS, Grønbaek M, Pedersen BV, Graugaard C, Frisch M, Horansanli K, Boylu U, Kendirci M, Miroglu C. Associations of unhealthy lifestyle factors with sexual inactivity and sexual dysfunctions in Denmark. J Sex Med 2011,
28. Hadaegh F, Zabetian A, Khalili D, Safarkhani M, James WP, Azizi F. A new approach to compare the predictive power of metabolic syndrome defined by a joint interim statement versus its components for incident cardiovascular disease in Middle East Caucasian residents in Tehran. J Epidemiol Community Health 2010,
29. Bal K, Öder M, Şahin A, Karataş C, Demir T, Can E, Gümüş B, Özer K, Şahin O, Esen A. Prevalence of metabolic syndrome and its association with erectile dysfunction among urologic patients: metabolic backgrounds of erectile dysfunction. Urology 2007, 69:356-360. 10.1016/j.urology.2006.09.057, 17275074.
30. Selvin E, Burnett AL, Platz EA. Prevalence and risk factors for erectile dysfunction in the US. Am J Med 2007, 120:151-157. 10.1016/j.amjmed.2006.06.010, 17275456.
31. Ko DT, Hebert PR, Coffey CS, Sedrakyan A, Curtis JP, Krumholz HM. Beta-blocker therapy and symptoms of depression, fatigue, and sexual dysfunction. JAMA 2002, 288:351-357. 10.1001/jama.288.3.351, 12117400.
32. Düsing R. Effect of the angiotensin II antagonist valsartan on sexual function in hypertensive men. Blood Press Suppl 2003, 2:29-34.
33. Doǧru MT, Başar MM, Simşek A, Yuvanç E, Güneri M, Ebinç H, Batislam E. Effects of statin treatment on serum sex steroids levels and autonomic and erectile function. Urology 2008, 71:703-707. 10.1016/j.urology.2007.11.059, 18387399.
34. Ford ES. The metabolic syndrome and C-reactive protein, fibrinogen, and leukocyte count: findings from the Third National Health and Nutrition Examination Survey. Atherosclerosis 2003, 168:351-358. 10.1016/S0021-9150(03)00134-5, 12801619.
35. Church TS, Finley CE, Earnest CP, Kampert JB, Gibbons LW, Blair SN. Relative associations of fitness and fatness to fibrinogen, white blood cell count, uric acid and metabolic syndrome. Int J Obes 2002, 26:805-813.
36. Myint PK, Luben RN, Wareham NJ, Welch AA, Bingham SA, Khaw KT. Physical activity and fibrinogen concentrations in 23,201 men and women in the EPIC-Norfolk population-based study. Atherosclerosis 2008, 198:419-425. 10.1016/j.atherosclerosis.2007.09.021, 17977548.
37. Sinha S, Luben RN, Welch A, Bingham S, Wareham NJ, Day NE, Khaw KT. Fibrinogen and cigarette smoking in men and women in the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population. Eur J Cardiovasc Prev Rehabil 2005, 12:144-150.
38. Vlachopoulos C, Aznaouridis K, Ioakeimidis N, Rokkas K, Vasiliadou C, Alexopoulos N, Stefanadi E, Askitis A, Stefanadis C. Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease. Eur Heart J 2006, 27:2640-2648. 10.1093/eurheartj/ehl341, 17056702.
39. Pohjantähti-Maaroos H, Palomäki A, Kankkunen P, Laitinen R, Husgafvel S, Oksanen K. Circulating oxidized low-density lipoproteins and arterial elasticity: comparison between men with metabolic syndrome and physically active counterparts. Cardiovasc Diabetol 2010, 9:41. 10.1186/1475-2840-9-41, 2931500, 20727144.
40. Ge JY, Li XL, Zhang HF, Xu Q, Tong M, Wang JG. Elasticity indices of large and small arteries in relation to the metabolic syndrome in Chinese. Am J Hypertens 2008, 21:143-147. 10.1038/ajh.2007.26, 18188165.
41. Kaya C, Ergelen M, Ilktac A, Karaman I. Impaired elasticity of aorta in patients with erectile dysfunction. Urology 2007, 70:558-562. 10.1016/j.urology.2007.04.018, 17688916.
42. Vlachopoulos C, Aznaouridis K, Ioakeimidis N, Rokkas K, Tsekoura D, Vasiliadou C, Stefanadi E, Askitis A, Stefanadis C. Arterial function and intima-media thickness in hypertensive patients with erectile dysfunction. J Hypertens 2008, 26:1829-1836. 10.1097/HJH.0b013e3283050886, 18698219.
