Enhanced sensitivity to afferent stimulation and impact of overactive bladder therapies in the conscious, spontaneously hypertensive rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 338, Issue 1, 2011, Pages 392-399

  Patra, Phani B ^a   Thorneloe, Kevin S ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; ACETIC ACID; CAPSAICIN; DARIFENACIN; GABAPENTIN; OXYBUTYNIN; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER FUNCTION; BLADDER INNERVATION; BLADDER PRESSURE; CONTROLLED STUDY; CYSTOMETRY; DESENSITIZATION; DOSE RESPONSE; DRUG MECHANISM; FEMALE; MICTURITION; NONHUMAN; OVERACTIVE BLADDER; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS; SENSORY NERVE; SPONTANEOUSLY HYPERTENSIVE RAT; SPRAGUE DAWLEY RAT; STRAIN DIFFERENCE; URINE VOLUME;

ACETIC ACID; AFFERENT PATHWAYS; ANIMALS; CONSCIOUSNESS; DINOPROSTONE; FEMALE; MUSCARINIC ANTAGONISTS; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; URINARY BLADDER, OVERACTIVE;

EID: 79959521404     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.180885     Document Type: Article

References (40)

1. Andersson KE, Chapple CR, Cardozo L, Cruz F, Hashim H, Michel MC, Tannenbaum C, and Wein AJ (2009) Pharmacological treatment of overactive bladder: report from the International Consultation on Incontinence. Curr Opin Urol 19:380-394.
2. Angelico P, Velasco C, Guarneri L, Sironi G, Leonardi A, and Testa R (2005) Urodynamic effects of oxybutynin and tolterodine in conscious and anesthetized rats under different cystometrographic conditions. BMC Pharmacol 5:14.
3. Carbone A, Antonio C, Palleschi G, Giovanni P, Conte A, Bova G, Gino B, Iacovelli E, Elisa I, Bettolo CM, et al. (2006) Gabapentin treatment of neurogenic overactive bladder. Clin Neuropharmacol 29:206-214. (Pubitemid 44510457)
4. Chapple C, Steers W, Norton P, Millard R, Kralidis G, Glavind K, and Abrams P (2005) A pooled analysis of three phase III studies to investigate the efficacy, tolerability and safety of darifenacin, a muscarinic M3 selective receptor antagonist, in the treatment of overactive bladder. BJU Int 95:993-1001. (Pubitemid 40655694)
5. Clemow DB, McCarty R, Steers WD, and Tuttle JB (1997) Efferent and afferent neuronal hypertrophy associated with micturition pathways in spontaneously hypertensive rats. Neurourol Urodyn 16:293-303. (Pubitemid 27287517)
6. Clemow DB, Steers WD, McCarty R, and Tuttle JB (1998) Altered regulation of bladder nerve growth factor and neurally mediated hyperactive voiding. Am J Physiol Regul Integr Comp Physiol 275:R1279-R1286.
7. Clouse AK, Riedel E, Hieble JP, and Westfall TD (2007) The effects and selectivity of β-adrenoceptor agonists in rat myometrium and urinary bladder. Eur J Pharmacol 573:184-189. (Pubitemid 47464199)
8. Cruz F and Dinis P (2007) Resiniferatoxin and botulinum toxin type A for treatment of lower urinary tract symptoms. Neurourol Urodyn 26:920-927. (Pubitemid 47548229)
9. Dupont MC, Spitsbergen JM, Kim KB, Tuttle JB, and Steers WD (2001) Histological and neurotrophic changes triggered by varying models of bladder inflammation. J Urol 166:1111-1118. (Pubitemid 32751054)
10. Finney SM, Andersson KE, Gillespie JI, and Stewart LH (2006) Antimuscarinic drugs in detrusor overactivity and the overactive bladder syndrome: motor or sensory actions? BJU Int 98:503-507. (Pubitemid 44185865)
11. Giglio D and Tobin G (2009) Muscarinic receptor subtypes in the lower urinary tract. Pharmacology 83:259-269.
12. 3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog. J Pharmacol Exp Ther 323:202-209.
13. 2+-activated K+ channels. Am J Physiol Cell Physiol 295:C1344-C1353.
14. Igawa Y, Mattiasson A, and Andersson KE (1993) Functional importance of cholinergic and purinergic neurotransmission for micturition contraction in the normal, unanaesthetized rat. Br J Pharmacol 109:473-479. (Pubitemid 23161133)
15. Jin LH, Andersson KE, Kwon YH, Park CS, Yoon SM, and Lee T (2009) Substantial detrusor overactivity in conscious spontaneously hypertensive rats with hyperactive behaviour. Scand J Urol Nephrol 43:3-7.
16. Jin LH, Andersson KE, Kwon YH, Yoon SM, and Lee T (2010) Selection of a control rat for conscious spontaneous hypertensive rats in studies of detrusor overactivity on the basis of measurement of intra-abdominal pressures. Neurourol Urodyn 29:1338-1343.
17. Jugus MJ, Jaworski JP, Patra PB, Jin J, Morrow DM, Laping NJ, Edwards RM, and Thorneloe KS (2009) Dual modulation of urinary bladder activity and urine flow by prostanoid EP3 receptors in the conscious rat. Br J Pharmacol 158:372-381.
