Role of packing defects in the evolution of allostery and induced fit in human UDP-glucose dehydrogenase

Biochemistry

Volumn 50, Issue 25, 2011, Pages 5780-5789

  Kadirvelraj, Renuka ^a   Sennett, Nicholas C ^a   Polizzi, Samuel J ^a   Weitzel, Stephen ^b   Wood, Zachary A ^a  

^a University of Georgia ^*  (United States)

^b UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE STRATEGY; ALLOSTERIC ENZYMES; ALLOSTERIC MECHANISMS; ALLOSTERIC SITE; ALLOSTERIC TRANSITION; ALLOSTERY; BIFUNCTIONAL; D-GLUCOSE; D-XYLOSE; FEEDBACK INHIBITION; INDUCED FIT; MAIN CHAINS; METABOLIC END PRODUCTS; PACKING DEFECT; PROTEIN CORE; SEDIMENTATION VELOCITIES; SIDE-CHAINS; STRUCTURAL MOTIFS; UDP-GLUCOSE DEHYDROGENASE;

BIOCHEMISTRY; ENZYME INHIBITION; GLUCOSE; METABOLISM; XYLOSE;

DEFECTS;

DCTP DEAMINASE; DEAMINASE; HEXAMER; POLYMER; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCOSE DEHYDROGENASE;

ALLOSTERISM; ARTICLE; CONFORMATION; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME DEFECT; ENZYME REGULATION; ENZYME STRUCTURE; FEEDBACK SYSTEM; PRIORITY JOURNAL; SEDIMENTATION RATE;

ALLOSTERIC SITE; AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; EVOLUTION, MOLECULAR; FEEDBACK, PHYSIOLOGICAL; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEOTIDE DEAMINASES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY; URIDINE DIPHOSPHATE GLUCOSE DEHYDROGENASE;

EID: 79959484741     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2005637     Document Type: Article

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