Substantial detrusor overactivity in conscious spontaneously hypertensive rats with hyperactive behaviour

Scandinavian Journal of Urology and Nephrology

Volumn 43, Issue 1, 2009, Pages 3-7

  Jin, Long Hu ^a   Andersson, Karl Erik ^b   Kwon, Yong Hyun ^a   Park, Chang Shin ^a   Yoon, Sang Min ^a   Lee, Tack ^a,c  

^a Inha University School of Medicine   (South Korea)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c Inha University Hospital   (South Korea)

Author keywords

Abdomen; Hyperkinesis; Muscle contraction; Overactive; Physiopathology; Spontaneously hypertensive rat; Stress; Urinary bladder; Urodynamics; Wistar ST

Indexed keywords

ABDOMINAL PRESSURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER FILLING; BLADDER PRESSURE; CONTROLLED STUDY; HYPERACTIVITY; MALE; NONHUMAN; OVERACTIVE BLADDER; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR RAT;

ABDOMEN; ANIMALS; COMORBIDITY; DISEASE MODELS, ANIMAL; HYPERKINESIS; MALE; PRESSURE; RATS; RATS, INBRED SHR; RATS, WISTAR; URINARY BLADDER, OVERACTIVE; URODYNAMICS;

EID: 61649085284     PISSN: 00365599     EISSN: 16512065     Source Type: Journal    
DOI: 10.1080/00365590802468750     Document Type: Article

References (17)

1. Persson K, Pandita RK, Spitsbergen JM, Steers WD, Tuttle JB, Andersson KE. Spinal and peripheral mechanisms contributing to hyperactive voiding in spontaneously hypertensive rats. Am J Physiol 1998;275:R1366-73.
2. McMurray G, Casey JH, Naylor AM. Animal models in urological disease and sexual dysfunction. Br J Pharmacol 2006;147(Suppl 2):S62-79.
3. Hendley ED, Ohlsson WG. Two new inbred rat strains derived from SHR: WKHA, hyperactive, and WKHT, hypertensive, rats. Am J Physiol 1991;261:H583-9.
4. Clemow DB, Steers WD, McCarty R, Tuttle JB. Altered regulation of bladder nerve growth factor and neurally mediated hyperactive voiding. Am J Physiol 1998;275:R1279-86.
5. Schafer W, Abrams P, Liao L, Mattiasson A, Pesce F, Spangberg A, et al. Good urodynamic practices: uroflowmetry, filling cystometry, and pressure-flow studies. Neurourol Urodyn 2002;21:261-74.
6. Lee T, Andersson KE, Streng T, Hedlund P. Simultaneous registration of intraabdominal and intravesical pressures during cystometry in conscious rats - effects of bladder outlet obstruction and intravesical PGE2. Neurourol Urodyn 2008;27:88-95.
7. Spitsbergen JM, Clemow DB, McCarty R, Steers WD, Tuttle JB. Neurally mediated hyperactive voiding in spontaneously hypertensive rats. Brain Res 1998;790:151-9.
8. Steers WD, Clemow DB, Persson K, Sherer T, Andersson KE, Tuttl JB. Observations from the spontaneously hypertensive rat. Insight into NGF regulation and noradrenergic hyper-innervation in the lower urinary tract. Adv Exp Med Biol 1999;462:283-92.
9. Rajasekaran M, Wilkes N, Kuntz S, Albo E. Rho-kinase inhibition suppresses bladder hyperactivity in spontaneously hypertensive rats. Neurourol Urodyn 2005;24:295-300.
10. Frazier EP, Schneider T, Michel MC. Effects of gender, age and hypertension on beta-adrenergic receptor function in rat urinary bladder. Naunyn Schmiedebergs Arch Pharmacol 2006;373:300-9.
11. Yono M, Yamamoto Y, Yoshida M, Ueda S, Latifpour J. Effects of doxazosin on blood flow and mRNA expression of nitric oxide synthase in the spontaneously hypertensive rat genitourinary tract. Life Sci 2007;81:218-22.
12. Russell VA. Hypodopaminergic and hypernoradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hyperactivity disorder - the spontaneously hypertensive rat. Behav Brain Res 2002;130:191-6.
13. Oncu B, Oner O, Oner P, Erol N, Aysev A, Canat S. Symptoms defined by parents' and teachers' ratings in attention-deficit hyperactivity disorder: changes with age. Can J Psychiatry 2004;49:487-91.
14. Clemow DB, Spitsbergen JM, McCarty R, Steers WD, Tuttle JB. Altered NGF regulation may link a genetic predisposition for hypertension with hyperactive voiding. J Urol 1999;161:1372-7.
15. de Jong W, Linthorst AC, Versteeg HG. The nigrostriatal dopamine system and the development of hypertension in the spontaneously hypertensive rat. Arch Mal Coeur Vaiss 1995;88:1193-6.
16. Shafik A, El Sibai O. Effect of levator ani muscle contraction on urethrovesical and anorectal pressures and role of the muscle in urination and defecation. Urology 2001;58:193-7.
17. Yang JM, Huang WC. Implications of abdominal straining in women with lower urinary tract symptoms. Urology 2002;60:428-33.