43. Pohjantähti-Maaroos H, Palomäki A. Comparison of metabolic syndrome subjects with and without erectile dysfunction - levels of circulating oxidised LDL and arterial elasticity. Int J Clin Pract 2011, 65:274-280. 10.1111/j.1742-1241.2010.02595.x, 21314864.
44. Kaiser D, Billups K, Mason C, Wetterling R, Lundberg J, Bank A. Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease. J Am Coll Cardiol 2004, 43:179-184. 10.1016/j.jacc.2003.07.042, 14736434.
45. Yavuzgil O, Altay B, Zoghi M, Gürgün C, Kayi{dotless}kçi{dotless}ǧlu M, Kültürsay H. Endothelial function in patients with vasculogenic erectile dysfunction. Int J Cardiol 2005, 103:19-26. 10.1016/j.ijcard.2004.07.004, 16061118.
46. Sugawara J, Inoue H, Haysashi K, Yokoi T, Kono I. Effect of low-intensity aerobic exercise training on arterial compliance in postmenopausal women. Hypertens Res 2004, 27:897-901. 10.1291/hypres.27.897, 15894828.
47. Elosua R, Molina L, Fito M, Arquer A, Sanchez-Quesada JL, Covas MI, Ordonez-Llanos J, Marrugat J. Response of oxidative stress biomarkers to a 16-week aerobic physical activity program, and to acute physical activity, in healthy young men and women. Atherosclerosis 2003, 167:327-334. 10.1016/S0021-9150(03)00018-2, 12818416.
48. Miyachi M, Kawano H, Sugawara J, Takahashi K, Hayashi K, Yamazaki K, Tabata I, Tanaka H. Unfavorable effects of resistance training on central arterial compliance. A randomized intervention study. Circulation 2004, 110:2858-2863. 10.1161/01.CIR.0000146380.08401.99, 15492301.
49. Muñoz MD, Olcina G, Timón R, Robles MC, Caballero MJ, Maynar M. Effect of different exercise intensities on oxidative stress markers and antioxidant response in trained cyclists. J Sports Med Phys Fitness 2010, 50:93-98.
50. Mancia G, Bousquet P, Elghozi JL, Esler M, Grassi G, Julius S, Reid J, Van Zwieten PA. The sympathetic nervous system and the metabolic syndrome. J Hypertens 2007, 25:909-920. 10.1097/HJH.0b013e328048d004, 17414649.
51. Arnold JM, Fitchett DH, Howlett JG, Lonn EM, Tardif JC. Resting heart rate: a modifiable prognostic indicator of cardiovascular risk and outcomes?. Can J Cardiol 2008, 24(SupplA):3A-8A. 2787005, 18437251.
52. Tomiyama H, Hashimoto H, Tanaka H, Matsumoto C, Odaira M, Yamada J, Yoshida M, Shiina K, Nagata M, Yamashina A, . baPWV/cfPWV Collaboration Group Synergistic relationship between changes in the pulse wave velocity and changes in the heart rate in middle-aged Japanese adults: a prospective study. J Hypertens 2010, 28:687-694. 10.1097/HJH.0b013e3283369fe8, 20051904, baPWV/cfPWV Collaboration Group.
53. Corona G, Mannucci E, Forti G, Maggi M. Hypogonadism, ED, metabolic syndrome and obesity: a pathological link supporting cardiovascular diseases. Int J Androl 2009, 32:587-598. 10.1111/j.1365-2605.2008.00951.x, 19226407.
54. Revnic CR, Nica AS, Revnic F. The impact of physical training on endocrine modulation, muscle physiology and sexual functions in elderly men. Arch Gerontol Geriatr 2007, 44(Suppl 1):339-342.
55. Vlachopoulos C, Rokkas K, Ioakeimidis N, Stefanadis C. Inflammation, metabolic syndrome, erectile dysfunction and coronary artery disease: common links. Eur Urol 2007, 52:1590-1600. 10.1016/j.eururo.2007.08.004, 17707576.
56. Cappelleri J, Rosen R, Smith M, Mishra A, Osterloh I. Diagnostic evaluation of the erectile function domain of the international index of erectile function. Urology 1999, 54:346-351. 10.1016/S0090-4295(99)00099-0, 10443736.
57. O'Donnell AB, Araujo AB, Goldstein I, McKinlay JB. The validity of a single-question self-report of erectile dysfunction. Results from the Massachusetts Male Aging Study. J Gen Intern Med 2005, 20:515-519. 10.1111/j.1525-1497.2005.0076.x, 1490137, 15987326.