Urinary 8-hydroxydeoxyguanosine as a biomarker of oxidative DNA damage in workers exposed to ethylbenzene

Annals of Occupational Hygiene

Volumn 55, Issue 5, 2011, Pages 519-525

  Chang, Fu Kuei ^a   Mao, I Fang ^b   Chen, Mei Lien ^c   Cheng, Shu Fang ^d  

^a I SHOU UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d INSTITUTE OF OCCUPATIONAL SAFETY AND HEALTH   (Taiwan)

Author keywords

8 hydroxydeoxyguanosine; DNA oxidative damage; ethylbezene; mandelic acid

Indexed keywords

8-HYDROXYDEOXYGUANOSINE; BIOLOGICAL INDICES; CONFIDENCE INTERVAL; DIFFUSIVE SAMPLERS; DNA DAMAGES; ETHYLBEZENE; HIPPURIC ACID; MANDELIC ACID; OCCUPATIONAL EXPOSURE; OXIDATIVE DNA DAMAGE; PERSONAL EXPOSURES; PILOT STUDIES; SPRAY PAINTERS; STEPWISE REGRESSION; URINE SAMPLE;

BODY FLUIDS; DAMAGE DETECTION; DNA; OCCUPATIONAL RISKS; PAINT; REGRESSION ANALYSIS; SHIPS; XYLENE;

ETHYLBENZENE;

8 HYDROXYDEOXYGUANOSINE; 8-HYDROXY-2'-DEOXYGUANOSINE; BENZENE DERIVATIVE; BIOLOGICAL MARKER; CREATININE; DEOXYGUANOSINE; DRUG DERIVATIVE; ETHYLBENZENE; HIPPURIC ACID; HIPPURIC ACID DERIVATIVE; MANDELIC ACID; MANDELIC ACID DERIVATIVE; XYLENE;

ADULT; AIR POLLUTANT; ARTICLE; DNA DAMAGE; HUMAN; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; OXIDATIVE STRESS; PILOT STUDY; REGRESSION ANALYSIS; URINE;

ADULT; AIR POLLUTANTS, OCCUPATIONAL; BENZENE DERIVATIVES; BIOLOGICAL MARKERS; CREATININE; DEOXYGUANOSINE; DNA DAMAGE; HIPPURATES; HUMANS; MALE; MANDELIC ACIDS; MIDDLE AGED; OCCUPATIONAL EXPOSURE; OXIDATIVE STRESS; PILOT PROJECTS; REGRESSION ANALYSIS; XYLENES;

EID: 79959522415     PISSN: 00034878     EISSN: 14753162     Source Type: Journal    
DOI: 10.1093/annhyg/mer010     Document Type: Article

References (18)

1. ACGIH. (1996) Threshold limit values for chemical substances and physical agents and biological exposure indices. Cincinnati, OH: American Conference of Governmental Industrial Hygienists.
2. Baker EL, Smith TJ, Landrigan PJ. (1985) The neurotoxicity of industrial solvents: a review of the literature. Am J Ind Med; 8: 207-17. (Pubitemid 15234688)
3. Chan PC, Hasemani JK, Mahleri J et al. (1998) Tumor induction in F344/N rats and B6C3F1 mice following inhalation exposure to ethylbenzene. Toxicol Lett; 99: 23-32. (Pubitemid 29027835)
4. Chang FK, Chen ML, Cheng SF et al. (2007a) Dermal absorption of solvents as a major exposure source among shipyard spray painters. J Occup Environ Med; 49: 430-6.
5. Chang FK, Chen ML, Cheng SF et al. (2007b) Evaluation of dermal absorption and protective effectiveness of respirators for xylene in spray painters. Int Arch Occup Environ Health; 81: 145-50.
6. Engstrom K, Riihimaki V, Laine A. (1984) Urinary disposition of ethylbenzene and m-xylene in man following separate and combined exposure. Int Arch Occup Environ Health; 54: 355-63. (Pubitemid 15215676)
7. Kaneko T, Tahara S, Matsuo M. (1996) Non-linear accumulation of 8-hydroxy-2-deoxyguanosine, a marker of oxidized DNA damage, during aging. Mutat Res; 316: 277-85. (Pubitemid 26179270)
8. Kasai H, Iwamoto-Tanaka N, Miyamoto T et al. (2001) Life style and urinary 8-hydroxydeoxyguanosine, a marker of oxidative DNA damage: effects of exercise, working conditions, meat intake, body mass index, and smoking. Jpn J Cancer Res; 92: 9-15. (Pubitemid 32175472)
9. Kawanishi S, Hiraku Y, Oikawa S. (2001) Mechanism of guaninespecific DNA damage by oxidative stress and its role in carcinogenesis and aging. Mutat Res; 488: 65-76. (Pubitemid 32166783)
10. Kim JY, Mukherjee S, Ngo LC et al. (2004) Urinary 8- hydroxy-2- deoxyguanosine as a biomarker of oxidative DNA damage in workers exposed to fine particulates. Environ Health Perspect; 112: 666-71. (Pubitemid 38628394)
11. Kuo HW, Chang SF, Wu KY et al. (2003) Chromium (VI) induced oxidative damage to DNA: increase of urinary 8- hydroxydeoxyguanosine concentrations (8-OHdG) among electroplating workers. Occup Environ Med; 60: 590-4. (Pubitemid 36976405)
12. Lagorio S, Tagesson C, Forastiere Fet al. (1994) Exposure to benzene and urinary concentrations of 8-hydroxydeoxyguanosine, a biological marker of oxidative damage to DNA. Occup Environ Med; 51: 739-43. (Pubitemid 24350449)
13. Lai CH, Liou SH, Lin HC et al. (2005) Exposure to traffic exhausts and oxidative DNA damage. Occup Environ Med; 62: 216-22.
14. Mecocci P, Fano G, Fulle S et al. (1999) Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Radic Biol Med; 26: 303-8. (Pubitemid 29013460)
15. Midorikawa K, Uchida T, Okamoto Y et al. (2004) Metabolic activation of carcinogenic ethylbenzene leads to oxidative DNA damage. Chem Biol Interact; 150: 271-81. (Pubitemid 39550978)
16. Savolainen K, Kekoni J, Riihimaki V et al. (1984) Immediate effects of m-xylene on the human central nervous system. Arch Toxicol Suppl; 7: 412-7. (Pubitemid 14023887)
17. Serron SC, Dwivedi N, Backes WL. (2000) Ethylbenzene induces microsomal oxygen free radical generation: antibody- directed characterization of the responsible cytochrome P450 enzymes. Toxicol Appl Pharmacol; 164: 305-11. (Pubitemid 30314250)
18. Toda C, Uchida T, Midorikawa K et al. (2003) DNA damage by ethylbenzene hydroperoxide formed from carcinogenic ethylbenzene by sunlight irradiation. Biochem Biophys Res Commun; 304: 638-42. (Pubitemid 36513534)