18. 3-adrenoceptor agonists on detrusor hyperreflexia in conscious cerebral infarcted rats. J Urol 168:1247-1252.
19. Kim YT, Kwon DD, Kim J, Kim DK, Lee JY, and Chancellor MB (2004) Gabapentin for overactive bladder and nocturia after anticholinergic failure. Int Braz J Urol 30:275-278. (Pubitemid 39255891)
20. Lamb K, Gebhart GF, and Bielefeldt K (2004) Increased nerve growth factor expression triggers bladder overactivity. J Pain 5:150-156. (Pubitemid 38879393)
21. 3-adrenergic receptor agonist disodium 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3- benzodioxole-2,2-dicarboxylate (CL-316243) on bladder micturition reflex in spontaneously hypertensive rats. J Pharmacol Exp Ther 326:178-185.
22. Maggi CA, Giuliani S, Conte B, Furio M, Santicioli P, Meli P, Gragnani L, and Meli A (1988) Prostanoids modulate reflex micturition by acting through capsaicinsensitive afferents. Eur J Pharmacol 145:105-112. (Pubitemid 18028494)
23. McCafferty GP, Coatney RW, Laping NJ, and Thorneloe KS (2009) Urodynamic measurements by radiotelemetry in conscious, freely moving beagle dogs. J Urol 181:1444-1451.
24. Mitsui T, Kakizaki H, Matsuura S, Ameda K, Yoshioka M, and Koyanagi T (2001) Afferent fibers of the hypogastric nerves are involved in the facilitating effects of chemical bladder irritation in rats. J Neurophysiol 86:2276-2284. (Pubitemid 34000590)
25. 3- adrenoceptors in rat retinal blood vessels. Naunyn Schmiedebergs Arch Pharmacol 382:119-126.
26. Ney P, Pandita RK, Newgreen DT, Breidenbach A, Stöhr T, and Andersson KE (2008) Pharmacological characterization of a novel investigational antimuscarinic drug, fesoterodine, in vitro and in vivo. BJU Int 101:1036-1042. (Pubitemid 351422555)
27. Palea S, Toson G, Pietra C, Trist DG, Artibani W, Romano O, and Corsi M (1998) Pharmacological characterization of thromboxane and prostanoid receptors in human isolated urinary bladder. Br J Pharmacol 124:865-872. (Pubitemid 28312819)
28. Patel AK and Chapple CR (2008) Medical management of lower urinary tract symptoms in men: current treatment and future approaches. Nat Clin Pract Urol 5:211-219. (Pubitemid 351517129)
29. Patra PB, Jugus MJ, and Laping NJ (2007) Sex differences in cystometry of normal and hypertensive conscious rat. Curr Urol 1:84-88.
30. Persson K, Pandita RK, Spitsbergen JM, Steers WD, Tuttle JB, and Andersson KE (1998) Spinal and peripheral mechanisms contributing to hyperactive voiding in spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol 275:R1366-R1373.
31. Steers WD, Kolbeck S, Creedon D, and Tuttle JB (1991) Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function. J Clin Invest 88:1709-1715.
32. Steers WD and Tuttle JB (2006) Mechanisms of disease: the role of nerve growth factor in the pathophysiology of bladder disorders. Nat Clin Pract Urol 3:101-110. (Pubitemid 43239267)
33. Su X, Lashinger ES, Leon LA, Hoffman BE, Hieble JP, Gardner SD, Fries HE, Edwards RM, Li J, and Laping NJ (2008) An excitatory role for peripheral EP3 receptors in bladder afferent function. Am J Physiol Renal Physiol 295:F585-F594.
34. 3-adrenoceptor agonist, CL316, 243, and various smooth muscle relaxants. J Pharmacol Exp Ther 293:939-945.
35. 2-induced bladder hyperactivity and on the cardiovascular system in conscious rats. Neurourol Urodyn 21:558-565.
36. Taylor CP (2009) Mechanisms of analgesia by gabapentin and pregabalin-calcium channel α2-δ ligands. Pain 142:13-16.
37. Tong YC, Hung YC, Lin SN, and Cheng JT (1996) The norepinephrine tissue concentration and neuropeptide Y immunoreactivity in genitourinary organs of the spontaneously hypertensive rat. J Auton Nerv Syst 56:215-218.
38. Wang X, Momota Y, Yanase H, Narumiya S, Maruyama T, and Kawatani M (2008) Urothelium EP1 receptor facilitates the micturition reflex in mice. Biomed Res 29:105-111. (Pubitemid 351753470)
39. Yono M, Yoshida M, Yamamoto Y, Imanishi A, Fukagawa A, Latifpour J, and Eto M (2010) Identification of potential therapeutic targets in hypertension-associated bladder dysfunction. BJU Int 105:877-883.
40. Zhang X, Igawa Y, Ishizuka O, Nishizawa O, and Andersson KE (2003) Effects of resiniferatoxin desensitization of capsaicin-sensitive afferents on detrusor overactivity induced by intravesical capsaicin, acetic acid or ATP in conscious rats. Naunyn Schmiedebergs Arch Pharmacol 367:473-479. (Pubitemid 36718298)